Burkholderia cepacia Infections Associated With Intrinsically Contaminated Ultrasound Gel: The Role of Microbial Degradation of Parabens
Abstract Objective: To describe an outbreak of serious nosocomial Burkholderia cepacia infections occurring after transrectal prostate biopsy associated with ultrasound gel intrinsically contaminated with paraben-degrading microorganisms. Methods: A retrospective chart review prompted by a blood cul...
Published in: | Infection Control & Hospital Epidemiology |
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Online Access: | http://dx.doi.org/10.1086/502394 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0195941700083776 |
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crcambridgeupr:10.1086/502394 2024-09-15T18:20:10+00:00 Burkholderia cepacia Infections Associated With Intrinsically Contaminated Ultrasound Gel: The Role of Microbial Degradation of Parabens Hutchinson, Jim Runge, Wendy Mulvey, Mike Norris, Gail Yetman, Marion Valkova, Nelly Villemur, Richard Lepine, Francois 2004 http://dx.doi.org/10.1086/502394 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0195941700083776 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms Infection Control & Hospital Epidemiology volume 25, issue 4, page 291-296 ISSN 0899-823X 1559-6834 journal-article 2004 crcambridgeupr https://doi.org/10.1086/502394 2024-07-31T04:04:27Z Abstract Objective: To describe an outbreak of serious nosocomial Burkholderia cepacia infections occurring after transrectal prostate biopsy associated with ultrasound gel intrinsically contaminated with paraben-degrading microorganisms. Methods: A retrospective chart review prompted by a blood culture isolate of B, cepacia. Identification of microorganisms in ultrasound gel in two Canadian centers and characterization by pulsed-field gel electrophoresis and assays for paraben degradation. Setting: Two Canadian university-affiliated, tertiary-care centers in Newfoundland and Alberta. Results: Six serious B. cepacia infections were identified at the two centers. Isolates of B. cepacia recovered from the blood of patients from both centers and the ultrasound gel used during the procedures were identical, confirming intrinsic contamination. Strains of Enterobacter cloacae isolated from ultrasound gel at the two centers were also identical. The ability to degrade parabens was proven for both B. cepacia and E. cloacae strains recovered from the ultrasound gel. Conclusions: Ultrasound gel is a potential source of infection. Contamination occurs at the time of manufacture, with organisms that degrade parabens, which are commonly used as stabilizing agents. There are far-reaching implications for the infection control community. Article in Journal/Newspaper Newfoundland Cambridge University Press Infection Control & Hospital Epidemiology 25 4 291 296 |
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Cambridge University Press |
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English |
description |
Abstract Objective: To describe an outbreak of serious nosocomial Burkholderia cepacia infections occurring after transrectal prostate biopsy associated with ultrasound gel intrinsically contaminated with paraben-degrading microorganisms. Methods: A retrospective chart review prompted by a blood culture isolate of B, cepacia. Identification of microorganisms in ultrasound gel in two Canadian centers and characterization by pulsed-field gel electrophoresis and assays for paraben degradation. Setting: Two Canadian university-affiliated, tertiary-care centers in Newfoundland and Alberta. Results: Six serious B. cepacia infections were identified at the two centers. Isolates of B. cepacia recovered from the blood of patients from both centers and the ultrasound gel used during the procedures were identical, confirming intrinsic contamination. Strains of Enterobacter cloacae isolated from ultrasound gel at the two centers were also identical. The ability to degrade parabens was proven for both B. cepacia and E. cloacae strains recovered from the ultrasound gel. Conclusions: Ultrasound gel is a potential source of infection. Contamination occurs at the time of manufacture, with organisms that degrade parabens, which are commonly used as stabilizing agents. There are far-reaching implications for the infection control community. |
format |
Article in Journal/Newspaper |
author |
Hutchinson, Jim Runge, Wendy Mulvey, Mike Norris, Gail Yetman, Marion Valkova, Nelly Villemur, Richard Lepine, Francois |
spellingShingle |
Hutchinson, Jim Runge, Wendy Mulvey, Mike Norris, Gail Yetman, Marion Valkova, Nelly Villemur, Richard Lepine, Francois Burkholderia cepacia Infections Associated With Intrinsically Contaminated Ultrasound Gel: The Role of Microbial Degradation of Parabens |
author_facet |
Hutchinson, Jim Runge, Wendy Mulvey, Mike Norris, Gail Yetman, Marion Valkova, Nelly Villemur, Richard Lepine, Francois |
author_sort |
Hutchinson, Jim |
title |
Burkholderia cepacia Infections Associated With Intrinsically Contaminated Ultrasound Gel: The Role of Microbial Degradation of Parabens |
title_short |
Burkholderia cepacia Infections Associated With Intrinsically Contaminated Ultrasound Gel: The Role of Microbial Degradation of Parabens |
title_full |
Burkholderia cepacia Infections Associated With Intrinsically Contaminated Ultrasound Gel: The Role of Microbial Degradation of Parabens |
title_fullStr |
Burkholderia cepacia Infections Associated With Intrinsically Contaminated Ultrasound Gel: The Role of Microbial Degradation of Parabens |
title_full_unstemmed |
Burkholderia cepacia Infections Associated With Intrinsically Contaminated Ultrasound Gel: The Role of Microbial Degradation of Parabens |
title_sort |
burkholderia cepacia infections associated with intrinsically contaminated ultrasound gel: the role of microbial degradation of parabens |
publisher |
Cambridge University Press (CUP) |
publishDate |
2004 |
url |
http://dx.doi.org/10.1086/502394 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0195941700083776 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Infection Control & Hospital Epidemiology volume 25, issue 4, page 291-296 ISSN 0899-823X 1559-6834 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1086/502394 |
container_title |
Infection Control & Hospital Epidemiology |
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25 |
container_issue |
4 |
container_start_page |
291 |
op_container_end_page |
296 |
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1810458538882891776 |