Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However...
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crfrontiers:10.3389/fchem.2023.1223967 2024-02-11T10:03:22+01:00 Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis Jameson, J. Brian Wang, Jiaming Bailey, Patrick C. Oldham, Michael J. Smith, Cameron R. Jeong, Lena N. Cook, David K. Bates, Austin L. Ullah, Sifat Pennington, Alexander S. C. Gillman, I. Gene 2023 http://dx.doi.org/10.3389/fchem.2023.1223967 https://www.frontiersin.org/articles/10.3389/fchem.2023.1223967/full unknown Frontiers Media SA https://creativecommons.org/licenses/by/4.0/ Frontiers in Chemistry volume 11 ISSN 2296-2646 General Chemistry journal-article 2023 crfrontiers https://doi.org/10.3389/fchem.2023.1223967 2024-01-26T10:00:00Z Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested. Article in Journal/Newspaper DML Frontiers (Publisher) Frontiers in Chemistry 11 |
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General Chemistry |
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General Chemistry Jameson, J. Brian Wang, Jiaming Bailey, Patrick C. Oldham, Michael J. Smith, Cameron R. Jeong, Lena N. Cook, David K. Bates, Austin L. Ullah, Sifat Pennington, Alexander S. C. Gillman, I. Gene Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
topic_facet |
General Chemistry |
description |
Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested. |
format |
Article in Journal/Newspaper |
author |
Jameson, J. Brian Wang, Jiaming Bailey, Patrick C. Oldham, Michael J. Smith, Cameron R. Jeong, Lena N. Cook, David K. Bates, Austin L. Ullah, Sifat Pennington, Alexander S. C. Gillman, I. Gene |
author_facet |
Jameson, J. Brian Wang, Jiaming Bailey, Patrick C. Oldham, Michael J. Smith, Cameron R. Jeong, Lena N. Cook, David K. Bates, Austin L. Ullah, Sifat Pennington, Alexander S. C. Gillman, I. Gene |
author_sort |
Jameson, J. Brian |
title |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_short |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_full |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_fullStr |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_full_unstemmed |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_sort |
determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
publisher |
Frontiers Media SA |
publishDate |
2023 |
url |
http://dx.doi.org/10.3389/fchem.2023.1223967 https://www.frontiersin.org/articles/10.3389/fchem.2023.1223967/full |
genre |
DML |
genre_facet |
DML |
op_source |
Frontiers in Chemistry volume 11 ISSN 2296-2646 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3389/fchem.2023.1223967 |
container_title |
Frontiers in Chemistry |
container_volume |
11 |
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1790599592335638528 |