Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin

Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited reports of their isolation from atmospheric precip...

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Published in:Frontiers in Chemistry
Main Authors: Sarmiento-Vizcaíno, Aida, Martín, Jesús, Ortiz-López, Francisco Javier, Reyes, Fernando, García, Luis A., Blanco, Gloria
Format: Article in Journal/Newspaper
Language:unknown
Published: Frontiers Media SA 2022
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Online Access:http://dx.doi.org/10.3389/fchem.2022.948795
https://www.frontiersin.org/articles/10.3389/fchem.2022.948795/full
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spelling crfrontiers:10.3389/fchem.2022.948795 2024-03-31T07:50:57+00:00 Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin Sarmiento-Vizcaíno, Aida Martín, Jesús Ortiz-López, Francisco Javier Reyes, Fernando García, Luis A. Blanco, Gloria 2022 http://dx.doi.org/10.3389/fchem.2022.948795 https://www.frontiersin.org/articles/10.3389/fchem.2022.948795/full unknown Frontiers Media SA https://creativecommons.org/licenses/by/4.0/ Frontiers in Chemistry volume 10 ISSN 2296-2646 General Chemistry journal-article 2022 crfrontiers https://doi.org/10.3389/fchem.2022.948795 2024-03-05T00:16:45Z Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited reports of their isolation from atmospheric precipitations. Clouds are considered as atmospheric oases for microorganisms and there is a recent paradigm shift whereby atmospheric-derived Actinobacteria emerge as an alternative source for drug discovery. In this context, we studied a total of 18 bioactive Actinobacteria strains, isolated by sampling nine precipitation events with prevailing Northern winds in the Cantabrian Sea coast, Northern Spain. Backward trajectories meteorological analyses indicate that air masses were originated mostly in the Arctic Ocean, and their trajectory to downwind areas involved the Atlantic Ocean and also terrestrial sources from continental Europe, and in some events from Canada, Greenland, Mauritania and Canary Islands. Taxonomic identification of the isolates, by 16S rRNA gene sequencing and phylogenetic analyses, revealed that they are members of three Actinobacteria genera. Fifteen of the isolates are Streptomyces species, thus increasing the number of bioactive species of this genus in the atmosphere to a 6.8% of the total currently validated species. In addition, two of the strains belong to the genus Micromonospora and one to genus Nocardiopsis . These findings reinforce a previous atmospheric dispersal model, extended herein to the genus Micromonospora . Production of bioactive secondary metabolites was screened in ethyl acetate extracts of the strains by LC-UV-MS and a total of 94 secondary metabolites were detected after LC/MS dereplication. Comparative analyses with natural products databases allowed the identification of 69 structurally diverse natural products with contrasted biological activities, mostly as antibiotics and antitumor agents, but also anti-inflammatory, antiviral, antiparasitic, immunosuppressant and ... Article in Journal/Newspaper Arctic Arctic Ocean Greenland Frontiers (Publisher) Arctic Arctic Ocean Canada Greenland Frontiers in Chemistry 10
institution Open Polar
collection Frontiers (Publisher)
op_collection_id crfrontiers
language unknown
topic General Chemistry
spellingShingle General Chemistry
Sarmiento-Vizcaíno, Aida
Martín, Jesús
Ortiz-López, Francisco Javier
Reyes, Fernando
García, Luis A.
Blanco, Gloria
Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin
topic_facet General Chemistry
description Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited reports of their isolation from atmospheric precipitations. Clouds are considered as atmospheric oases for microorganisms and there is a recent paradigm shift whereby atmospheric-derived Actinobacteria emerge as an alternative source for drug discovery. In this context, we studied a total of 18 bioactive Actinobacteria strains, isolated by sampling nine precipitation events with prevailing Northern winds in the Cantabrian Sea coast, Northern Spain. Backward trajectories meteorological analyses indicate that air masses were originated mostly in the Arctic Ocean, and their trajectory to downwind areas involved the Atlantic Ocean and also terrestrial sources from continental Europe, and in some events from Canada, Greenland, Mauritania and Canary Islands. Taxonomic identification of the isolates, by 16S rRNA gene sequencing and phylogenetic analyses, revealed that they are members of three Actinobacteria genera. Fifteen of the isolates are Streptomyces species, thus increasing the number of bioactive species of this genus in the atmosphere to a 6.8% of the total currently validated species. In addition, two of the strains belong to the genus Micromonospora and one to genus Nocardiopsis . These findings reinforce a previous atmospheric dispersal model, extended herein to the genus Micromonospora . Production of bioactive secondary metabolites was screened in ethyl acetate extracts of the strains by LC-UV-MS and a total of 94 secondary metabolites were detected after LC/MS dereplication. Comparative analyses with natural products databases allowed the identification of 69 structurally diverse natural products with contrasted biological activities, mostly as antibiotics and antitumor agents, but also anti-inflammatory, antiviral, antiparasitic, immunosuppressant and ...
format Article in Journal/Newspaper
author Sarmiento-Vizcaíno, Aida
Martín, Jesús
Ortiz-López, Francisco Javier
Reyes, Fernando
García, Luis A.
Blanco, Gloria
author_facet Sarmiento-Vizcaíno, Aida
Martín, Jesús
Ortiz-López, Francisco Javier
Reyes, Fernando
García, Luis A.
Blanco, Gloria
author_sort Sarmiento-Vizcaíno, Aida
title Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin
title_short Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin
title_full Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin
title_fullStr Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin
title_full_unstemmed Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin
title_sort natural products, including a new caboxamycin, from streptomyces and other actinobacteria isolated in spain from storm clouds transported by northern winds of arctic origin
publisher Frontiers Media SA
publishDate 2022
url http://dx.doi.org/10.3389/fchem.2022.948795
https://www.frontiersin.org/articles/10.3389/fchem.2022.948795/full
geographic Arctic
Arctic Ocean
Canada
Greenland
geographic_facet Arctic
Arctic Ocean
Canada
Greenland
genre Arctic
Arctic Ocean
Greenland
genre_facet Arctic
Arctic Ocean
Greenland
op_source Frontiers in Chemistry
volume 10
ISSN 2296-2646
op_rights https://creativecommons.org/licenses/by/4.0/
op_doi https://doi.org/10.3389/fchem.2022.948795
container_title Frontiers in Chemistry
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