n -EICOS-11-ENOIC ACID

• Published in: Canadian Journal of Research
• Main Authors: Hopkins, C. Y., Chisholm, Mary J., Harris, John
• Format: Article in Journal/Newspaper
• Language: English
• Published: Canadian Science Publishing 1949
• Subjects: Pharmacology (medical); Complementary and alternative medicine; Pharmaceutical Science; Pacific; atlantic cod
• Online Access: http://dx.doi.org/10.1139/cjr49b-005; http://www.nrcresearchpress.com/doi/pdf/10.1139/cjr49b-005

Natural sources of cis-n-eicos-11-enoic acid, a convenient method of isolating the acid, and its conversion to the trans-form are described. It was found that the principal eicosenoic acid of a sample of Atlantic cod liver oil (Gadus callarias) was the Δ 11 isomer, in contrast to the reports of other workers who investigated Pacific codfish and found only the Δ 9 isomer. The following derivatives are reported: cis-n-eicos-11-enoic anilide, N-hydroxyamide, epoxide, chlorohydrin; 11,12-dihydroxyeicosanoic acid (low-melting isomer), and its amide; trans-n-eicos-11-enoic acid, its hydrazide, and N-hydroxyamide. Some new physical constants of the cis-acid and its methyl ester are given.