Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model
Abstract Elevated levels of organochlorines (OC) have been reported in Inuit populations in the Arctic. We hypothesized that prenatal exposure to a Canadian Arctic OC mixture adversely affects male reproductive function and health with age. Sprague–Dawley female rats (F0) were gavaged with an enviro...
Published in: | Journal of Developmental Origins of Health and Disease |
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Language: | English |
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Online Access: | http://dx.doi.org/10.1017/s2040174418000491 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S2040174418000491 |
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crcambridgeupr:10.1017/s2040174418000491 2024-06-23T07:49:31+00:00 Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model Maurice, C. Kaczmarczyk, M. Côté, N. Tremblay, Y. Kimmins, S. Bailey, J. L. 2018 http://dx.doi.org/10.1017/s2040174418000491 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S2040174418000491 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms Journal of Developmental Origins of Health and Disease volume 9, issue 5, page 511-518 ISSN 2040-1744 2040-1752 journal-article 2018 crcambridgeupr https://doi.org/10.1017/s2040174418000491 2024-06-05T04:04:17Z Abstract Elevated levels of organochlorines (OC) have been reported in Inuit populations in the Arctic. We hypothesized that prenatal exposure to a Canadian Arctic OC mixture adversely affects male reproductive function and health with age. Sprague–Dawley female rats (F0) were gavaged with an environmentally relevant concentration of an Arctic OC mixture or corn oil (Control) during mating with untreated males until parturition (F1 litters). After postnatal day (PND) 90, the weights of the OC F1 males differed dramatically relative to Controls ( P <0.05; n =10) and they exhibited respiratory distress. Except for possible thinning of the alveolar barrier, histological observation of the lungs revealed no apparent pathology to explain the respiratory distress. At PND 365, OC F1 males had reduced relative reproductive organ weights and lower sperm quality than Controls ( P <0.05). At PND 90, OC F1 males were subfertile ( P <0.05), but were infertile at PND 365. In conclusion, environmentally relevant prenatal OC exposure reduced reproductive function and health in aging male rats, providing new insight into the effects of early-life exposures to these contaminants. Article in Journal/Newspaper Arctic inuit Cambridge University Press Arctic Journal of Developmental Origins of Health and Disease 9 5 511 518 |
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Open Polar |
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Cambridge University Press |
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crcambridgeupr |
language |
English |
description |
Abstract Elevated levels of organochlorines (OC) have been reported in Inuit populations in the Arctic. We hypothesized that prenatal exposure to a Canadian Arctic OC mixture adversely affects male reproductive function and health with age. Sprague–Dawley female rats (F0) were gavaged with an environmentally relevant concentration of an Arctic OC mixture or corn oil (Control) during mating with untreated males until parturition (F1 litters). After postnatal day (PND) 90, the weights of the OC F1 males differed dramatically relative to Controls ( P <0.05; n =10) and they exhibited respiratory distress. Except for possible thinning of the alveolar barrier, histological observation of the lungs revealed no apparent pathology to explain the respiratory distress. At PND 365, OC F1 males had reduced relative reproductive organ weights and lower sperm quality than Controls ( P <0.05). At PND 90, OC F1 males were subfertile ( P <0.05), but were infertile at PND 365. In conclusion, environmentally relevant prenatal OC exposure reduced reproductive function and health in aging male rats, providing new insight into the effects of early-life exposures to these contaminants. |
format |
Article in Journal/Newspaper |
author |
Maurice, C. Kaczmarczyk, M. Côté, N. Tremblay, Y. Kimmins, S. Bailey, J. L. |
spellingShingle |
Maurice, C. Kaczmarczyk, M. Côté, N. Tremblay, Y. Kimmins, S. Bailey, J. L. Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model |
author_facet |
Maurice, C. Kaczmarczyk, M. Côté, N. Tremblay, Y. Kimmins, S. Bailey, J. L. |
author_sort |
Maurice, C. |
title |
Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model |
title_short |
Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model |
title_full |
Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model |
title_fullStr |
Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model |
title_full_unstemmed |
Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model |
title_sort |
prenatal exposure to an environmentally relevant mixture of canadian arctic contaminants decreases male reproductive function in an aging rat model |
publisher |
Cambridge University Press (CUP) |
publishDate |
2018 |
url |
http://dx.doi.org/10.1017/s2040174418000491 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S2040174418000491 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic inuit |
genre_facet |
Arctic inuit |
op_source |
Journal of Developmental Origins of Health and Disease volume 9, issue 5, page 511-518 ISSN 2040-1744 2040-1752 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s2040174418000491 |
container_title |
Journal of Developmental Origins of Health and Disease |
container_volume |
9 |
container_issue |
5 |
container_start_page |
511 |
op_container_end_page |
518 |
_version_ |
1802639986127798272 |