Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic
Abstract Selenium is an essential mineral yet both deficiency and excess are associated with adverse health effects. Dietary intake of Se in humans varies greatly between populations due to food availability, dietary preferences, and local geological and ecosystem processes impacting Se accumulation...
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Cambridge University Press (CUP)
2024
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Online Access: | http://dx.doi.org/10.1017/s0954422424000039 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0954422424000039 |
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crcambridgeupr:10.1017/s0954422424000039 2024-05-19T07:35:47+00:00 Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic Little, Matthew Achouba, Adel Ayotte, Pierre Lemire, Mélanie 2024 http://dx.doi.org/10.1017/s0954422424000039 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0954422424000039 en eng Cambridge University Press (CUP) http://creativecommons.org/licenses/by/4.0/ Nutrition Research Reviews page 1-10 ISSN 0954-4224 1475-2700 journal-article 2024 crcambridgeupr https://doi.org/10.1017/s0954422424000039 2024-05-02T06:50:55Z Abstract Selenium is an essential mineral yet both deficiency and excess are associated with adverse health effects. Dietary intake of Se in humans varies greatly between populations due to food availability, dietary preferences, and local geological and ecosystem processes impacting Se accumulation into agricultural products and animal populations. We argue there is a need to evaluate and reconsider the relevance of public health recommendations on Se given recent evidence, including the metabolic pathways and health implications of Se. This argument is particularly pertinent for Inuit populations in Northern Canada, who often exceed dietary tolerable upper intake levels and exhibit very high whole blood Se concentrations due to their dependence on local country foods high in the newly discovered Se compound, selenoneine. Since selenoneine appears to have lower toxicity compared to other Se species and does not contribute to the circulating pools of Se for selenoprotein synthesis, we argue that total dietary Se or total Se in plasma or whole blood are poor indicators of Se adequacy for human health in these populations. Overall, this review provides an overview of the current evidence of Se speciation, deficiency, adequacy, and excess and implications for human health and dietary recommendations, with particular reference to Inuit populations in the Canadian Arctic and other coastal populations consuming marine foods. Article in Journal/Newspaper Arctic Human health inuit Cambridge University Press Nutrition Research Reviews 1 10 |
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Cambridge University Press |
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English |
description |
Abstract Selenium is an essential mineral yet both deficiency and excess are associated with adverse health effects. Dietary intake of Se in humans varies greatly between populations due to food availability, dietary preferences, and local geological and ecosystem processes impacting Se accumulation into agricultural products and animal populations. We argue there is a need to evaluate and reconsider the relevance of public health recommendations on Se given recent evidence, including the metabolic pathways and health implications of Se. This argument is particularly pertinent for Inuit populations in Northern Canada, who often exceed dietary tolerable upper intake levels and exhibit very high whole blood Se concentrations due to their dependence on local country foods high in the newly discovered Se compound, selenoneine. Since selenoneine appears to have lower toxicity compared to other Se species and does not contribute to the circulating pools of Se for selenoprotein synthesis, we argue that total dietary Se or total Se in plasma or whole blood are poor indicators of Se adequacy for human health in these populations. Overall, this review provides an overview of the current evidence of Se speciation, deficiency, adequacy, and excess and implications for human health and dietary recommendations, with particular reference to Inuit populations in the Canadian Arctic and other coastal populations consuming marine foods. |
format |
Article in Journal/Newspaper |
author |
Little, Matthew Achouba, Adel Ayotte, Pierre Lemire, Mélanie |
spellingShingle |
Little, Matthew Achouba, Adel Ayotte, Pierre Lemire, Mélanie Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic |
author_facet |
Little, Matthew Achouba, Adel Ayotte, Pierre Lemire, Mélanie |
author_sort |
Little, Matthew |
title |
Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic |
title_short |
Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic |
title_full |
Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic |
title_fullStr |
Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic |
title_full_unstemmed |
Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic |
title_sort |
emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary se among inuit populations in the canadian arctic |
publisher |
Cambridge University Press (CUP) |
publishDate |
2024 |
url |
http://dx.doi.org/10.1017/s0954422424000039 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0954422424000039 |
genre |
Arctic Human health inuit |
genre_facet |
Arctic Human health inuit |
op_source |
Nutrition Research Reviews page 1-10 ISSN 0954-4224 1475-2700 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1017/s0954422424000039 |
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Nutrition Research Reviews |
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10 |
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