The Relation of Ultraviolet Radiation and Multiple Sclerosis in Newfoundland
Background : It has been thought that the occurrence of multiple sclerosis (MS) could be associated with daily ultraviolet exposure. In this study we investigated the geospatial association between average daily ultraviolet B (UVB) irradiance and MS prevalence in Newfoundland and Labrador (NL), Cana...
Published in: | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques |
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Cambridge University Press (CUP)
2008
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Online Access: | http://dx.doi.org/10.1017/s0317167100007587 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0317167100007587 |
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crcambridgeupr:10.1017/s0317167100007587 2024-06-23T07:54:44+00:00 The Relation of Ultraviolet Radiation and Multiple Sclerosis in Newfoundland Sloka, JS Pryse-Phillips, WEM Stefanelli, M 2008 http://dx.doi.org/10.1017/s0317167100007587 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0317167100007587 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques volume 35, issue 1, page 69-74 ISSN 0317-1671 2057-0155 journal-article 2008 crcambridgeupr https://doi.org/10.1017/s0317167100007587 2024-06-12T04:05:10Z Background : It has been thought that the occurrence of multiple sclerosis (MS) could be associated with daily ultraviolet exposure. In this study we investigated the geospatial association between average daily ultraviolet B (UVB) irradiance and MS prevalence in Newfoundland and Labrador (NL), Canada. Methods : A complete list of patients diagnosed with MS in the province of NL was constructed. Places of habitation from birth to diagnosis were ascertained by mailout survey. Results : A 74% rate of return on the survey results was obtained. A plot of the average daily erythemal UV over the available five years (1998-2002) shows that the distribution of MS follow a north-south gradient. Average daily UVB measurements are lower in the higher latitudes. A statistically significant negative correlation of MS incidence with erythemal UVB was found that is stronger than the correlation using latitude. This correlation appears to be strongest in the first year of life and declines when subsequent years are examined up to age ten. No significant correlation was found for the subjects' locale of habitation at the time of their first MS attack. Conclusions : This study suggests that UVB radiation may contribute to the pathogenesis of MS. Article in Journal/Newspaper Newfoundland Cambridge University Press Canada Newfoundland Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 35 1 69 74 |
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Cambridge University Press |
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crcambridgeupr |
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English |
description |
Background : It has been thought that the occurrence of multiple sclerosis (MS) could be associated with daily ultraviolet exposure. In this study we investigated the geospatial association between average daily ultraviolet B (UVB) irradiance and MS prevalence in Newfoundland and Labrador (NL), Canada. Methods : A complete list of patients diagnosed with MS in the province of NL was constructed. Places of habitation from birth to diagnosis were ascertained by mailout survey. Results : A 74% rate of return on the survey results was obtained. A plot of the average daily erythemal UV over the available five years (1998-2002) shows that the distribution of MS follow a north-south gradient. Average daily UVB measurements are lower in the higher latitudes. A statistically significant negative correlation of MS incidence with erythemal UVB was found that is stronger than the correlation using latitude. This correlation appears to be strongest in the first year of life and declines when subsequent years are examined up to age ten. No significant correlation was found for the subjects' locale of habitation at the time of their first MS attack. Conclusions : This study suggests that UVB radiation may contribute to the pathogenesis of MS. |
format |
Article in Journal/Newspaper |
author |
Sloka, JS Pryse-Phillips, WEM Stefanelli, M |
spellingShingle |
Sloka, JS Pryse-Phillips, WEM Stefanelli, M The Relation of Ultraviolet Radiation and Multiple Sclerosis in Newfoundland |
author_facet |
Sloka, JS Pryse-Phillips, WEM Stefanelli, M |
author_sort |
Sloka, JS |
title |
The Relation of Ultraviolet Radiation and Multiple Sclerosis in Newfoundland |
title_short |
The Relation of Ultraviolet Radiation and Multiple Sclerosis in Newfoundland |
title_full |
The Relation of Ultraviolet Radiation and Multiple Sclerosis in Newfoundland |
title_fullStr |
The Relation of Ultraviolet Radiation and Multiple Sclerosis in Newfoundland |
title_full_unstemmed |
The Relation of Ultraviolet Radiation and Multiple Sclerosis in Newfoundland |
title_sort |
relation of ultraviolet radiation and multiple sclerosis in newfoundland |
publisher |
Cambridge University Press (CUP) |
publishDate |
2008 |
url |
http://dx.doi.org/10.1017/s0317167100007587 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0317167100007587 |
geographic |
Canada Newfoundland |
geographic_facet |
Canada Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques volume 35, issue 1, page 69-74 ISSN 0317-1671 2057-0155 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0317167100007587 |
container_title |
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques |
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35 |
container_issue |
1 |
container_start_page |
69 |
op_container_end_page |
74 |
_version_ |
1802646998579412992 |