IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE
Intra-arterially injected cortisone-4-C 14 and cortisol-4-C 14 were cleared from the plasma of sexually mature and spawned sockeye salmon (O. nerka) at a much slower rate than from the plasma of immature sockeye and spawned Atlantic salmon (S. salar). The results explain the elevated hormone levels...
Published in: | Canadian Journal of Biochemistry and Physiology |
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Language: | English |
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Canadian Science Publishing
1963
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Online Access: | http://dx.doi.org/10.1139/o63-100 http://www.nrcresearchpress.com/doi/pdf/10.1139/o63-100 |
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crcansciencepubl:10.1139/o63-100 2024-10-13T14:06:03+00:00 IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE Idler, D. R. Truscott, B. Freeman, H. C. Chang, V. Schmidt, P. J. Ronald, A. P. 1963 http://dx.doi.org/10.1139/o63-100 http://www.nrcresearchpress.com/doi/pdf/10.1139/o63-100 en eng Canadian Science Publishing http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining Canadian Journal of Biochemistry and Physiology volume 41, issue 4, page 875-887 ISSN 0576-5544 journal-article 1963 crcansciencepubl https://doi.org/10.1139/o63-100 2024-09-19T04:09:49Z Intra-arterially injected cortisone-4-C 14 and cortisol-4-C 14 were cleared from the plasma of sexually mature and spawned sockeye salmon (O. nerka) at a much slower rate than from the plasma of immature sockeye and spawned Atlantic salmon (S. salar). The results explain the elevated hormone levels found in the blood of mature and spawned sockeye salmon. The normal clearance rate found with Atlantic salmon, which frequently survive spawning, would indicate that the impaired hormone metabolism was associated with the imminent death of the Pacific salmon rather than with the act of spawning.Testosterone and 17α-hydroxyprogesterone were found to be precursors of 11-ketotestosterone, a sex hormone found in high concentrations in the blood of mature sockeye salmon. Testosterone was also formed in vivo from 17α-hydroxyprogesterone. The results suggest more than one pathway for the synthesis of 11-ketotestosterone in salmon. Cortisol was converted to cortisone but no conversion of the former to 11-ketotestosterone could be demonstrated. Article in Journal/Newspaper Atlantic salmon Canadian Science Publishing Pacific Sockeye ENVELOPE(-130.143,-130.143,54.160,54.160) Canadian Journal of Biochemistry and Physiology 41 4 875 887 |
institution |
Open Polar |
collection |
Canadian Science Publishing |
op_collection_id |
crcansciencepubl |
language |
English |
description |
Intra-arterially injected cortisone-4-C 14 and cortisol-4-C 14 were cleared from the plasma of sexually mature and spawned sockeye salmon (O. nerka) at a much slower rate than from the plasma of immature sockeye and spawned Atlantic salmon (S. salar). The results explain the elevated hormone levels found in the blood of mature and spawned sockeye salmon. The normal clearance rate found with Atlantic salmon, which frequently survive spawning, would indicate that the impaired hormone metabolism was associated with the imminent death of the Pacific salmon rather than with the act of spawning.Testosterone and 17α-hydroxyprogesterone were found to be precursors of 11-ketotestosterone, a sex hormone found in high concentrations in the blood of mature sockeye salmon. Testosterone was also formed in vivo from 17α-hydroxyprogesterone. The results suggest more than one pathway for the synthesis of 11-ketotestosterone in salmon. Cortisol was converted to cortisone but no conversion of the former to 11-ketotestosterone could be demonstrated. |
format |
Article in Journal/Newspaper |
author |
Idler, D. R. Truscott, B. Freeman, H. C. Chang, V. Schmidt, P. J. Ronald, A. P. |
spellingShingle |
Idler, D. R. Truscott, B. Freeman, H. C. Chang, V. Schmidt, P. J. Ronald, A. P. IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE |
author_facet |
Idler, D. R. Truscott, B. Freeman, H. C. Chang, V. Schmidt, P. J. Ronald, A. P. |
author_sort |
Idler, D. R. |
title |
IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE |
title_short |
IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE |
title_full |
IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE |
title_fullStr |
IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE |
title_full_unstemmed |
IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE |
title_sort |
in vivo metabolism of steroid hormones by sockeye salmon: (a) impaired hormone clearance in mature and spawned pacific salmon (o. nerka) (b) precursors of 11-ketotestosterone |
publisher |
Canadian Science Publishing |
publishDate |
1963 |
url |
http://dx.doi.org/10.1139/o63-100 http://www.nrcresearchpress.com/doi/pdf/10.1139/o63-100 |
long_lat |
ENVELOPE(-130.143,-130.143,54.160,54.160) |
geographic |
Pacific Sockeye |
geographic_facet |
Pacific Sockeye |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Canadian Journal of Biochemistry and Physiology volume 41, issue 4, page 875-887 ISSN 0576-5544 |
op_rights |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
op_doi |
https://doi.org/10.1139/o63-100 |
container_title |
Canadian Journal of Biochemistry and Physiology |
container_volume |
41 |
container_issue |
4 |
container_start_page |
875 |
op_container_end_page |
887 |
_version_ |
1812812102698532864 |