n -EICOS-11-ENOIC ACID

Natural sources of cis-n-eicos-11-enoic acid, a convenient method of isolating the acid, and its conversion to the trans-form are described. It was found that the principal eicosenoic acid of a sample of Atlantic cod liver oil (Gadus callarias) was the Δ 11 isomer, in contrast to the reports of othe...

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Bibliographic Details
Published in:Canadian Journal of Research
Main Authors: Hopkins, C. Y., Chisholm, Mary J., Harris, John
Format: Article in Journal/Newspaper
Language:English
Published: Canadian Science Publishing 1949
Subjects:
Pharmacology (medical)
Complementary and alternative medicine
Pharmaceutical Science
Pacific
atlantic cod
Online Access:http://dx.doi.org/10.1139/cjr49b-005
http://www.nrcresearchpress.com/doi/pdf/10.1139/cjr49b-005
Description
Summary:Natural sources of cis-n-eicos-11-enoic acid, a convenient method of isolating the acid, and its conversion to the trans-form are described. It was found that the principal eicosenoic acid of a sample of Atlantic cod liver oil (Gadus callarias) was the Δ 11 isomer, in contrast to the reports of other workers who investigated Pacific codfish and found only the Δ 9 isomer. The following derivatives are reported: cis-n-eicos-11-enoic anilide, N-hydroxyamide, epoxide, chlorohydrin; 11,12-dihydroxyeicosanoic acid (low-melting isomer), and its amide; trans-n-eicos-11-enoic acid, its hydrazide, and N-hydroxyamide. Some new physical constants of the cis-acid and its methyl ester are given.

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