Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11
The fungal strains Pseudogymnoascus are a kind of psychrophilic pathogenic fungi that are ubiquitously distributed in Antarctica, while the studies of their secondary metabolites are infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11 led to the isolation o...
Published in: | Frontiers in Microbiology |
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Online Access: | http://dx.doi.org/10.3389/fmicb.2021.688202 https://www.frontiersin.org/articles/10.3389/fmicb.2021.688202/full |
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crfrontiers:10.3389/fmicb.2021.688202 2024-06-23T07:46:30+00:00 Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 Shi, Ting Li, Xiang-Qian Zheng, Li Zhang, Ya-Hui Dai, Jia-Jia Shang, Er-Lei Yu, Yan-Yan Zhang, Yi-Ting Hu, Wen-Peng Shi, Da-Yong 2021 http://dx.doi.org/10.3389/fmicb.2021.688202 https://www.frontiersin.org/articles/10.3389/fmicb.2021.688202/full unknown Frontiers Media SA https://creativecommons.org/licenses/by/4.0/ Frontiers in Microbiology volume 12 ISSN 1664-302X journal-article 2021 crfrontiers https://doi.org/10.3389/fmicb.2021.688202 2024-06-11T04:09:33Z The fungal strains Pseudogymnoascus are a kind of psychrophilic pathogenic fungi that are ubiquitously distributed in Antarctica, while the studies of their secondary metabolites are infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11 led to the isolation of six new tremulane sesquiterpenoids pseudotremulanes A–F ( 1 – 6 ), combined with one known analog 11,12-epoxy-12β-hydroxy-1-tremulen-5-one ( 7 ), and five known steroids ( 8 – 12 ). The absolute configurations of the new compounds ( 1 – 6 ) were elucidated by their ECD spectra and ECD calculations. Compounds 1 – 7 were proved to be isomeride structures with the same chemical formula. Compounds 1 / 2 , 3 / 4 , 1 / 4 , and 2 / 3 were identified as four pairs of epimerides at the locations of C-3, C-3, C-9, and C-9, respectively. Compounds 8 and 9 exhibited cytotoxic activities against human breast cancer (MDA-MB-231), colorectal cancer (HCT116), and hepatoma (HepG2) cell lines. Compounds 9 and 10 also showed antibacterial activities against marine fouling bacteria Aeromonas salmonicida . This is the first time to find terpenoids and steroids in the fungal genus Pseudogymnoascus . Article in Journal/Newspaper Antarc* Antarctic Antarctica Frontiers (Publisher) Antarctic The Antarctic Frontiers in Microbiology 12 |
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The fungal strains Pseudogymnoascus are a kind of psychrophilic pathogenic fungi that are ubiquitously distributed in Antarctica, while the studies of their secondary metabolites are infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11 led to the isolation of six new tremulane sesquiterpenoids pseudotremulanes A–F ( 1 – 6 ), combined with one known analog 11,12-epoxy-12β-hydroxy-1-tremulen-5-one ( 7 ), and five known steroids ( 8 – 12 ). The absolute configurations of the new compounds ( 1 – 6 ) were elucidated by their ECD spectra and ECD calculations. Compounds 1 – 7 were proved to be isomeride structures with the same chemical formula. Compounds 1 / 2 , 3 / 4 , 1 / 4 , and 2 / 3 were identified as four pairs of epimerides at the locations of C-3, C-3, C-9, and C-9, respectively. Compounds 8 and 9 exhibited cytotoxic activities against human breast cancer (MDA-MB-231), colorectal cancer (HCT116), and hepatoma (HepG2) cell lines. Compounds 9 and 10 also showed antibacterial activities against marine fouling bacteria Aeromonas salmonicida . This is the first time to find terpenoids and steroids in the fungal genus Pseudogymnoascus . |
format |
Article in Journal/Newspaper |
author |
Shi, Ting Li, Xiang-Qian Zheng, Li Zhang, Ya-Hui Dai, Jia-Jia Shang, Er-Lei Yu, Yan-Yan Zhang, Yi-Ting Hu, Wen-Peng Shi, Da-Yong |
spellingShingle |
Shi, Ting Li, Xiang-Qian Zheng, Li Zhang, Ya-Hui Dai, Jia-Jia Shang, Er-Lei Yu, Yan-Yan Zhang, Yi-Ting Hu, Wen-Peng Shi, Da-Yong Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
author_facet |
Shi, Ting Li, Xiang-Qian Zheng, Li Zhang, Ya-Hui Dai, Jia-Jia Shang, Er-Lei Yu, Yan-Yan Zhang, Yi-Ting Hu, Wen-Peng Shi, Da-Yong |
author_sort |
Shi, Ting |
title |
Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_short |
Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_full |
Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_fullStr |
Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_full_unstemmed |
Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11 |
title_sort |
sesquiterpenoids from the antarctic fungus pseudogymnoascus sp. hsx2#-11 |
publisher |
Frontiers Media SA |
publishDate |
2021 |
url |
http://dx.doi.org/10.3389/fmicb.2021.688202 https://www.frontiersin.org/articles/10.3389/fmicb.2021.688202/full |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
Frontiers in Microbiology volume 12 ISSN 1664-302X |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3389/fmicb.2021.688202 |
container_title |
Frontiers in Microbiology |
container_volume |
12 |
_version_ |
1802646364222390272 |