A Green Process for Synthesis of Geraniol Esters by Immobilized Lipase from Candida Antarctica B Fraction in Non-Aqueous Reaction Media: Optimization and Kinetic Modeling
Abstract Enzymatic synthesis of molecules such as flavors, perfumes and fragrances has a great commercial advantage of being marketed as “natural” and also it offers exquisite selectivity of enzymes that can be superior over chemical catalysis. The current work focuses on the enzymatic synthesis of...
Published in: | International Journal of Chemical Reactor Engineering |
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Walter de Gruyter GmbH
2018
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crdegruyter:10.1515/ijcre-2017-0179 2024-04-07T07:47:38+00:00 A Green Process for Synthesis of Geraniol Esters by Immobilized Lipase from Candida Antarctica B Fraction in Non-Aqueous Reaction Media: Optimization and Kinetic Modeling Yadav, Ganapati D. Kamble, Manoj P. 2018 http://dx.doi.org/10.1515/ijcre-2017-0179 http://www.degruyter.com/view/j/ijcre.2018.16.issue-7/ijcre-2017-0179/ijcre-2017-0179.xml https://www.degruyter.com/document/doi/10.1515/ijcre-2017-0179/pdf unknown Walter de Gruyter GmbH International Journal of Chemical Reactor Engineering volume 16, issue 7 ISSN 1542-6580 General Chemical Engineering journal-article 2018 crdegruyter https://doi.org/10.1515/ijcre-2017-0179 2024-03-08T00:40:43Z Abstract Enzymatic synthesis of molecules such as flavors, perfumes and fragrances has a great commercial advantage of being marketed as “natural” and also it offers exquisite selectivity of enzymes that can be superior over chemical catalysis. The current work focuses on the enzymatic synthesis of geranyl acetate as model compound, including optimization of reaction conditions such as nature of catalyst, reaction media, speed of agitation, mole ratio and temperature. A variety of esters were also synthesized. Geraniol was esterified with various acids, aromatic esters and vinyl esters in 1:4 molar ratio. Among all vinyl ester was the best giving in good yield (77–100 %) as compared to aromatic esters (5–82 %) and acids (7–31 %). Novozym 435 was found to be most active catalyst with ~96 % conversion and 100 % selectivity in 60 min at 55 °C in n-heptane as solvent for geranyl acetate. The maximum reaction rate was estimated (V max = 0.2712 mol L −1 min -1 ) by using the double reciprocal plot. It is a ternary complex (ordered bi-bi) mechanism with inhibition by geraniol. Article in Journal/Newspaper Antarc* Antarctica De Gruyter International Journal of Chemical Reactor Engineering 16 7 |
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General Chemical Engineering |
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General Chemical Engineering Yadav, Ganapati D. Kamble, Manoj P. A Green Process for Synthesis of Geraniol Esters by Immobilized Lipase from Candida Antarctica B Fraction in Non-Aqueous Reaction Media: Optimization and Kinetic Modeling |
topic_facet |
General Chemical Engineering |
description |
Abstract Enzymatic synthesis of molecules such as flavors, perfumes and fragrances has a great commercial advantage of being marketed as “natural” and also it offers exquisite selectivity of enzymes that can be superior over chemical catalysis. The current work focuses on the enzymatic synthesis of geranyl acetate as model compound, including optimization of reaction conditions such as nature of catalyst, reaction media, speed of agitation, mole ratio and temperature. A variety of esters were also synthesized. Geraniol was esterified with various acids, aromatic esters and vinyl esters in 1:4 molar ratio. Among all vinyl ester was the best giving in good yield (77–100 %) as compared to aromatic esters (5–82 %) and acids (7–31 %). Novozym 435 was found to be most active catalyst with ~96 % conversion and 100 % selectivity in 60 min at 55 °C in n-heptane as solvent for geranyl acetate. The maximum reaction rate was estimated (V max = 0.2712 mol L −1 min -1 ) by using the double reciprocal plot. It is a ternary complex (ordered bi-bi) mechanism with inhibition by geraniol. |
format |
Article in Journal/Newspaper |
author |
Yadav, Ganapati D. Kamble, Manoj P. |
author_facet |
Yadav, Ganapati D. Kamble, Manoj P. |
author_sort |
Yadav, Ganapati D. |
title |
A Green Process for Synthesis of Geraniol Esters by Immobilized Lipase from Candida Antarctica B Fraction in Non-Aqueous Reaction Media: Optimization and Kinetic Modeling |
title_short |
A Green Process for Synthesis of Geraniol Esters by Immobilized Lipase from Candida Antarctica B Fraction in Non-Aqueous Reaction Media: Optimization and Kinetic Modeling |
title_full |
A Green Process for Synthesis of Geraniol Esters by Immobilized Lipase from Candida Antarctica B Fraction in Non-Aqueous Reaction Media: Optimization and Kinetic Modeling |
title_fullStr |
A Green Process for Synthesis of Geraniol Esters by Immobilized Lipase from Candida Antarctica B Fraction in Non-Aqueous Reaction Media: Optimization and Kinetic Modeling |
title_full_unstemmed |
A Green Process for Synthesis of Geraniol Esters by Immobilized Lipase from Candida Antarctica B Fraction in Non-Aqueous Reaction Media: Optimization and Kinetic Modeling |
title_sort |
green process for synthesis of geraniol esters by immobilized lipase from candida antarctica b fraction in non-aqueous reaction media: optimization and kinetic modeling |
publisher |
Walter de Gruyter GmbH |
publishDate |
2018 |
url |
http://dx.doi.org/10.1515/ijcre-2017-0179 http://www.degruyter.com/view/j/ijcre.2018.16.issue-7/ijcre-2017-0179/ijcre-2017-0179.xml https://www.degruyter.com/document/doi/10.1515/ijcre-2017-0179/pdf |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
International Journal of Chemical Reactor Engineering volume 16, issue 7 ISSN 1542-6580 |
op_doi |
https://doi.org/10.1515/ijcre-2017-0179 |
container_title |
International Journal of Chemical Reactor Engineering |
container_volume |
16 |
container_issue |
7 |
_version_ |
1795674754142699520 |