Frondoside A. A novel triterpene glycoside from the holothurian Cucumaria frondosa

• Published in: Canadian Journal of Chemistry
• Main Authors: Girard, Michel, Bélanger, Jacqueline, ApSimon, John W., Garneau, François-Xavier, Harvey, Christian, Brisson, Jean-Robert
• Format: Article in Journal/Newspaper
• Language: English
• Published: Canadian Science Publishing 1990
• Subjects: Organic Chemistry; General Chemistry; Catalysis; Cucumaria frondosa
• Online Access: http://dx.doi.org/10.1139/v90-003; http://www.nrcresearchpress.com/doi/pdf/10.1139/v90-003

The isolation and characterization of a novel triterpene glycoside from the sea cucumber Cucumariafrondosa, collected from the Gulf of St. Lawrence, are described. Physico-chemical data obtained on the underivatized saponin are presented in support of structure 1 for frondoside A. The structure is characterized by the presence of a branched oligosaccharidic chain composed of five units. The holostane-type aglycone features an endocyclic double bond at position C-7,8 and a β-acetoxy group at C-16. Keywords: triterpene glycoside; Cucumariafrondosa saponins; saponins, triterpene from holothurians; holothurian saponins; echinoderm triterpene saponins.