Cystic echinococcosis in Iceland: a brief history and genetic analysis of a 46-year-old Echinococcus isolate collected prior to the eradication of this zoonotic disease
Abstract Cystic echinococcosis (CE) is considered the most severe parasitic disease that ever affected the human population in Iceland. Before the start of eradication campaign in the 1860s, Iceland was a country with very high prevalence of human CE, with approximately every fifth person infected....
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Online Access: | http://dx.doi.org/10.1017/s0031182023000355 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0031182023000355 |
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crcambridgeupr:10.1017/s0031182023000355 2024-03-03T08:45:32+00:00 Cystic echinococcosis in Iceland: a brief history and genetic analysis of a 46-year-old Echinococcus isolate collected prior to the eradication of this zoonotic disease Saarma, Urmas Skirnisson, Karl Björnsdottir, Thorunn Soley Laurimäe, Teivi Kinkar, Liina 2023 http://dx.doi.org/10.1017/s0031182023000355 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0031182023000355 en eng Cambridge University Press (CUP) http://creativecommons.org/licenses/by/4.0/ Parasitology volume 150, issue 7, page 638-643 ISSN 0031-1820 1469-8161 Infectious Diseases Animal Science and Zoology Parasitology journal-article 2023 crcambridgeupr https://doi.org/10.1017/s0031182023000355 2024-02-08T08:41:14Z Abstract Cystic echinococcosis (CE) is considered the most severe parasitic disease that ever affected the human population in Iceland. Before the start of eradication campaign in the 1860s, Iceland was a country with very high prevalence of human CE, with approximately every fifth person infected. Eradication of CE from Iceland by 1979 was a huge success story and served as a leading example for other countries on how to combat such a severe One Health problem. However, there is no genetic information on Echinococcus parasites before eradication. Here, we reveal the genetic identity for one of the last Echinococcus isolates in Iceland, obtained from a sheep 46 years ago (1977). We sequenced a large portion of the mitochondrial genome (8141 bp) and identified the isolate as Echinococcus granulosus sensu stricto genotype G1. As G1 is known to be highly infective genotype to humans, it may partly explain why such a large proportion of human population in Iceland was infected at a time . The study demonstrates that decades-old samples hold significant potential to uncover genetic identities of parasites in the past. Article in Journal/Newspaper Iceland Cambridge University Press Parasitology 1 6 |
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Open Polar |
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Cambridge University Press |
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language |
English |
topic |
Infectious Diseases Animal Science and Zoology Parasitology |
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Infectious Diseases Animal Science and Zoology Parasitology Saarma, Urmas Skirnisson, Karl Björnsdottir, Thorunn Soley Laurimäe, Teivi Kinkar, Liina Cystic echinococcosis in Iceland: a brief history and genetic analysis of a 46-year-old Echinococcus isolate collected prior to the eradication of this zoonotic disease |
topic_facet |
Infectious Diseases Animal Science and Zoology Parasitology |
description |
Abstract Cystic echinococcosis (CE) is considered the most severe parasitic disease that ever affected the human population in Iceland. Before the start of eradication campaign in the 1860s, Iceland was a country with very high prevalence of human CE, with approximately every fifth person infected. Eradication of CE from Iceland by 1979 was a huge success story and served as a leading example for other countries on how to combat such a severe One Health problem. However, there is no genetic information on Echinococcus parasites before eradication. Here, we reveal the genetic identity for one of the last Echinococcus isolates in Iceland, obtained from a sheep 46 years ago (1977). We sequenced a large portion of the mitochondrial genome (8141 bp) and identified the isolate as Echinococcus granulosus sensu stricto genotype G1. As G1 is known to be highly infective genotype to humans, it may partly explain why such a large proportion of human population in Iceland was infected at a time . The study demonstrates that decades-old samples hold significant potential to uncover genetic identities of parasites in the past. |
format |
Article in Journal/Newspaper |
author |
Saarma, Urmas Skirnisson, Karl Björnsdottir, Thorunn Soley Laurimäe, Teivi Kinkar, Liina |
author_facet |
Saarma, Urmas Skirnisson, Karl Björnsdottir, Thorunn Soley Laurimäe, Teivi Kinkar, Liina |
author_sort |
Saarma, Urmas |
title |
Cystic echinococcosis in Iceland: a brief history and genetic analysis of a 46-year-old Echinococcus isolate collected prior to the eradication of this zoonotic disease |
title_short |
Cystic echinococcosis in Iceland: a brief history and genetic analysis of a 46-year-old Echinococcus isolate collected prior to the eradication of this zoonotic disease |
title_full |
Cystic echinococcosis in Iceland: a brief history and genetic analysis of a 46-year-old Echinococcus isolate collected prior to the eradication of this zoonotic disease |
title_fullStr |
Cystic echinococcosis in Iceland: a brief history and genetic analysis of a 46-year-old Echinococcus isolate collected prior to the eradication of this zoonotic disease |
title_full_unstemmed |
Cystic echinococcosis in Iceland: a brief history and genetic analysis of a 46-year-old Echinococcus isolate collected prior to the eradication of this zoonotic disease |
title_sort |
cystic echinococcosis in iceland: a brief history and genetic analysis of a 46-year-old echinococcus isolate collected prior to the eradication of this zoonotic disease |
publisher |
Cambridge University Press (CUP) |
publishDate |
2023 |
url |
http://dx.doi.org/10.1017/s0031182023000355 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0031182023000355 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Parasitology volume 150, issue 7, page 638-643 ISSN 0031-1820 1469-8161 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1017/s0031182023000355 |
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Parasitology |
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1792501110217375744 |