High protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk Canadian Inuit population
Abstract Objective The rate of type 2 diabetes mellitus among Inuit is 12·2 % in individuals over 50 years of age, similar to the Canadian prevalence. Given marked dietary transitions in the Arctic, we evaluated the dietary and other correlates of not previously diagnosed glucose intolerance, define...
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crcambridgeupr:10.1017/s1368980015003080 2023-05-15T15:13:56+02:00 High protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk Canadian Inuit population Sefidbakht, Saghar Johnson-Down, Louise Young, T Kue Egeland, Grace M 2015 http://dx.doi.org/10.1017/s1368980015003080 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1368980015003080 en eng Cambridge University Press (CUP) http://creativecommons.org/licenses/by/4.0/ CC-BY Public Health Nutrition volume 19, issue 10, page 1804-1811 ISSN 1368-9800 1475-2727 Public Health, Environmental and Occupational Health Nutrition and Dietetics Medicine (miscellaneous) journal-article 2015 crcambridgeupr https://doi.org/10.1017/s1368980015003080 2022-04-07T08:54:23Z Abstract Objective The rate of type 2 diabetes mellitus among Inuit is 12·2 % in individuals over 50 years of age, similar to the Canadian prevalence. Given marked dietary transitions in the Arctic, we evaluated the dietary and other correlates of not previously diagnosed glucose intolerance, defined as type 2 diabetes mellitus, impaired fasting glucose or impaired glucose tolerance. Design Cross-sectional analyses were limited to adults with a completed 2 h oral glucose tolerance test and without pre-existing diabetes. Anthropometric assessments, health and medication usage questionnaires and a 24 h dietary recall were administered. Setting Canadian International Polar Year Inuit Health Survey (2007–2008). Subjects Inuit adults ( n 777). Results Glucose intolerance was associated with older age and adiposity. Percentage of energy from protein above the Acceptable Macronutrient Distribution Range of 35 %, compared with intake within the range, was associated with increased odds of glucose intolerance (OR=1·98; 95 % CI 1·09, 3·61) in multivariable analyses. Further, cholesterol intake in the highest three quartiles combined (median exposures of 207, 416 and 778 mg/d, respectively) compared with the lowest quartile (median intake of 81 mg/d) was associated with glucose intolerance (OR=2·15; 95 % CI 1·23, 3·78) in multivariable analyses. Past-day traditional food consumption was borderline protective of glucose intolerance ( P= 0·054) and high fibre intake was not significantly protective ( P =0·08). Conclusions The results contribute to the existing literature on high protein and cholesterol intakes as they may relate to diabetes risk. Article in Journal/Newspaper Arctic International Polar Year inuit Cambridge University Press (via Crossref) Arctic Public Health Nutrition 19 10 1804 1811 |
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Open Polar |
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Cambridge University Press (via Crossref) |
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crcambridgeupr |
language |
English |
topic |
Public Health, Environmental and Occupational Health Nutrition and Dietetics Medicine (miscellaneous) |
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Public Health, Environmental and Occupational Health Nutrition and Dietetics Medicine (miscellaneous) Sefidbakht, Saghar Johnson-Down, Louise Young, T Kue Egeland, Grace M High protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk Canadian Inuit population |
topic_facet |
Public Health, Environmental and Occupational Health Nutrition and Dietetics Medicine (miscellaneous) |
description |
Abstract Objective The rate of type 2 diabetes mellitus among Inuit is 12·2 % in individuals over 50 years of age, similar to the Canadian prevalence. Given marked dietary transitions in the Arctic, we evaluated the dietary and other correlates of not previously diagnosed glucose intolerance, defined as type 2 diabetes mellitus, impaired fasting glucose or impaired glucose tolerance. Design Cross-sectional analyses were limited to adults with a completed 2 h oral glucose tolerance test and without pre-existing diabetes. Anthropometric assessments, health and medication usage questionnaires and a 24 h dietary recall were administered. Setting Canadian International Polar Year Inuit Health Survey (2007–2008). Subjects Inuit adults ( n 777). Results Glucose intolerance was associated with older age and adiposity. Percentage of energy from protein above the Acceptable Macronutrient Distribution Range of 35 %, compared with intake within the range, was associated with increased odds of glucose intolerance (OR=1·98; 95 % CI 1·09, 3·61) in multivariable analyses. Further, cholesterol intake in the highest three quartiles combined (median exposures of 207, 416 and 778 mg/d, respectively) compared with the lowest quartile (median intake of 81 mg/d) was associated with glucose intolerance (OR=2·15; 95 % CI 1·23, 3·78) in multivariable analyses. Past-day traditional food consumption was borderline protective of glucose intolerance ( P= 0·054) and high fibre intake was not significantly protective ( P =0·08). Conclusions The results contribute to the existing literature on high protein and cholesterol intakes as they may relate to diabetes risk. |
format |
Article in Journal/Newspaper |
author |
Sefidbakht, Saghar Johnson-Down, Louise Young, T Kue Egeland, Grace M |
author_facet |
Sefidbakht, Saghar Johnson-Down, Louise Young, T Kue Egeland, Grace M |
author_sort |
Sefidbakht, Saghar |
title |
High protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk Canadian Inuit population |
title_short |
High protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk Canadian Inuit population |
title_full |
High protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk Canadian Inuit population |
title_fullStr |
High protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk Canadian Inuit population |
title_full_unstemmed |
High protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk Canadian Inuit population |
title_sort |
high protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk canadian inuit population |
publisher |
Cambridge University Press (CUP) |
publishDate |
2015 |
url |
http://dx.doi.org/10.1017/s1368980015003080 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1368980015003080 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic International Polar Year inuit |
genre_facet |
Arctic International Polar Year inuit |
op_source |
Public Health Nutrition volume 19, issue 10, page 1804-1811 ISSN 1368-9800 1475-2727 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1017/s1368980015003080 |
container_title |
Public Health Nutrition |
container_volume |
19 |
container_issue |
10 |
container_start_page |
1804 |
op_container_end_page |
1811 |
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1766344446458200064 |