An ignored risk factor in toxicology: The total imprecision of exposure assessment
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were...
Published in: | Pure and Applied Chemistry |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
Walter de Gruyter GmbH
2010
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1351/pac-con-09-05-04 https://www.degruyter.com/view/journals/pac/82/2/article-p383.xml https://www.degruyter.com/downloadpdf/journals/pac/82/2/article-p383.xml |
id |
crdegruyter:10.1351/pac-con-09-05-04 |
---|---|
record_format |
openpolar |
spelling |
crdegruyter:10.1351/pac-con-09-05-04 2024-09-15T18:05:40+00:00 An ignored risk factor in toxicology: The total imprecision of exposure assessment Grandjean, Philippe Budtz-Jørgensen, Esben 2010 http://dx.doi.org/10.1351/pac-con-09-05-04 https://www.degruyter.com/view/journals/pac/82/2/article-p383.xml https://www.degruyter.com/downloadpdf/journals/pac/82/2/article-p383.xml unknown Walter de Gruyter GmbH Pure and Applied Chemistry volume 82, issue 2, page 383-391 ISSN 1365-3075 0033-4545 journal-article 2010 crdegruyter https://doi.org/10.1351/pac-con-09-05-04 2024-08-12T04:09:03Z Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were determined in cord blood, cord tissue, and maternal hair. We determined their mutual correlations and their associations with the child’s neurobehavioral effect variables at age 7 years. The exposure biomarkers correlated well with one another, but the cord-blood mercury concentration showed the best associations with neurobehavioral deficits. Because at least three exposure parameters were available, factor analysis and structural equation modeling could be applied to determine the total imprecision of each biomarker. For the cord-blood parameter, the total imprecision was 25–30 %, and almost twice as much for maternal hair. The total imprecision of these biomarkers much exceeded the normal laboratory variability of less than 5 %. Such imprecision can cause underestimation of dose-related toxicity, and data analysis should therefore include sensitivity analyses that take this factor into account. Ignoring preanalytical imprecision may cause serious bias. Article in Journal/Newspaper Faroe Islands De Gruyter Pure and Applied Chemistry 82 2 383 391 |
institution |
Open Polar |
collection |
De Gruyter |
op_collection_id |
crdegruyter |
language |
unknown |
description |
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were determined in cord blood, cord tissue, and maternal hair. We determined their mutual correlations and their associations with the child’s neurobehavioral effect variables at age 7 years. The exposure biomarkers correlated well with one another, but the cord-blood mercury concentration showed the best associations with neurobehavioral deficits. Because at least three exposure parameters were available, factor analysis and structural equation modeling could be applied to determine the total imprecision of each biomarker. For the cord-blood parameter, the total imprecision was 25–30 %, and almost twice as much for maternal hair. The total imprecision of these biomarkers much exceeded the normal laboratory variability of less than 5 %. Such imprecision can cause underestimation of dose-related toxicity, and data analysis should therefore include sensitivity analyses that take this factor into account. Ignoring preanalytical imprecision may cause serious bias. |
format |
Article in Journal/Newspaper |
author |
Grandjean, Philippe Budtz-Jørgensen, Esben |
spellingShingle |
Grandjean, Philippe Budtz-Jørgensen, Esben An ignored risk factor in toxicology: The total imprecision of exposure assessment |
author_facet |
Grandjean, Philippe Budtz-Jørgensen, Esben |
author_sort |
Grandjean, Philippe |
title |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_short |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_full |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_fullStr |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_full_unstemmed |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_sort |
ignored risk factor in toxicology: the total imprecision of exposure assessment |
publisher |
Walter de Gruyter GmbH |
publishDate |
2010 |
url |
http://dx.doi.org/10.1351/pac-con-09-05-04 https://www.degruyter.com/view/journals/pac/82/2/article-p383.xml https://www.degruyter.com/downloadpdf/journals/pac/82/2/article-p383.xml |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Pure and Applied Chemistry volume 82, issue 2, page 383-391 ISSN 1365-3075 0033-4545 |
op_doi |
https://doi.org/10.1351/pac-con-09-05-04 |
container_title |
Pure and Applied Chemistry |
container_volume |
82 |
container_issue |
2 |
container_start_page |
383 |
op_container_end_page |
391 |
_version_ |
1810443198301995008 |