Molecular ecology of Schistosoma mansoni transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts
We investigated the genotypic composition of the digenetic parasite Schistosoma mansoni for its adult stages within the definitive host (the wild rat, Rattus rattus ) and for the larval stages within the intermediate host (the snail, Biomphalaria glabrata ) both collected at the same transmission si...
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crcambridgeupr:10.1017/s0031182004005943 2024-03-03T08:48:26+00:00 Molecular ecology of Schistosoma mansoni transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts THERON, A. SIRE, C. ROGNON, A. PRUGNOLLE, F. DURAND, P. 2004 http://dx.doi.org/10.1017/s0031182004005943 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0031182004005943 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms Parasitology volume 129, issue 5, page 571-585 ISSN 0031-1820 1469-8161 Infectious Diseases Animal Science and Zoology Parasitology journal-article 2004 crcambridgeupr https://doi.org/10.1017/s0031182004005943 2024-02-08T08:34:23Z We investigated the genotypic composition of the digenetic parasite Schistosoma mansoni for its adult stages within the definitive host (the wild rat, Rattus rattus ) and for the larval stages within the intermediate host (the snail, Biomphalaria glabrata ) both collected at the same transmission site. Our analyses are based upon the recognition and distribution of 200 different multilocus genotypes generated by RAPD markers. While intramolluscan larval infrapopulations are characterized by a low infection rate (0·6% on average) and low intra-host genetic diversity (1·1 genotype on average per infected snail), adult infrapopulations within rats showed a high infection rate (94%) and a substantial intra-host genetic diversity (34 genotypes on average) linked to high intensities (160 worms per host on average). A single definitive host bearing 105 different genotypes harboured 52% of the total genetic diversity detected within the whole parasite population. Analysis of the genetic data allowed the identification of various ecological, behavioural and immunological factors which are likely to enhance transmission of multiple parasite genotypes towards the vertebrate hosts. From the distribution of repeated identical multilocus genotypes within the parasite population and among the hosts, we have inferred different parameters of the cercarial transmission efficiency as well as patterns and processes by which vertebrate hosts acquire infection in the field. Article in Journal/Newspaper Rattus rattus Cambridge University Press Parasitology 129 5 571 585 |
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Open Polar |
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Cambridge University Press |
op_collection_id |
crcambridgeupr |
language |
English |
topic |
Infectious Diseases Animal Science and Zoology Parasitology |
spellingShingle |
Infectious Diseases Animal Science and Zoology Parasitology THERON, A. SIRE, C. ROGNON, A. PRUGNOLLE, F. DURAND, P. Molecular ecology of Schistosoma mansoni transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts |
topic_facet |
Infectious Diseases Animal Science and Zoology Parasitology |
description |
We investigated the genotypic composition of the digenetic parasite Schistosoma mansoni for its adult stages within the definitive host (the wild rat, Rattus rattus ) and for the larval stages within the intermediate host (the snail, Biomphalaria glabrata ) both collected at the same transmission site. Our analyses are based upon the recognition and distribution of 200 different multilocus genotypes generated by RAPD markers. While intramolluscan larval infrapopulations are characterized by a low infection rate (0·6% on average) and low intra-host genetic diversity (1·1 genotype on average per infected snail), adult infrapopulations within rats showed a high infection rate (94%) and a substantial intra-host genetic diversity (34 genotypes on average) linked to high intensities (160 worms per host on average). A single definitive host bearing 105 different genotypes harboured 52% of the total genetic diversity detected within the whole parasite population. Analysis of the genetic data allowed the identification of various ecological, behavioural and immunological factors which are likely to enhance transmission of multiple parasite genotypes towards the vertebrate hosts. From the distribution of repeated identical multilocus genotypes within the parasite population and among the hosts, we have inferred different parameters of the cercarial transmission efficiency as well as patterns and processes by which vertebrate hosts acquire infection in the field. |
format |
Article in Journal/Newspaper |
author |
THERON, A. SIRE, C. ROGNON, A. PRUGNOLLE, F. DURAND, P. |
author_facet |
THERON, A. SIRE, C. ROGNON, A. PRUGNOLLE, F. DURAND, P. |
author_sort |
THERON, A. |
title |
Molecular ecology of Schistosoma mansoni transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts |
title_short |
Molecular ecology of Schistosoma mansoni transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts |
title_full |
Molecular ecology of Schistosoma mansoni transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts |
title_fullStr |
Molecular ecology of Schistosoma mansoni transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts |
title_full_unstemmed |
Molecular ecology of Schistosoma mansoni transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts |
title_sort |
molecular ecology of schistosoma mansoni transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts |
publisher |
Cambridge University Press (CUP) |
publishDate |
2004 |
url |
http://dx.doi.org/10.1017/s0031182004005943 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0031182004005943 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Parasitology volume 129, issue 5, page 571-585 ISSN 0031-1820 1469-8161 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0031182004005943 |
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Parasitology |
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129 |
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5 |
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571 |
op_container_end_page |
585 |
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1792505312469581824 |