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crelifesciences:10.7554/elife.37267.018
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openpolar
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crelifesciences:10.7554/elife.37267.018 2023-07-23T04:19:01+02:00 Figure 7. E47 modulates in opposite ways the neurogenic abilities of ASCL1 and NEUROG1/NEUROG2 during corticogenesis. (A) Scheme of the embryonic chick telencephalon at early stages of neurogenesis. (B–D) Coronal telencephalic sections showing PAX6 immunoreactivity and the cell nuclei (DAPI) at low magnification at E4 (B), cortical progenitors and differentiating neurons (SOX2 +and HuC/D+, (C), apical progenitors (PAX6+;TBR2-, (D) and mitotic basal progenitors (TBR2+;pH3+, arrow in D’’) at E3 (C, D), E4 (C’, D’) and E5 (C’’, D’’). (E–H) Detection of cTcf3/cE2a (E), cNeurog1 (F), cNeurog2 (G) and cAscl1 (H) transcripts by in situ hybridization at E4. (I) In ovo electroporation of the chick telencephalon. (J–Q) Coronal telencephalic sections of electroporated cells (GFP+) that differentiated into neurons (HuC/D+) 48 hpe with a control (J), ASCL1 (K), NEUROG1 (L) or NEUROG2 (M) on their own or together with E47 (N–Q). (R) Box-and-whisker plots obtained from n = 5–9 embryos; one-way ANOVA + Tukey’s test; *p<0.05. Scale bars, 50 µM. CCx, cerebral cortex; dT/vT, dorsal and ventral telencephalon; dML, dorso-medial-lateral; VZ, ventricular zone. 2018-09-06T10:00:56Z http://dx.doi.org/10.7554/elife.37267.018 unknown eLife Sciences Publications, Ltd component 2018 crelifesciences https://doi.org/10.7554/elife.37267.018 2023-07-05T08:36:39Z Other/Unknown Material DML eLife (E-Journal - via Crossref)
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Open Polar
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eLife (E-Journal - via Crossref)
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crelifesciences
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unknown
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Other/Unknown Material
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| title |
Figure 7. E47 modulates in opposite ways the neurogenic abilities of ASCL1 and NEUROG1/NEUROG2 during corticogenesis.
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| spellingShingle |
Figure 7. E47 modulates in opposite ways the neurogenic abilities of ASCL1 and NEUROG1/NEUROG2 during corticogenesis.
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| title_short |
Figure 7. E47 modulates in opposite ways the neurogenic abilities of ASCL1 and NEUROG1/NEUROG2 during corticogenesis.
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| title_full |
Figure 7. E47 modulates in opposite ways the neurogenic abilities of ASCL1 and NEUROG1/NEUROG2 during corticogenesis.
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| title_fullStr |
Figure 7. E47 modulates in opposite ways the neurogenic abilities of ASCL1 and NEUROG1/NEUROG2 during corticogenesis.
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| title_full_unstemmed |
Figure 7. E47 modulates in opposite ways the neurogenic abilities of ASCL1 and NEUROG1/NEUROG2 during corticogenesis.
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| title_sort |
figure 7. e47 modulates in opposite ways the neurogenic abilities of ascl1 and neurog1/neurog2 during corticogenesis.
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| publisher |
eLife Sciences Publications, Ltd
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| publishDate |
2018
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| url |
http://dx.doi.org/10.7554/elife.37267.018
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DML
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DML
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| op_doi |
https://doi.org/10.7554/elife.37267.018
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| _version_ |
1772181783639490560
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