Antarones A and B, Two Polyketides from an Endophytic Penicillium antarcticum

• Published in: Zeitschrift für Naturforschung B
• Main Authors: Shiono, Yoshihito, Seino, Yumi, Koseki, Takuya, Murayama, Tetsuya, Kimura, Ken-ichi
• Format: Article in Journal/Newspaper
• Language: English
• Published: Walter de Gruyter GmbH 2008
• Subjects: General Chemistry; Antarc*
• Online Access: http://dx.doi.org/10.1515/znb-2008-0716; https://www.degruyter.com/view/journals/znb/63/7/article-p909.xml; https://www.degruyter.com/document/doi/10.1515/znb-2008-0716/xml; https://www.degruyter.com/document/doi/10.1515/znb-2008-0716/pdf

Two new polyketides, antarones A and B, were isolated from the endophytic fungus Penicillium antarcticum. Their structures were determined by spectroscopic methods. Their general toxicity and cytotoxicity were evaluated, respectively, by brine shrimp lethality and cytotoxicity assay with human cancer cell lines. Neither antarones A nor B exhibited activity at the concentration of 100 μM.