Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations
CYP2C9 is the major P450 2C enzyme in human liver and contributes to the metabolism of a number of clinically important substrate drugs. This polymorphically expressed enzyme has been studied in Caucasian, Asian, and to some extent in African American populations, but little is known about the genet...
Published in: | Canadian Journal of Physiology and Pharmacology |
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crcansciencepubl:10.1139/y01-065 2024-06-23T07:54:10+00:00 Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations Gaedigk, Andrea Casley, William L Tyndale, Rachel F Sellers, Edward M Jurima-Romet, Malle Leeder, J Steven 2001 http://dx.doi.org/10.1139/y01-065 http://www.nrcresearchpress.com/doi/pdf/10.1139/y01-065 en eng Canadian Science Publishing http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining Canadian Journal of Physiology and Pharmacology volume 79, issue 10, page 841-847 ISSN 0008-4212 1205-7541 journal-article 2001 crcansciencepubl https://doi.org/10.1139/y01-065 2024-06-13T04:10:52Z CYP2C9 is the major P450 2C enzyme in human liver and contributes to the metabolism of a number of clinically important substrate drugs. This polymorphically expressed enzyme has been studied in Caucasian, Asian, and to some extent in African American populations, but little is known about the genetic variation in Native American populations. We therefore determined the 2C9*2 (Arg 144 Cys) and 2C9*3 (Ile 359 Leu) allele frequencies in 153 Native Canadian Indian (CNI) and 151 Inuit subjects by PCR-RFLP techniques. We also present genotyping data for two reference populations, 325 Caucasian (white North American) and 102 Chinese subjects. Genotyping analysis did not reveal any 2C9*4 alleles in the CNI, Inuit, Caucasian, or Chinese individuals. The 2C9*2 allele appears to be absent in Chinese and Inuit populations, but was present in CNI and Caucasian subjects at frequencies of 0.03 and 0.080.15, respectively. The 2C9*3 allele was not detected in the Inuit group, but occured in the CNI group (f = 0.06) at a frequency comparable to that of other ethnic groups. This group of Inuit individuals are the first population in which no 2C9*2 or *3 alleles have been detected so far. Therefore, these alleles may be extremely rare or absent, and unless other novel polymorphisms exist in this Inuit group one would not anticipate any CYP2C9 poor metabolizer subjects among this population.Key words: CYP2C9, polymorphism, genotyping, ethnic diversity. Article in Journal/Newspaper inuit Canadian Science Publishing Indian Canadian Journal of Physiology and Pharmacology 79 10 841 847 |
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CYP2C9 is the major P450 2C enzyme in human liver and contributes to the metabolism of a number of clinically important substrate drugs. This polymorphically expressed enzyme has been studied in Caucasian, Asian, and to some extent in African American populations, but little is known about the genetic variation in Native American populations. We therefore determined the 2C9*2 (Arg 144 Cys) and 2C9*3 (Ile 359 Leu) allele frequencies in 153 Native Canadian Indian (CNI) and 151 Inuit subjects by PCR-RFLP techniques. We also present genotyping data for two reference populations, 325 Caucasian (white North American) and 102 Chinese subjects. Genotyping analysis did not reveal any 2C9*4 alleles in the CNI, Inuit, Caucasian, or Chinese individuals. The 2C9*2 allele appears to be absent in Chinese and Inuit populations, but was present in CNI and Caucasian subjects at frequencies of 0.03 and 0.080.15, respectively. The 2C9*3 allele was not detected in the Inuit group, but occured in the CNI group (f = 0.06) at a frequency comparable to that of other ethnic groups. This group of Inuit individuals are the first population in which no 2C9*2 or *3 alleles have been detected so far. Therefore, these alleles may be extremely rare or absent, and unless other novel polymorphisms exist in this Inuit group one would not anticipate any CYP2C9 poor metabolizer subjects among this population.Key words: CYP2C9, polymorphism, genotyping, ethnic diversity. |
format |
Article in Journal/Newspaper |
author |
Gaedigk, Andrea Casley, William L Tyndale, Rachel F Sellers, Edward M Jurima-Romet, Malle Leeder, J Steven |
spellingShingle |
Gaedigk, Andrea Casley, William L Tyndale, Rachel F Sellers, Edward M Jurima-Romet, Malle Leeder, J Steven Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations |
author_facet |
Gaedigk, Andrea Casley, William L Tyndale, Rachel F Sellers, Edward M Jurima-Romet, Malle Leeder, J Steven |
author_sort |
Gaedigk, Andrea |
title |
Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations |
title_short |
Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations |
title_full |
Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations |
title_fullStr |
Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations |
title_full_unstemmed |
Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations |
title_sort |
cytochrome p4502c9 (cyp2c9) allele frequencies in canadian native indian and inuit populations |
publisher |
Canadian Science Publishing |
publishDate |
2001 |
url |
http://dx.doi.org/10.1139/y01-065 http://www.nrcresearchpress.com/doi/pdf/10.1139/y01-065 |
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Indian |
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Indian |
genre |
inuit |
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inuit |
op_source |
Canadian Journal of Physiology and Pharmacology volume 79, issue 10, page 841-847 ISSN 0008-4212 1205-7541 |
op_rights |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
op_doi |
https://doi.org/10.1139/y01-065 |
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Canadian Journal of Physiology and Pharmacology |
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79 |
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10 |
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841 |
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847 |
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1802646203312111616 |