The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions

Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports about how to prepare the working fluid in a re...

Full description

Bibliographic Details
Published in:Frontiers in Molecular Biosciences
Main Authors: Wang, Haibin, Lu, Yingying, Yang, Haisong, Yu, Deng-Guang, Lu, Xuhua
Format: Article in Journal/Newspaper
Language:unknown
Published: Frontiers Media SA 2023
Subjects:
Online Access:http://dx.doi.org/10.3389/fmolb.2023.1184767
https://www.frontiersin.org/articles/10.3389/fmolb.2023.1184767/full
Description
Summary:Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports about how to prepare the working fluid in a reasonable manner. In this study, an investigation was conducted to determine the influences of ultrasonic fluid pretreatment on the quality of resultant ASDs fabricated from the working fluids. SEM results demonstrated that nanofiber-based amorphous solid dispersions from the treated fluids treated amorphous solid dispersions exhibited better quality than the traditional nanofibers from untreated fluids in the following aspects: 1) a straighter linear morphology; 2) a smooth surface; and 3) a more evener diameter distribution. The fabrication mechanism associated with the influences of ultrasonic treatments of working fluids on the resultant nanofibers’ quality is suggested. Although XRD and ATR–FTIR experiments clearly verified that the drug ketoprofen was homogeneously distributed all over the TASDs and the traditional nanofibers in an amorphous state regardless of the ultrasonic treatments, the in vitro dissolution tests clearly demonstrated that the TASDs had a better sustained drug release performance than the traditional nanofibers in terms of the initial release rate and the sustained release time periods.