A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort
Psoriasis is an immune-mediated inflammatory skin disease typically characterized by erythematous and scaly plaques. It affects 3% of the Newfoundland population while only affecting 1.7% of the general Canadian population. Recent genome-wide association studies (GWAS) in psoriasis have identified m...
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Online Access: | http://dx.doi.org/10.3389/fgene.2023.1141010 https://www.frontiersin.org/articles/10.3389/fgene.2023.1141010/full |
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crfrontiers:10.3389/fgene.2023.1141010 2024-05-19T07:44:14+00:00 A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort Bui, Audrey Kumar, Sugandh Liu, Jared Orcales, Faye Gulliver, Susanne Tsoi, Lam C. Gulliver, Wayne Liao, Wilson 2023 http://dx.doi.org/10.3389/fgene.2023.1141010 https://www.frontiersin.org/articles/10.3389/fgene.2023.1141010/full unknown Frontiers Media SA https://creativecommons.org/licenses/by/4.0/ Frontiers in Genetics volume 14 ISSN 1664-8021 journal-article 2023 crfrontiers https://doi.org/10.3389/fgene.2023.1141010 2024-04-24T07:11:45Z Psoriasis is an immune-mediated inflammatory skin disease typically characterized by erythematous and scaly plaques. It affects 3% of the Newfoundland population while only affecting 1.7% of the general Canadian population. Recent genome-wide association studies (GWAS) in psoriasis have identified more than 63 genetic susceptibility loci that individually have modest effects. Prior studies have shown that a genetic risk score (GRS) combining multiple loci can improve psoriasis disease prediction. However, these prior GRS studies have not fully explored the association of GRS with patient clinical characteristics. In this study, we calculated three types of GRS: one using all known GWAS SNPs (GRS-ALL), one using a subset of SNPs from the HLA region (GRS-HLA), and the last using non-HLA SNPs (GRS-noHLA). We examined the relationship between these GRS and a number of psoriasis features within a well characterized Newfoundland psoriasis cohort. We found that both GRS-ALL and GRS-HLA were significantly associated with early age of psoriasis onset, psoriasis severity, first presentation of psoriasis at the elbow or knee, and the total number of body locations affected, while only GRS-ALL was associated with a positive family history of psoriasis. GRS-noHLA was uniquely associated with genital psoriasis. These findings clarify the relationship of the HLA and non-HLA components of GRS with important clinical features of psoriasis. Article in Journal/Newspaper Newfoundland Frontiers (Publisher) Frontiers in Genetics 14 |
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Psoriasis is an immune-mediated inflammatory skin disease typically characterized by erythematous and scaly plaques. It affects 3% of the Newfoundland population while only affecting 1.7% of the general Canadian population. Recent genome-wide association studies (GWAS) in psoriasis have identified more than 63 genetic susceptibility loci that individually have modest effects. Prior studies have shown that a genetic risk score (GRS) combining multiple loci can improve psoriasis disease prediction. However, these prior GRS studies have not fully explored the association of GRS with patient clinical characteristics. In this study, we calculated three types of GRS: one using all known GWAS SNPs (GRS-ALL), one using a subset of SNPs from the HLA region (GRS-HLA), and the last using non-HLA SNPs (GRS-noHLA). We examined the relationship between these GRS and a number of psoriasis features within a well characterized Newfoundland psoriasis cohort. We found that both GRS-ALL and GRS-HLA were significantly associated with early age of psoriasis onset, psoriasis severity, first presentation of psoriasis at the elbow or knee, and the total number of body locations affected, while only GRS-ALL was associated with a positive family history of psoriasis. GRS-noHLA was uniquely associated with genital psoriasis. These findings clarify the relationship of the HLA and non-HLA components of GRS with important clinical features of psoriasis. |
format |
Article in Journal/Newspaper |
author |
Bui, Audrey Kumar, Sugandh Liu, Jared Orcales, Faye Gulliver, Susanne Tsoi, Lam C. Gulliver, Wayne Liao, Wilson |
spellingShingle |
Bui, Audrey Kumar, Sugandh Liu, Jared Orcales, Faye Gulliver, Susanne Tsoi, Lam C. Gulliver, Wayne Liao, Wilson A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort |
author_facet |
Bui, Audrey Kumar, Sugandh Liu, Jared Orcales, Faye Gulliver, Susanne Tsoi, Lam C. Gulliver, Wayne Liao, Wilson |
author_sort |
Bui, Audrey |
title |
A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort |
title_short |
A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort |
title_full |
A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort |
title_fullStr |
A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort |
title_full_unstemmed |
A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort |
title_sort |
partitioned 88-loci psoriasis genetic risk score reveals hla and non-hla contributions to clinical phenotypes in a newfoundland psoriasis cohort |
publisher |
Frontiers Media SA |
publishDate |
2023 |
url |
http://dx.doi.org/10.3389/fgene.2023.1141010 https://www.frontiersin.org/articles/10.3389/fgene.2023.1141010/full |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Frontiers in Genetics volume 14 ISSN 1664-8021 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3389/fgene.2023.1141010 |
container_title |
Frontiers in Genetics |
container_volume |
14 |
_version_ |
1799483991722557440 |