Candida antarctica lipase B-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxy groups
Candida antarctica lipase B proved to be highly active in the deacylation of substituted hydroquinones and resorcinols acylated at both phenolic hydroxy groups. The deacylation reactions were much faster than the corresponding direct acylations of these dihydroxybenzenes catalyzed by the same lipase...
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crcansciencepubl:10.1139/cjc-2015-0335 2024-06-23T07:47:57+00:00 Candida antarctica lipase B-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxy groups Miyazawa, Toshifumi Hamada, Manabu Morimoto, Ryohei 2016 http://dx.doi.org/10.1139/cjc-2015-0335 http://www.nrcresearchpress.com/doi/full-xml/10.1139/cjc-2015-0335 http://www.nrcresearchpress.com/doi/pdf/10.1139/cjc-2015-0335 en eng Canadian Science Publishing http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining Canadian Journal of Chemistry volume 94, issue 1, page 44-49 ISSN 0008-4042 1480-3291 journal-article 2016 crcansciencepubl https://doi.org/10.1139/cjc-2015-0335 2024-06-13T04:10:53Z Candida antarctica lipase B proved to be highly active in the deacylation of substituted hydroquinones and resorcinols acylated at both phenolic hydroxy groups. The deacylation reactions were much faster than the corresponding direct acylations of these dihydroxybenzenes catalyzed by the same lipase. More importantly, they took place generally in a markedly regioselective manner: the acyloxy group remote from the substituent was preferentially cleaved. The main or exclusive products obtained were the regioisomers of those produced through the direct acylation of the dihydroxybenzenes. In the case of alkyl-substituted hydroquinone derivatives, the regioselectivity increased with an increase in the bulk of the substituent. In the case of 4-substituted diacylated resorcinols, the 3-O-monoacyl derivatives were obtained generally as the sole products. Quite interestingly, some secondary alcohols proved to act as better acyl acceptors than the corresponding primary alcohols in these enzymatic deacylations. Article in Journal/Newspaper Antarc* Antarctica Canadian Science Publishing Canadian Journal of Chemistry 94 1 44 49 |
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English |
description |
Candida antarctica lipase B proved to be highly active in the deacylation of substituted hydroquinones and resorcinols acylated at both phenolic hydroxy groups. The deacylation reactions were much faster than the corresponding direct acylations of these dihydroxybenzenes catalyzed by the same lipase. More importantly, they took place generally in a markedly regioselective manner: the acyloxy group remote from the substituent was preferentially cleaved. The main or exclusive products obtained were the regioisomers of those produced through the direct acylation of the dihydroxybenzenes. In the case of alkyl-substituted hydroquinone derivatives, the regioselectivity increased with an increase in the bulk of the substituent. In the case of 4-substituted diacylated resorcinols, the 3-O-monoacyl derivatives were obtained generally as the sole products. Quite interestingly, some secondary alcohols proved to act as better acyl acceptors than the corresponding primary alcohols in these enzymatic deacylations. |
format |
Article in Journal/Newspaper |
author |
Miyazawa, Toshifumi Hamada, Manabu Morimoto, Ryohei |
spellingShingle |
Miyazawa, Toshifumi Hamada, Manabu Morimoto, Ryohei Candida antarctica lipase B-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxy groups |
author_facet |
Miyazawa, Toshifumi Hamada, Manabu Morimoto, Ryohei |
author_sort |
Miyazawa, Toshifumi |
title |
Candida antarctica lipase B-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxy groups |
title_short |
Candida antarctica lipase B-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxy groups |
title_full |
Candida antarctica lipase B-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxy groups |
title_fullStr |
Candida antarctica lipase B-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxy groups |
title_full_unstemmed |
Candida antarctica lipase B-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxy groups |
title_sort |
candida antarctica lipase b-catalyzed regioselective deacylation of dihydroxybenzenes acylated at both phenolic hydroxy groups |
publisher |
Canadian Science Publishing |
publishDate |
2016 |
url |
http://dx.doi.org/10.1139/cjc-2015-0335 http://www.nrcresearchpress.com/doi/full-xml/10.1139/cjc-2015-0335 http://www.nrcresearchpress.com/doi/pdf/10.1139/cjc-2015-0335 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Canadian Journal of Chemistry volume 94, issue 1, page 44-49 ISSN 0008-4042 1480-3291 |
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http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
op_doi |
https://doi.org/10.1139/cjc-2015-0335 |
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Canadian Journal of Chemistry |
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94 |
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44 |
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49 |
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1802638237739515904 |