Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case–control study
Milk fat is high in saturated fatty acids (SFA) and high intakes of SFA are associated with cardiovascular diseases. The aim of the present study was to prospectively evaluate the potential risk of a first-ever acute myocardial infarction (AMI) in relation to the estimated milk-fat intake, reflected...
Published in: | British Journal of Nutrition |
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Language: | English |
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Cambridge University Press (CUP)
2004
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Online Access: | http://dx.doi.org/10.1079/bjn20041080 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114504000790 |
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crcambridgeupr:10.1079/bjn20041080 2024-09-15T18:26:12+00:00 Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case–control study Warensjö, Eva Jansson, Jan-Håkan Berglund, Lars Boman, Kurt Ahrén, Bo Weinehall, Lars Lindahl, Bernt Hallmans, Göran Vessby, Bengt 2004 http://dx.doi.org/10.1079/bjn20041080 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114504000790 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 91, issue 4, page 635-642 ISSN 0007-1145 1475-2662 journal-article 2004 crcambridgeupr https://doi.org/10.1079/bjn20041080 2024-07-24T04:03:46Z Milk fat is high in saturated fatty acids (SFA) and high intakes of SFA are associated with cardiovascular diseases. The aim of the present study was to prospectively evaluate the potential risk of a first-ever acute myocardial infarction (AMI) in relation to the estimated milk-fat intake, reflected as the proportions of pentadecanoic acid (15:0) and heptadecanoic acid (17:0) in serum lipid esters. This was evaluated in a study population selected within the Västerbotten Intervention Program and the northern Sweden ‘Monitoring of Trends and Determinants in Cardiovascular disease’ survey populations. A prospective case–control design was used. The proportions of the biomarkers were lower in the cases ( n 78) than in the controls ( n 156), who were matched for age, sex, sampling time and geographical region. The standardised odds ratios of becoming an AMI case were between 0·7 and 0·8 for the biomarkers. The proportions of 15:0 and 17:0 in serum phospholipids were significantly and negatively correlated to serum concentrations of plasminogen activator inhibitor-1, tissue-type plasminogen activator, triacylglycerols, insulin, specific insulin, pro-insulin and leptin (all P <0·0001), suggesting a negative relationship to the insulin-resistance syndrome and the risk of CHD. Adjustment for BMI did not materially change the relationships. Although there seems to be a negative association between milk-fat intake as mirrored by the proportions of 15:0 and 17:0 in serum lipid esters and a first-ever AMI, adjustment for clinical risk factors removed this relationship. Article in Journal/Newspaper Northern Sweden Cambridge University Press British Journal of Nutrition 91 4 635 642 |
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Open Polar |
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Cambridge University Press |
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crcambridgeupr |
language |
English |
description |
Milk fat is high in saturated fatty acids (SFA) and high intakes of SFA are associated with cardiovascular diseases. The aim of the present study was to prospectively evaluate the potential risk of a first-ever acute myocardial infarction (AMI) in relation to the estimated milk-fat intake, reflected as the proportions of pentadecanoic acid (15:0) and heptadecanoic acid (17:0) in serum lipid esters. This was evaluated in a study population selected within the Västerbotten Intervention Program and the northern Sweden ‘Monitoring of Trends and Determinants in Cardiovascular disease’ survey populations. A prospective case–control design was used. The proportions of the biomarkers were lower in the cases ( n 78) than in the controls ( n 156), who were matched for age, sex, sampling time and geographical region. The standardised odds ratios of becoming an AMI case were between 0·7 and 0·8 for the biomarkers. The proportions of 15:0 and 17:0 in serum phospholipids were significantly and negatively correlated to serum concentrations of plasminogen activator inhibitor-1, tissue-type plasminogen activator, triacylglycerols, insulin, specific insulin, pro-insulin and leptin (all P <0·0001), suggesting a negative relationship to the insulin-resistance syndrome and the risk of CHD. Adjustment for BMI did not materially change the relationships. Although there seems to be a negative association between milk-fat intake as mirrored by the proportions of 15:0 and 17:0 in serum lipid esters and a first-ever AMI, adjustment for clinical risk factors removed this relationship. |
format |
Article in Journal/Newspaper |
author |
Warensjö, Eva Jansson, Jan-Håkan Berglund, Lars Boman, Kurt Ahrén, Bo Weinehall, Lars Lindahl, Bernt Hallmans, Göran Vessby, Bengt |
spellingShingle |
Warensjö, Eva Jansson, Jan-Håkan Berglund, Lars Boman, Kurt Ahrén, Bo Weinehall, Lars Lindahl, Bernt Hallmans, Göran Vessby, Bengt Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case–control study |
author_facet |
Warensjö, Eva Jansson, Jan-Håkan Berglund, Lars Boman, Kurt Ahrén, Bo Weinehall, Lars Lindahl, Bernt Hallmans, Göran Vessby, Bengt |
author_sort |
Warensjö, Eva |
title |
Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case–control study |
title_short |
Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case–control study |
title_full |
Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case–control study |
title_fullStr |
Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case–control study |
title_full_unstemmed |
Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case–control study |
title_sort |
estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. a prospective case–control study |
publisher |
Cambridge University Press (CUP) |
publishDate |
2004 |
url |
http://dx.doi.org/10.1079/bjn20041080 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114504000790 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
British Journal of Nutrition volume 91, issue 4, page 635-642 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1079/bjn20041080 |
container_title |
British Journal of Nutrition |
container_volume |
91 |
container_issue |
4 |
container_start_page |
635 |
op_container_end_page |
642 |
_version_ |
1810466649519685632 |