Regulation of acid and ion transfer across the membrane of nucleated erythrocytes
The major pathways for proton transport across the membrane of nucleated erythrocytes are the passive Jacobs–Stewart cycle and the secondarily active sodium–proton exchange. The relative importance of these two pathways in the control of red cell pH depends on the sodium–proton exchange rate and the...
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Canadian Science Publishing
1989
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Online Access: | http://dx.doi.org/10.1139/z89-427 http://www.nrcresearchpress.com/doi/pdf/10.1139/z89-427 |
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crcansciencepubl:10.1139/z89-427 2024-09-15T18:01:38+00:00 Regulation of acid and ion transfer across the membrane of nucleated erythrocytes Nikinmaa, Mikko Tufts, Bruce L. 1989 http://dx.doi.org/10.1139/z89-427 http://www.nrcresearchpress.com/doi/pdf/10.1139/z89-427 en eng Canadian Science Publishing http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining Canadian Journal of Zoology volume 67, issue 12, page 3039-3045 ISSN 0008-4301 1480-3283 journal-article 1989 crcansciencepubl https://doi.org/10.1139/z89-427 2024-08-08T04:13:35Z The major pathways for proton transport across the membrane of nucleated erythrocytes are the passive Jacobs–Stewart cycle and the secondarily active sodium–proton exchange. The relative importance of these two pathways in the control of red cell pH depends on the sodium–proton exchange rate and the rate of the slowest step of passive proton equilibration. In cyclostome red cells, which lack anion exchange, intracellular pH is controlled by the sodium-dependent acid–extrusion mechanism. In unstimulated teleost red cells, the Jacobs–Stewart cycle appears to be the most important pathway for the transport of protons across the membrane. Adrenergic stimulation activates sodium–proton exchange. Sodium–proton exchange is able to increase intracellular pH and decrease extracellular pH because the rate of proton transport via the Jacobs–Stewart cycle is limited by the uncatalysed extracellular dehydration of carbonic acid to carbon dioxide. The turnover rate of the adrenergically activated sodium–proton exchange is influenced by pH and oxygen tension. In amphibian red cells, acidification activates sodium–proton exchange. The exchange may limit the changes in intracellular pH after acid–base disturbances. Article in Journal/Newspaper Carbonic acid Canadian Science Publishing Canadian Journal of Zoology 67 12 3039 3045 |
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Open Polar |
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Canadian Science Publishing |
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crcansciencepubl |
language |
English |
description |
The major pathways for proton transport across the membrane of nucleated erythrocytes are the passive Jacobs–Stewart cycle and the secondarily active sodium–proton exchange. The relative importance of these two pathways in the control of red cell pH depends on the sodium–proton exchange rate and the rate of the slowest step of passive proton equilibration. In cyclostome red cells, which lack anion exchange, intracellular pH is controlled by the sodium-dependent acid–extrusion mechanism. In unstimulated teleost red cells, the Jacobs–Stewart cycle appears to be the most important pathway for the transport of protons across the membrane. Adrenergic stimulation activates sodium–proton exchange. Sodium–proton exchange is able to increase intracellular pH and decrease extracellular pH because the rate of proton transport via the Jacobs–Stewart cycle is limited by the uncatalysed extracellular dehydration of carbonic acid to carbon dioxide. The turnover rate of the adrenergically activated sodium–proton exchange is influenced by pH and oxygen tension. In amphibian red cells, acidification activates sodium–proton exchange. The exchange may limit the changes in intracellular pH after acid–base disturbances. |
format |
Article in Journal/Newspaper |
author |
Nikinmaa, Mikko Tufts, Bruce L. |
spellingShingle |
Nikinmaa, Mikko Tufts, Bruce L. Regulation of acid and ion transfer across the membrane of nucleated erythrocytes |
author_facet |
Nikinmaa, Mikko Tufts, Bruce L. |
author_sort |
Nikinmaa, Mikko |
title |
Regulation of acid and ion transfer across the membrane of nucleated erythrocytes |
title_short |
Regulation of acid and ion transfer across the membrane of nucleated erythrocytes |
title_full |
Regulation of acid and ion transfer across the membrane of nucleated erythrocytes |
title_fullStr |
Regulation of acid and ion transfer across the membrane of nucleated erythrocytes |
title_full_unstemmed |
Regulation of acid and ion transfer across the membrane of nucleated erythrocytes |
title_sort |
regulation of acid and ion transfer across the membrane of nucleated erythrocytes |
publisher |
Canadian Science Publishing |
publishDate |
1989 |
url |
http://dx.doi.org/10.1139/z89-427 http://www.nrcresearchpress.com/doi/pdf/10.1139/z89-427 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Canadian Journal of Zoology volume 67, issue 12, page 3039-3045 ISSN 0008-4301 1480-3283 |
op_rights |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
op_doi |
https://doi.org/10.1139/z89-427 |
container_title |
Canadian Journal of Zoology |
container_volume |
67 |
container_issue |
12 |
container_start_page |
3039 |
op_container_end_page |
3045 |
_version_ |
1810438748068904960 |