Hantavirus– Leptospira coinfections in small mammals from central Germany
Abstract European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans. We investi...
Published in: | Epidemiology and Infection |
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Cambridge University Press (CUP)
2021
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Online Access: | http://dx.doi.org/10.1017/s0950268821000443 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0950268821000443 |
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crcambridgeupr:10.1017/s0950268821000443 2024-05-12T08:07:02+00:00 Hantavirus– Leptospira coinfections in small mammals from central Germany Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. 2021 http://dx.doi.org/10.1017/s0950268821000443 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0950268821000443 en eng Cambridge University Press (CUP) http://creativecommons.org/licenses/by/4.0/ Epidemiology and Infection volume 149 ISSN 0950-2688 1469-4409 Infectious Diseases Epidemiology journal-article 2021 crcambridgeupr https://doi.org/10.1017/s0950268821000443 2024-04-18T06:53:59Z Abstract European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans. We investigated the frequency of Leptospira spp. and hantavirus single and double infections in small mammals from 22 sites in Thuringia, central Germany, during 2017. TULV infections were detected at 18 of 22 sites (mean prevalence 13.8%, 93/674). PUUV infections were detected at four of 22 sites (mean prevalence 1.5%, 7/471), and respective PUUV sequences formed a novel phylogenetic clade, but DOBV infections were not detected at all. Leptospira infections were detected at 21 of 22 sites with the highest overall prevalence in field voles ( Microtus agrestis ) with 54.5% (6/11) and common voles ( Microtus arvalis ) with 30.3% (205/676). Leptospira –hantavirus coinfections were found in 6.6% (44/671) of common voles but only in two of 395 bank voles. TULV and Leptospira coinfection probability in common voles was driven by individual (age) and population-level factors. Coinfections seemed to be particularly associated with sites where Leptospira spp. prevalence exceeded 35%. Future investigations should evaluate public health consequences of this strong spatial clustering of coinfections. Article in Journal/Newspaper Microtus arvalis Cambridge University Press Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) Epidemiology and Infection 149 |
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Cambridge University Press |
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crcambridgeupr |
language |
English |
topic |
Infectious Diseases Epidemiology |
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Infectious Diseases Epidemiology Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. Hantavirus– Leptospira coinfections in small mammals from central Germany |
topic_facet |
Infectious Diseases Epidemiology |
description |
Abstract European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans. We investigated the frequency of Leptospira spp. and hantavirus single and double infections in small mammals from 22 sites in Thuringia, central Germany, during 2017. TULV infections were detected at 18 of 22 sites (mean prevalence 13.8%, 93/674). PUUV infections were detected at four of 22 sites (mean prevalence 1.5%, 7/471), and respective PUUV sequences formed a novel phylogenetic clade, but DOBV infections were not detected at all. Leptospira infections were detected at 21 of 22 sites with the highest overall prevalence in field voles ( Microtus agrestis ) with 54.5% (6/11) and common voles ( Microtus arvalis ) with 30.3% (205/676). Leptospira –hantavirus coinfections were found in 6.6% (44/671) of common voles but only in two of 395 bank voles. TULV and Leptospira coinfection probability in common voles was driven by individual (age) and population-level factors. Coinfections seemed to be particularly associated with sites where Leptospira spp. prevalence exceeded 35%. Future investigations should evaluate public health consequences of this strong spatial clustering of coinfections. |
format |
Article in Journal/Newspaper |
author |
Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. |
author_facet |
Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. |
author_sort |
Jeske, K. |
title |
Hantavirus– Leptospira coinfections in small mammals from central Germany |
title_short |
Hantavirus– Leptospira coinfections in small mammals from central Germany |
title_full |
Hantavirus– Leptospira coinfections in small mammals from central Germany |
title_fullStr |
Hantavirus– Leptospira coinfections in small mammals from central Germany |
title_full_unstemmed |
Hantavirus– Leptospira coinfections in small mammals from central Germany |
title_sort |
hantavirus– leptospira coinfections in small mammals from central germany |
publisher |
Cambridge University Press (CUP) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1017/s0950268821000443 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0950268821000443 |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_source |
Epidemiology and Infection volume 149 ISSN 0950-2688 1469-4409 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1017/s0950268821000443 |
container_title |
Epidemiology and Infection |
container_volume |
149 |
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1798849595168522240 |