Immunological Aspects of Isolation and Confinement
Beyond all doubts, the exploration of outer space is a strategically important and priority sector of the national economy, scientific and technological development of every and particular country, and of all human civilization in general. A number of stress factors, including a prolonged confinemen...
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crfrontiers:10.3389/fimmu.2021.697435 2024-06-23T07:47:42+00:00 Immunological Aspects of Isolation and Confinement Ponomarev, Sergey Kalinin, Sergey Sadova, Anastasiya Rykova, Marina Orlova, Kseniya Crucian, Brian Ministry of Science and Higher Education of the Russian Federation 2021 http://dx.doi.org/10.3389/fimmu.2021.697435 https://www.frontiersin.org/articles/10.3389/fimmu.2021.697435/full unknown Frontiers Media SA https://creativecommons.org/licenses/by/4.0/ Frontiers in Immunology volume 12 ISSN 1664-3224 journal-article 2021 crfrontiers https://doi.org/10.3389/fimmu.2021.697435 2024-06-11T04:08:11Z Beyond all doubts, the exploration of outer space is a strategically important and priority sector of the national economy, scientific and technological development of every and particular country, and of all human civilization in general. A number of stress factors, including a prolonged confinement in a limited hermetically sealed space, influence the human body in space on board the spaceship and during the orbital flight. All these factors predominantly negatively affect various functional systems of the organism, in particular, the astronaut’s immunity. These ground-based experiments allow to elucidate the effect of confinement in a limited space on both the activation of the immunity and the changes of the immune status in dynamics. Also, due to simulation of one or another emergency situation, such an approach allows the estimation of the influence of an additional psychological stress on the immunity, particularly, in the context of the reserve capacity of the immune system. A sealed chamber seems a convenient site for working out the additional techniques for crew members selection, as well as the countermeasures for negative changes in the astronauts’ immune status. In this review we attempted to collect information describing changes in human immunity during isolation experiments with different conditions including short- and long-term experiments in hermetically closed chambers with artificial environment and during Antarctic winter-over. Article in Journal/Newspaper Antarc* Antarctic Frontiers (Publisher) Antarctic Frontiers in Immunology 12 |
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Beyond all doubts, the exploration of outer space is a strategically important and priority sector of the national economy, scientific and technological development of every and particular country, and of all human civilization in general. A number of stress factors, including a prolonged confinement in a limited hermetically sealed space, influence the human body in space on board the spaceship and during the orbital flight. All these factors predominantly negatively affect various functional systems of the organism, in particular, the astronaut’s immunity. These ground-based experiments allow to elucidate the effect of confinement in a limited space on both the activation of the immunity and the changes of the immune status in dynamics. Also, due to simulation of one or another emergency situation, such an approach allows the estimation of the influence of an additional psychological stress on the immunity, particularly, in the context of the reserve capacity of the immune system. A sealed chamber seems a convenient site for working out the additional techniques for crew members selection, as well as the countermeasures for negative changes in the astronauts’ immune status. In this review we attempted to collect information describing changes in human immunity during isolation experiments with different conditions including short- and long-term experiments in hermetically closed chambers with artificial environment and during Antarctic winter-over. |
author2 |
Ministry of Science and Higher Education of the Russian Federation |
format |
Article in Journal/Newspaper |
author |
Ponomarev, Sergey Kalinin, Sergey Sadova, Anastasiya Rykova, Marina Orlova, Kseniya Crucian, Brian |
spellingShingle |
Ponomarev, Sergey Kalinin, Sergey Sadova, Anastasiya Rykova, Marina Orlova, Kseniya Crucian, Brian Immunological Aspects of Isolation and Confinement |
author_facet |
Ponomarev, Sergey Kalinin, Sergey Sadova, Anastasiya Rykova, Marina Orlova, Kseniya Crucian, Brian |
author_sort |
Ponomarev, Sergey |
title |
Immunological Aspects of Isolation and Confinement |
title_short |
Immunological Aspects of Isolation and Confinement |
title_full |
Immunological Aspects of Isolation and Confinement |
title_fullStr |
Immunological Aspects of Isolation and Confinement |
title_full_unstemmed |
Immunological Aspects of Isolation and Confinement |
title_sort |
immunological aspects of isolation and confinement |
publisher |
Frontiers Media SA |
publishDate |
2021 |
url |
http://dx.doi.org/10.3389/fimmu.2021.697435 https://www.frontiersin.org/articles/10.3389/fimmu.2021.697435/full |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Frontiers in Immunology volume 12 ISSN 1664-3224 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3389/fimmu.2021.697435 |
container_title |
Frontiers in Immunology |
container_volume |
12 |
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1802651863782260736 |