Antarones A and B, Two Polyketides from an Endophytic Penicillium antarcticum

Two new polyketides, antarones A and B, were isolated from the endophytic fungus Penicillium antarcticum. Their structures were determined by spectroscopic methods. Their general toxicity and cytotoxicity were evaluated, respectively, by brine shrimp lethality and cytotoxicity assay with human cance...

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Bibliographic Details
Published in:Zeitschrift für Naturforschung B
Main Authors: Shiono, Yoshihito, Seino, Yumi, Koseki, Takuya, Murayama, Tetsuya, Kimura, Ken-ichi
Format: Article in Journal/Newspaper
Language:English
Published: Walter de Gruyter GmbH 2008
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Online Access:http://dx.doi.org/10.1515/znb-2008-0716
https://www.degruyter.com/view/journals/znb/63/7/article-p909.xml
https://www.degruyter.com/document/doi/10.1515/znb-2008-0716/xml
https://www.degruyter.com/document/doi/10.1515/znb-2008-0716/pdf
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Summary:Two new polyketides, antarones A and B, were isolated from the endophytic fungus Penicillium antarcticum. Their structures were determined by spectroscopic methods. Their general toxicity and cytotoxicity were evaluated, respectively, by brine shrimp lethality and cytotoxicity assay with human cancer cell lines. Neither antarones A nor B exhibited activity at the concentration of 100 μM.