Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes
Regulatory volume decrease (RVD) constitutes a fundamental process that turbot ( Scophthalmus maximus ) hepatocytes are able to perform when exposed to hypo-osmotic stress. RVD is an integrative mechanism that involves various elements of the cellular machinery. Among others, ATP is an essential pro...
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crcansciencepubl:10.1139/o09-009 2023-12-17T10:49:43+01:00 Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes Fouchs, Audrey Ollivier, Hélène Theron, Michael Roy, Stella Calvès, Patrick Pichavant-Rafini, Karine 2009 http://dx.doi.org/10.1139/o09-009 http://www.nrcresearchpress.com/doi/full-xml/10.1139/O09-009 http://www.nrcresearchpress.com/doi/pdf/10.1139/O09-009 en eng Canadian Science Publishing http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining Biochemistry and Cell Biology volume 87, issue 3, page 499-504 ISSN 0829-8211 1208-6002 Cell Biology Molecular Biology Biochemistry journal-article 2009 crcansciencepubl https://doi.org/10.1139/o09-009 2023-11-19T13:39:17Z Regulatory volume decrease (RVD) constitutes a fundamental process that turbot ( Scophthalmus maximus ) hepatocytes are able to perform when exposed to hypo-osmotic stress. RVD is an integrative mechanism that involves various elements of the cellular machinery. Among others, ATP is an essential protagonist: released following hypo-osmotic shock, it acts as an auto/paracrine factor to trigger other signalling events. The origin of this ATP remains unclear and, to the best of our knowledge, no information exists about the role of mitochondrial respiration in RVD. Therefore, we propose to analyse the potential link between RVD and the respiratory chain, with a focus on ATP release and exocytosis. Using inhibitors of mitochondrial respiration, RVD was shown to be dependent on respiratory chain activity. However, we demonstrated an indirect role of mitochondrial respiration: ATP could be synthesized and then stored in intracellular vesicles until the moment cells release it to face hypo-osmotic swelling. However, the involvement of exocytosis in this process needs to be further investigated. Article in Journal/Newspaper Scophthalmus maximus Turbot Canadian Science Publishing (via Crossref) Biochemistry and Cell Biology 87 3 499 504 |
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Open Polar |
collection |
Canadian Science Publishing (via Crossref) |
op_collection_id |
crcansciencepubl |
language |
English |
topic |
Cell Biology Molecular Biology Biochemistry |
spellingShingle |
Cell Biology Molecular Biology Biochemistry Fouchs, Audrey Ollivier, Hélène Theron, Michael Roy, Stella Calvès, Patrick Pichavant-Rafini, Karine Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes |
topic_facet |
Cell Biology Molecular Biology Biochemistry |
description |
Regulatory volume decrease (RVD) constitutes a fundamental process that turbot ( Scophthalmus maximus ) hepatocytes are able to perform when exposed to hypo-osmotic stress. RVD is an integrative mechanism that involves various elements of the cellular machinery. Among others, ATP is an essential protagonist: released following hypo-osmotic shock, it acts as an auto/paracrine factor to trigger other signalling events. The origin of this ATP remains unclear and, to the best of our knowledge, no information exists about the role of mitochondrial respiration in RVD. Therefore, we propose to analyse the potential link between RVD and the respiratory chain, with a focus on ATP release and exocytosis. Using inhibitors of mitochondrial respiration, RVD was shown to be dependent on respiratory chain activity. However, we demonstrated an indirect role of mitochondrial respiration: ATP could be synthesized and then stored in intracellular vesicles until the moment cells release it to face hypo-osmotic swelling. However, the involvement of exocytosis in this process needs to be further investigated. |
format |
Article in Journal/Newspaper |
author |
Fouchs, Audrey Ollivier, Hélène Theron, Michael Roy, Stella Calvès, Patrick Pichavant-Rafini, Karine |
author_facet |
Fouchs, Audrey Ollivier, Hélène Theron, Michael Roy, Stella Calvès, Patrick Pichavant-Rafini, Karine |
author_sort |
Fouchs, Audrey |
title |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes |
title_short |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes |
title_full |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes |
title_fullStr |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes |
title_full_unstemmed |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes |
title_sort |
involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes |
publisher |
Canadian Science Publishing |
publishDate |
2009 |
url |
http://dx.doi.org/10.1139/o09-009 http://www.nrcresearchpress.com/doi/full-xml/10.1139/O09-009 http://www.nrcresearchpress.com/doi/pdf/10.1139/O09-009 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
Biochemistry and Cell Biology volume 87, issue 3, page 499-504 ISSN 0829-8211 1208-6002 |
op_rights |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
op_doi |
https://doi.org/10.1139/o09-009 |
container_title |
Biochemistry and Cell Biology |
container_volume |
87 |
container_issue |
3 |
container_start_page |
499 |
op_container_end_page |
504 |
_version_ |
1785574269716004864 |