Health-related quality of life in elderly patients with familial hypercholesterolemia
Objectives: There are very few descriptions on how familial hypercholesterolemia (FH), a genetic disorder with an increased risk of coronary heart disease (CHD), affects older patients. The aim of this study was to analyze the health-related quality of life (HRQoL) of elderly patients with FH. Metho...
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crcambridgeupr:10.1017/s0266462308080318 2024-03-03T08:46:13+00:00 Health-related quality of life in elderly patients with familial hypercholesterolemia Hyttinen, Laura Kekäläinen, Päivi Vuorio, Alpo F. Sintonen, Harri Strandberg, Timo E. 2008 http://dx.doi.org/10.1017/s0266462308080318 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0266462308080318 en eng Cambridge University Press (CUP) International Journal of Technology Assessment in Health Care volume 24, issue 02, page 228-234 ISSN 0266-4623 1471-6348 Health Policy journal-article 2008 crcambridgeupr https://doi.org/10.1017/s0266462308080318 2024-02-08T08:44:55Z Objectives: There are very few descriptions on how familial hypercholesterolemia (FH), a genetic disorder with an increased risk of coronary heart disease (CHD), affects older patients. The aim of this study was to analyze the health-related quality of life (HRQoL) of elderly patients with FH. Methods: All FH patients with the same FH North Karelia-mutation aged 65 and over living in North Karelia province in Eastern Finland were asked to participate in the study in 2003. They were compared with age-standardized controls from the Finnish general population. A total of forty-three elderly FH patients were identified and thirty-seven of them (aged 65 to 84 years, M/F 10/27) agreed to participate. Most of them (27/37) had been diagnosed with CHD. All but one of these FH patients had been using statins for approximately 15 years. HRQoL was assessed with the RAND-36 (SF-36) and 15D instruments. Results: Despite the clear cardiovascular morbidity and low socioeconomic status, these FH patients enjoyed a similar HRQoL as the age-standardized controls in the general population. Conclusions: Lifelong hypercholesterolemia was not associated with poorer HRQoL in elderly survivors of FH. These elderly FH individuals were characterized by their healthy lifestyle and long-term statin treatment. Article in Journal/Newspaper karelia* Cambridge University Press International Journal of Technology Assessment in Health Care 24 02 228 234 |
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Cambridge University Press |
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English |
topic |
Health Policy |
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Health Policy Hyttinen, Laura Kekäläinen, Päivi Vuorio, Alpo F. Sintonen, Harri Strandberg, Timo E. Health-related quality of life in elderly patients with familial hypercholesterolemia |
topic_facet |
Health Policy |
description |
Objectives: There are very few descriptions on how familial hypercholesterolemia (FH), a genetic disorder with an increased risk of coronary heart disease (CHD), affects older patients. The aim of this study was to analyze the health-related quality of life (HRQoL) of elderly patients with FH. Methods: All FH patients with the same FH North Karelia-mutation aged 65 and over living in North Karelia province in Eastern Finland were asked to participate in the study in 2003. They were compared with age-standardized controls from the Finnish general population. A total of forty-three elderly FH patients were identified and thirty-seven of them (aged 65 to 84 years, M/F 10/27) agreed to participate. Most of them (27/37) had been diagnosed with CHD. All but one of these FH patients had been using statins for approximately 15 years. HRQoL was assessed with the RAND-36 (SF-36) and 15D instruments. Results: Despite the clear cardiovascular morbidity and low socioeconomic status, these FH patients enjoyed a similar HRQoL as the age-standardized controls in the general population. Conclusions: Lifelong hypercholesterolemia was not associated with poorer HRQoL in elderly survivors of FH. These elderly FH individuals were characterized by their healthy lifestyle and long-term statin treatment. |
format |
Article in Journal/Newspaper |
author |
Hyttinen, Laura Kekäläinen, Päivi Vuorio, Alpo F. Sintonen, Harri Strandberg, Timo E. |
author_facet |
Hyttinen, Laura Kekäläinen, Päivi Vuorio, Alpo F. Sintonen, Harri Strandberg, Timo E. |
author_sort |
Hyttinen, Laura |
title |
Health-related quality of life in elderly patients with familial hypercholesterolemia |
title_short |
Health-related quality of life in elderly patients with familial hypercholesterolemia |
title_full |
Health-related quality of life in elderly patients with familial hypercholesterolemia |
title_fullStr |
Health-related quality of life in elderly patients with familial hypercholesterolemia |
title_full_unstemmed |
Health-related quality of life in elderly patients with familial hypercholesterolemia |
title_sort |
health-related quality of life in elderly patients with familial hypercholesterolemia |
publisher |
Cambridge University Press (CUP) |
publishDate |
2008 |
url |
http://dx.doi.org/10.1017/s0266462308080318 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0266462308080318 |
genre |
karelia* |
genre_facet |
karelia* |
op_source |
International Journal of Technology Assessment in Health Care volume 24, issue 02, page 228-234 ISSN 0266-4623 1471-6348 |
op_doi |
https://doi.org/10.1017/s0266462308080318 |
container_title |
International Journal of Technology Assessment in Health Care |
container_volume |
24 |
container_issue |
02 |
container_start_page |
228 |
op_container_end_page |
234 |
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1792502205427744768 |