POLIOMYELITIS IN CANADIAN ESKIMOS
This paper describes further laboratory studies undertaken to investigate the immunological aspects of the outbreak of poliomyelitis in the Canadian Eastern Arctic in the winter of 1948-1949. No evidence was found that any of three strains of virus recovered from Eskimos was pathogenic for cotton ra...
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Language: | English |
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Canadian Science Publishing
1951
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Online Access: | http://dx.doi.org/10.1139/cjms51-027 http://www.nrcresearchpress.com/doi/pdf/10.1139/cjms51-027 |
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crcansciencepubl:10.1139/cjms51-027 2023-12-17T10:26:11+01:00 POLIOMYELITIS IN CANADIAN ESKIMOS LABORATORY STUDIES. II. Clark, Eina M. Rhodes, A. J. 1951 http://dx.doi.org/10.1139/cjms51-027 http://www.nrcresearchpress.com/doi/pdf/10.1139/cjms51-027 en eng Canadian Science Publishing http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining Canadian Journal of Medical Sciences volume 29, issue 4, page 216-235 ISSN 0316-4403 General Medicine journal-article 1951 crcansciencepubl https://doi.org/10.1139/cjms51-027 2023-11-19T13:39:12Z This paper describes further laboratory studies undertaken to investigate the immunological aspects of the outbreak of poliomyelitis in the Canadian Eastern Arctic in the winter of 1948-1949. No evidence was found that any of three strains of virus recovered from Eskimos was pathogenic for cotton rats or mice. No strains of Coxsackie virus were recovered. Main attention is directed to the examination of 51 sera from 40 persons (34 Eskimos) involved in the outbreak for the presence of neutralizing antibody to Lansing poliomyelitis virus. Antibody was found in the acute phase serum of two of three patients, and in the con valescent phase serum of about half of those tested. The serum of six of eight healthy Eskimos and five of six white contacts contained antibody. It seemed that antibody started to appear in the serum from the age of 10 onwards, the serum of most adults proving positive. It is concluded that the presence of Lansing antibody in the serum of the Eskimos was the result of previous exposure to Lansing virus and was unrelated to the current epidemic. The world-wide prevalence of Lansing antibody and by inference of Lansing virus is evident. Article in Journal/Newspaper Arctic eskimo* Canadian Science Publishing (via Crossref) Arctic Lansing ENVELOPE(-133.476,-133.476,63.744,63.744) Canadian Journal of Medical Sciences 29 4 216 235 |
institution |
Open Polar |
collection |
Canadian Science Publishing (via Crossref) |
op_collection_id |
crcansciencepubl |
language |
English |
topic |
General Medicine |
spellingShingle |
General Medicine Clark, Eina M. Rhodes, A. J. POLIOMYELITIS IN CANADIAN ESKIMOS |
topic_facet |
General Medicine |
description |
This paper describes further laboratory studies undertaken to investigate the immunological aspects of the outbreak of poliomyelitis in the Canadian Eastern Arctic in the winter of 1948-1949. No evidence was found that any of three strains of virus recovered from Eskimos was pathogenic for cotton rats or mice. No strains of Coxsackie virus were recovered. Main attention is directed to the examination of 51 sera from 40 persons (34 Eskimos) involved in the outbreak for the presence of neutralizing antibody to Lansing poliomyelitis virus. Antibody was found in the acute phase serum of two of three patients, and in the con valescent phase serum of about half of those tested. The serum of six of eight healthy Eskimos and five of six white contacts contained antibody. It seemed that antibody started to appear in the serum from the age of 10 onwards, the serum of most adults proving positive. It is concluded that the presence of Lansing antibody in the serum of the Eskimos was the result of previous exposure to Lansing virus and was unrelated to the current epidemic. The world-wide prevalence of Lansing antibody and by inference of Lansing virus is evident. |
format |
Article in Journal/Newspaper |
author |
Clark, Eina M. Rhodes, A. J. |
author_facet |
Clark, Eina M. Rhodes, A. J. |
author_sort |
Clark, Eina M. |
title |
POLIOMYELITIS IN CANADIAN ESKIMOS |
title_short |
POLIOMYELITIS IN CANADIAN ESKIMOS |
title_full |
POLIOMYELITIS IN CANADIAN ESKIMOS |
title_fullStr |
POLIOMYELITIS IN CANADIAN ESKIMOS |
title_full_unstemmed |
POLIOMYELITIS IN CANADIAN ESKIMOS |
title_sort |
poliomyelitis in canadian eskimos |
publisher |
Canadian Science Publishing |
publishDate |
1951 |
url |
http://dx.doi.org/10.1139/cjms51-027 http://www.nrcresearchpress.com/doi/pdf/10.1139/cjms51-027 |
long_lat |
ENVELOPE(-133.476,-133.476,63.744,63.744) |
geographic |
Arctic Lansing |
geographic_facet |
Arctic Lansing |
genre |
Arctic eskimo* |
genre_facet |
Arctic eskimo* |
op_source |
Canadian Journal of Medical Sciences volume 29, issue 4, page 216-235 ISSN 0316-4403 |
op_rights |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
op_doi |
https://doi.org/10.1139/cjms51-027 |
container_title |
Canadian Journal of Medical Sciences |
container_volume |
29 |
container_issue |
4 |
container_start_page |
216 |
op_container_end_page |
235 |
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1785577897852928000 |