Effects of Dietary Iron Concentrations on the Cytochrome P450 System of Atlantic Salmon ( Salmo salar )
Groups of Atlantic salmon (Salmo salar) parr were fed a basal diet containing 27 mg Fe∙kg feed −1 supplemented with different iron levels (0, 80, and 160 mg∙kg −1 , respectively) for 8 wk. After this period, a subgroup of each iron regime was treated intraperitoneally with β-naphthoflavone (BNF), a...
Published in: | Canadian Journal of Fisheries and Aquatic Sciences |
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Canadian Science Publishing
1994
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Online Access: | http://dx.doi.org/10.1139/f94-032 http://www.nrcresearchpress.com/doi/pdf/10.1139/f94-032 |
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crcansciencepubl:10.1139/f94-032 2024-03-03T08:42:47+00:00 Effects of Dietary Iron Concentrations on the Cytochrome P450 System of Atlantic Salmon ( Salmo salar ) Goksøyr, Anders Bjørnevik, Marit Maage, Amund 1994 http://dx.doi.org/10.1139/f94-032 http://www.nrcresearchpress.com/doi/pdf/10.1139/f94-032 en eng Canadian Science Publishing http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining Canadian Journal of Fisheries and Aquatic Sciences volume 51, issue 2, page 315-320 ISSN 0706-652X 1205-7533 Aquatic Science Ecology, Evolution, Behavior and Systematics journal-article 1994 crcansciencepubl https://doi.org/10.1139/f94-032 2024-02-07T10:53:39Z Groups of Atlantic salmon (Salmo salar) parr were fed a basal diet containing 27 mg Fe∙kg feed −1 supplemented with different iron levels (0, 80, and 160 mg∙kg −1 , respectively) for 8 wk. After this period, a subgroup of each iron regime was treated intraperitoneally with β-naphthoflavone (BNF), a potent inducer of cytochrome P450 1A1 in fish. Differences between the iron regimes were observed in hepatic iron content, which was higher in the high-iron group, and in P450 1A1 levels and monooxygenase activity, measured as 7-ethoxyresorufin O-deethylase (EROD), which were lower in the high-iron group. Differences were also observed in the induction response of P450 1A1 and EROD to BNF. Levels of a constitutive isozyme denoted P450con, belonging to the P450 3A subfamily, did not respond to the dietary iron in the same manner, demonstrating selective regulatory effects of iron on different P450 isozymes. Article in Journal/Newspaper Atlantic salmon Salmo salar Canadian Science Publishing Canadian Journal of Fisheries and Aquatic Sciences 51 2 315 320 |
institution |
Open Polar |
collection |
Canadian Science Publishing |
op_collection_id |
crcansciencepubl |
language |
English |
topic |
Aquatic Science Ecology, Evolution, Behavior and Systematics |
spellingShingle |
Aquatic Science Ecology, Evolution, Behavior and Systematics Goksøyr, Anders Bjørnevik, Marit Maage, Amund Effects of Dietary Iron Concentrations on the Cytochrome P450 System of Atlantic Salmon ( Salmo salar ) |
topic_facet |
Aquatic Science Ecology, Evolution, Behavior and Systematics |
description |
Groups of Atlantic salmon (Salmo salar) parr were fed a basal diet containing 27 mg Fe∙kg feed −1 supplemented with different iron levels (0, 80, and 160 mg∙kg −1 , respectively) for 8 wk. After this period, a subgroup of each iron regime was treated intraperitoneally with β-naphthoflavone (BNF), a potent inducer of cytochrome P450 1A1 in fish. Differences between the iron regimes were observed in hepatic iron content, which was higher in the high-iron group, and in P450 1A1 levels and monooxygenase activity, measured as 7-ethoxyresorufin O-deethylase (EROD), which were lower in the high-iron group. Differences were also observed in the induction response of P450 1A1 and EROD to BNF. Levels of a constitutive isozyme denoted P450con, belonging to the P450 3A subfamily, did not respond to the dietary iron in the same manner, demonstrating selective regulatory effects of iron on different P450 isozymes. |
format |
Article in Journal/Newspaper |
author |
Goksøyr, Anders Bjørnevik, Marit Maage, Amund |
author_facet |
Goksøyr, Anders Bjørnevik, Marit Maage, Amund |
author_sort |
Goksøyr, Anders |
title |
Effects of Dietary Iron Concentrations on the Cytochrome P450 System of Atlantic Salmon ( Salmo salar ) |
title_short |
Effects of Dietary Iron Concentrations on the Cytochrome P450 System of Atlantic Salmon ( Salmo salar ) |
title_full |
Effects of Dietary Iron Concentrations on the Cytochrome P450 System of Atlantic Salmon ( Salmo salar ) |
title_fullStr |
Effects of Dietary Iron Concentrations on the Cytochrome P450 System of Atlantic Salmon ( Salmo salar ) |
title_full_unstemmed |
Effects of Dietary Iron Concentrations on the Cytochrome P450 System of Atlantic Salmon ( Salmo salar ) |
title_sort |
effects of dietary iron concentrations on the cytochrome p450 system of atlantic salmon ( salmo salar ) |
publisher |
Canadian Science Publishing |
publishDate |
1994 |
url |
http://dx.doi.org/10.1139/f94-032 http://www.nrcresearchpress.com/doi/pdf/10.1139/f94-032 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Canadian Journal of Fisheries and Aquatic Sciences volume 51, issue 2, page 315-320 ISSN 0706-652X 1205-7533 |
op_rights |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
op_doi |
https://doi.org/10.1139/f94-032 |
container_title |
Canadian Journal of Fisheries and Aquatic Sciences |
container_volume |
51 |
container_issue |
2 |
container_start_page |
315 |
op_container_end_page |
320 |
_version_ |
1792498242515107840 |