Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata
The development of new antibacterial compounds is an urgent issue to meet the evolution of resistivity of pathogenic bacteria against the available drugs. The objective of this study was to investigate the antibacterial compounds from the Antarctic lichen species Ramalina terebrata. A total of fi ve...
Published in: | Zeitschrift für Naturforschung C |
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Language: | English |
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Walter de Gruyter GmbH
2010
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Online Access: | http://dx.doi.org/10.1515/znc-2010-1-206 http://www.degruyter.com/view/j/znc.2010.65.issue-1-2/znc-2010-1-206/znc-2010-1-206.xml https://www.degruyter.com/document/doi/10.1515/znc-2010-1-206/xml https://www.degruyter.com/document/doi/10.1515/znc-2010-1-206/pdf |
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crdegruyter:10.1515/znc-2010-1-206 2024-09-15T17:45:43+00:00 Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata Paudel, Babita Bhattarai, Hari Datta Lee, Hong Kum Oh, Hyuncheol Shin, Hyun Woung Yim, Joung Han 2010 http://dx.doi.org/10.1515/znc-2010-1-206 http://www.degruyter.com/view/j/znc.2010.65.issue-1-2/znc-2010-1-206/znc-2010-1-206.xml https://www.degruyter.com/document/doi/10.1515/znc-2010-1-206/xml https://www.degruyter.com/document/doi/10.1515/znc-2010-1-206/pdf en eng Walter de Gruyter GmbH http://creativecommons.org/licenses/by-nc-nd/3.0/ Zeitschrift für Naturforschung C volume 65, issue 1-2, page 34-38 ISSN 1865-7125 0939-5075 journal-article 2010 crdegruyter https://doi.org/10.1515/znc-2010-1-206 2024-07-29T04:11:23Z The development of new antibacterial compounds is an urgent issue to meet the evolution of resistivity of pathogenic bacteria against the available drugs. The objective of this study was to investigate the antibacterial compounds from the Antarctic lichen species Ramalina terebrata. A total of fi ve compounds, usnic acid, usimine A, usimine B, usimine C, and ramalin, were isolated by bioactivity guided-fractionation of the methanol extract of R. terebrata after several chromatographic procedures. The qualitative antibacterial activities of the crude extract and isolated compounds were determined by the disk diffusion method while the minimum inhibitory concentration (MIC) determination assay gave the quantitative strength of the test samples. All the test samples showed antibacterial activity against Bacillus subtilis. The crude extract and usnic acid showed antibacterial activity against Staphylococcus aureus. The MIC values of the isolated compounds against B. subtilis were in the range of 1 to 26 μg/mL. These observed experimental data showed the strong antibacterial potential of these compounds against B. subtilis. Article in Journal/Newspaper Antarc* Antarctic De Gruyter Zeitschrift für Naturforschung C 65 1-2 34 38 |
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language |
English |
description |
The development of new antibacterial compounds is an urgent issue to meet the evolution of resistivity of pathogenic bacteria against the available drugs. The objective of this study was to investigate the antibacterial compounds from the Antarctic lichen species Ramalina terebrata. A total of fi ve compounds, usnic acid, usimine A, usimine B, usimine C, and ramalin, were isolated by bioactivity guided-fractionation of the methanol extract of R. terebrata after several chromatographic procedures. The qualitative antibacterial activities of the crude extract and isolated compounds were determined by the disk diffusion method while the minimum inhibitory concentration (MIC) determination assay gave the quantitative strength of the test samples. All the test samples showed antibacterial activity against Bacillus subtilis. The crude extract and usnic acid showed antibacterial activity against Staphylococcus aureus. The MIC values of the isolated compounds against B. subtilis were in the range of 1 to 26 μg/mL. These observed experimental data showed the strong antibacterial potential of these compounds against B. subtilis. |
format |
Article in Journal/Newspaper |
author |
Paudel, Babita Bhattarai, Hari Datta Lee, Hong Kum Oh, Hyuncheol Shin, Hyun Woung Yim, Joung Han |
spellingShingle |
Paudel, Babita Bhattarai, Hari Datta Lee, Hong Kum Oh, Hyuncheol Shin, Hyun Woung Yim, Joung Han Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata |
author_facet |
Paudel, Babita Bhattarai, Hari Datta Lee, Hong Kum Oh, Hyuncheol Shin, Hyun Woung Yim, Joung Han |
author_sort |
Paudel, Babita |
title |
Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata |
title_short |
Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata |
title_full |
Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata |
title_fullStr |
Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata |
title_full_unstemmed |
Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata |
title_sort |
antibacterial activities of ramalin, usnic acid and its three derivatives isolated from the antarctic lichen ramalina terebrata |
publisher |
Walter de Gruyter GmbH |
publishDate |
2010 |
url |
http://dx.doi.org/10.1515/znc-2010-1-206 http://www.degruyter.com/view/j/znc.2010.65.issue-1-2/znc-2010-1-206/znc-2010-1-206.xml https://www.degruyter.com/document/doi/10.1515/znc-2010-1-206/xml https://www.degruyter.com/document/doi/10.1515/znc-2010-1-206/pdf |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Zeitschrift für Naturforschung C volume 65, issue 1-2, page 34-38 ISSN 1865-7125 0939-5075 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/3.0/ |
op_doi |
https://doi.org/10.1515/znc-2010-1-206 |
container_title |
Zeitschrift für Naturforschung C |
container_volume |
65 |
container_issue |
1-2 |
container_start_page |
34 |
op_container_end_page |
38 |
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1810493622690250752 |