Cardiac performance of an isolated heart preparation from the dogfish ( Squalus acanthias ): the effects of hypoxia and coronary artery perfusion
An isolated preparation of the heart of the spiny dogfish, Squalus acanthias, was developed that allowed control of filling and output pressures and perfusion of the coronary arteries. Cardiac output and stroke volume, but not frequency, were dependent upon atrial filling pressure. The mean maximum...
Published in: | Canadian Journal of Zoology |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Canadian Science Publishing
1991
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1139/z91-251 http://www.nrcresearchpress.com/doi/pdf/10.1139/z91-251 |
id |
crcansciencepubl:10.1139/z91-251 |
---|---|
record_format |
openpolar |
spelling |
crcansciencepubl:10.1139/z91-251 2024-04-28T08:41:40+00:00 Cardiac performance of an isolated heart preparation from the dogfish ( Squalus acanthias ): the effects of hypoxia and coronary artery perfusion Davie, Peter S. Farrell, Anthony P. 1991 http://dx.doi.org/10.1139/z91-251 http://www.nrcresearchpress.com/doi/pdf/10.1139/z91-251 en eng Canadian Science Publishing http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining Canadian Journal of Zoology volume 69, issue 7, page 1822-1828 ISSN 0008-4301 1480-3283 Animal Science and Zoology Ecology, Evolution, Behavior and Systematics journal-article 1991 crcansciencepubl https://doi.org/10.1139/z91-251 2024-04-02T06:55:54Z An isolated preparation of the heart of the spiny dogfish, Squalus acanthias, was developed that allowed control of filling and output pressures and perfusion of the coronary arteries. Cardiac output and stroke volume, but not frequency, were dependent upon atrial filling pressure. The mean maximum cardiac power output of 1.76 mW/g ventricle mass was achieved at high stroke volumes and moderate output pressures (29 cmH 2 O). When stroke volume was set at half of its measured maximum, increases in output pressure did not affect stroke volume up to pressures near 46 cmH 2 O, at which point cardiac power output was 1.4 mW/g ventricle mass. In the absence of coronary perfusion, hypoxic perfusion of the heart lumen reduced maximum power output by 38% at 58 ± 3.4 torr and by 64% at 7.7 ± 0.8 torr. Perfusion of the coronary circulation with air-saturated saline or red cell suspensions had no effect on hearts pumping air-saturated saline or hypoxic [Formula: see text] saline, but significantly increased the maximum power output of the hearts pumping severely hypoxic [Formula: see text] saline. Article in Journal/Newspaper spiny dogfish Squalus acanthias Canadian Science Publishing Canadian Journal of Zoology 69 7 1822 1828 |
institution |
Open Polar |
collection |
Canadian Science Publishing |
op_collection_id |
crcansciencepubl |
language |
English |
topic |
Animal Science and Zoology Ecology, Evolution, Behavior and Systematics |
spellingShingle |
Animal Science and Zoology Ecology, Evolution, Behavior and Systematics Davie, Peter S. Farrell, Anthony P. Cardiac performance of an isolated heart preparation from the dogfish ( Squalus acanthias ): the effects of hypoxia and coronary artery perfusion |
topic_facet |
Animal Science and Zoology Ecology, Evolution, Behavior and Systematics |
description |
An isolated preparation of the heart of the spiny dogfish, Squalus acanthias, was developed that allowed control of filling and output pressures and perfusion of the coronary arteries. Cardiac output and stroke volume, but not frequency, were dependent upon atrial filling pressure. The mean maximum cardiac power output of 1.76 mW/g ventricle mass was achieved at high stroke volumes and moderate output pressures (29 cmH 2 O). When stroke volume was set at half of its measured maximum, increases in output pressure did not affect stroke volume up to pressures near 46 cmH 2 O, at which point cardiac power output was 1.4 mW/g ventricle mass. In the absence of coronary perfusion, hypoxic perfusion of the heart lumen reduced maximum power output by 38% at 58 ± 3.4 torr and by 64% at 7.7 ± 0.8 torr. Perfusion of the coronary circulation with air-saturated saline or red cell suspensions had no effect on hearts pumping air-saturated saline or hypoxic [Formula: see text] saline, but significantly increased the maximum power output of the hearts pumping severely hypoxic [Formula: see text] saline. |
format |
Article in Journal/Newspaper |
author |
Davie, Peter S. Farrell, Anthony P. |
author_facet |
Davie, Peter S. Farrell, Anthony P. |
author_sort |
Davie, Peter S. |
title |
Cardiac performance of an isolated heart preparation from the dogfish ( Squalus acanthias ): the effects of hypoxia and coronary artery perfusion |
title_short |
Cardiac performance of an isolated heart preparation from the dogfish ( Squalus acanthias ): the effects of hypoxia and coronary artery perfusion |
title_full |
Cardiac performance of an isolated heart preparation from the dogfish ( Squalus acanthias ): the effects of hypoxia and coronary artery perfusion |
title_fullStr |
Cardiac performance of an isolated heart preparation from the dogfish ( Squalus acanthias ): the effects of hypoxia and coronary artery perfusion |
title_full_unstemmed |
Cardiac performance of an isolated heart preparation from the dogfish ( Squalus acanthias ): the effects of hypoxia and coronary artery perfusion |
title_sort |
cardiac performance of an isolated heart preparation from the dogfish ( squalus acanthias ): the effects of hypoxia and coronary artery perfusion |
publisher |
Canadian Science Publishing |
publishDate |
1991 |
url |
http://dx.doi.org/10.1139/z91-251 http://www.nrcresearchpress.com/doi/pdf/10.1139/z91-251 |
genre |
spiny dogfish Squalus acanthias |
genre_facet |
spiny dogfish Squalus acanthias |
op_source |
Canadian Journal of Zoology volume 69, issue 7, page 1822-1828 ISSN 0008-4301 1480-3283 |
op_rights |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
op_doi |
https://doi.org/10.1139/z91-251 |
container_title |
Canadian Journal of Zoology |
container_volume |
69 |
container_issue |
7 |
container_start_page |
1822 |
op_container_end_page |
1828 |
_version_ |
1797571887068348416 |