Pharmacogenetic testing by polymorphic markers 681G>A and 636G>A CYP2C19 gene in patients with acute coronary syndrome and gastric ulcer in the Republic of Sakha (Yakutia)

• Published in: Drug Metabolism and Personalized Therapy
• Main Authors: Fedorinov, Denis S., Mirzaev, Karin B., Ivashchenko, Dmitriy V., Temirbulatov, Ilyas I., Sychev, Dmitriy A., Maksimova, Nadezda R., Chertovskih, Jana V., Popova, Nyurguiana V., Tayurskaya, Ksenia S., Rudykh, Zoya A.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: Walter de Gruyter GmbH 2018
• Subjects: Pharmacology (medical); General Pharmacology, Toxicology and Pharmaceutics; Sakha; Republic of Sakha; Yakutia; Yakuts
• Online Access: http://dx.doi.org/10.1515/dmpt-2018-0004; http://www.degruyter.com/view/j/dmdi.2018.33.issue-2/dmpt-2018-0004/dmpt-2018-0004.xml; https://www.degruyter.com/document/doi/10.1515/dmpt-2018-0004/pdf

Abstract Background: The focus of the study is to determine the prevalence of CYP2C19 alleles, associated with the risk of changes in the pharmacological response to clopidogrel and proton pump inhibitors in patients with acute coronary syndrome (ACS) and gastric ulcer from Russian and Yakut ethnic groups. Methods: The research included 411 patients with ACS (143 Russians and 268 Yakuts) and 204 patients with histologically confirmed gastric ulcer (63 Russians and 141 Yakuts). Genotyping of 681G>A and 636G>A polymorphisms was performed by using polymerase real-time chain reaction. Results: In both ethnic groups, Hardy-Weinberg equilibrium was followed in a distribution of alleles and genotypes in the population (p>0.05). The 681A allele frequency in the Yakut ethnic group was higher than in the Russian group: 17.53% vs. 8.39% (p=0.001). No statistically significant difference was found in the frequency of 636A in Yakuts and Russians with ACS: 3.92% vs. 3.50% (p=0.840). While comparing the frequency distribution of alleles 681A (13.49% vs. 14.54%, p=0.878) and 636A (7.94% vs. 7.80%, p=1) in patients with a gastric ulcer from Russian and Yakut ethnic groups, no significant difference was found in carrier frequency. Conclusions: The results of the present study may be helpful for developing guidelines for CYPC19 genotype-directed antiplatelet therapy for Yakut and Russian patients.