Paraoxonase phenotype distribution in Canadian Indian and Inuit populations
Test objects were the sera of 57 North American Indian and 67 Inuit subjects. The paraoxon-hydrolyzing activity, a, was determined, as well as the paraoxonase-phenotyping ratio, c/b, a ratio designating enzyme activation by Na + in the presence of Ca 2+ . The values of c/b were clearly bimodally dis...
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Canadian Science Publishing
1983
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crcansciencepubl:10.1139/y83-051 2023-12-17T10:32:28+01:00 Paraoxonase phenotype distribution in Canadian Indian and Inuit populations Carro-Ciampi, Giovanna Gray, Sidney Kalow, Werner 1983 http://dx.doi.org/10.1139/y83-051 http://www.nrcresearchpress.com/doi/pdf/10.1139/y83-051 en eng Canadian Science Publishing http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining Canadian Journal of Physiology and Pharmacology volume 61, issue 4, page 336-340 ISSN 0008-4212 1205-7541 Physiology (medical) Pharmacology General Medicine Physiology journal-article 1983 crcansciencepubl https://doi.org/10.1139/y83-051 2023-11-19T13:39:12Z Test objects were the sera of 57 North American Indian and 67 Inuit subjects. The paraoxon-hydrolyzing activity, a, was determined, as well as the paraoxonase-phenotyping ratio, c/b, a ratio designating enzyme activation by Na + in the presence of Ca 2+ . The values of c/b were clearly bimodally distributed. Location of the modes and of the antimodal gap were in perfect agreement with the results previously obtained on Caucasian sera. This allowed us to retain the criterion which had been already established in the study of Caucasians, i.e., c/b < 1.5 = "low-activity" phenotype, and c/b > 1.5 = "high-activity" phenotype. The proportions of individuals in each mode differed, however. In Caucasians, the frequency of the "low-activity" phenotype had been estimated as 51.2%. In Indians and Inuits, it was 7.0% and 6.0%, respectively. Independent of phenotype, Indian and Inuit sera displayed lower paraoxon-hydrolyzing activity than did Caucasian sera. Article in Journal/Newspaper inuit inuits Canadian Science Publishing (via Crossref) Indian Canadian Journal of Physiology and Pharmacology 61 4 336 340 |
institution |
Open Polar |
collection |
Canadian Science Publishing (via Crossref) |
op_collection_id |
crcansciencepubl |
language |
English |
topic |
Physiology (medical) Pharmacology General Medicine Physiology |
spellingShingle |
Physiology (medical) Pharmacology General Medicine Physiology Carro-Ciampi, Giovanna Gray, Sidney Kalow, Werner Paraoxonase phenotype distribution in Canadian Indian and Inuit populations |
topic_facet |
Physiology (medical) Pharmacology General Medicine Physiology |
description |
Test objects were the sera of 57 North American Indian and 67 Inuit subjects. The paraoxon-hydrolyzing activity, a, was determined, as well as the paraoxonase-phenotyping ratio, c/b, a ratio designating enzyme activation by Na + in the presence of Ca 2+ . The values of c/b were clearly bimodally distributed. Location of the modes and of the antimodal gap were in perfect agreement with the results previously obtained on Caucasian sera. This allowed us to retain the criterion which had been already established in the study of Caucasians, i.e., c/b < 1.5 = "low-activity" phenotype, and c/b > 1.5 = "high-activity" phenotype. The proportions of individuals in each mode differed, however. In Caucasians, the frequency of the "low-activity" phenotype had been estimated as 51.2%. In Indians and Inuits, it was 7.0% and 6.0%, respectively. Independent of phenotype, Indian and Inuit sera displayed lower paraoxon-hydrolyzing activity than did Caucasian sera. |
format |
Article in Journal/Newspaper |
author |
Carro-Ciampi, Giovanna Gray, Sidney Kalow, Werner |
author_facet |
Carro-Ciampi, Giovanna Gray, Sidney Kalow, Werner |
author_sort |
Carro-Ciampi, Giovanna |
title |
Paraoxonase phenotype distribution in Canadian Indian and Inuit populations |
title_short |
Paraoxonase phenotype distribution in Canadian Indian and Inuit populations |
title_full |
Paraoxonase phenotype distribution in Canadian Indian and Inuit populations |
title_fullStr |
Paraoxonase phenotype distribution in Canadian Indian and Inuit populations |
title_full_unstemmed |
Paraoxonase phenotype distribution in Canadian Indian and Inuit populations |
title_sort |
paraoxonase phenotype distribution in canadian indian and inuit populations |
publisher |
Canadian Science Publishing |
publishDate |
1983 |
url |
http://dx.doi.org/10.1139/y83-051 http://www.nrcresearchpress.com/doi/pdf/10.1139/y83-051 |
geographic |
Indian |
geographic_facet |
Indian |
genre |
inuit inuits |
genre_facet |
inuit inuits |
op_source |
Canadian Journal of Physiology and Pharmacology volume 61, issue 4, page 336-340 ISSN 0008-4212 1205-7541 |
op_rights |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
op_doi |
https://doi.org/10.1139/y83-051 |
container_title |
Canadian Journal of Physiology and Pharmacology |
container_volume |
61 |
container_issue |
4 |
container_start_page |
336 |
op_container_end_page |
340 |
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1785586130258755584 |