Male genital defect (Dumpton Syndrome) in the dog-whelk Nucella lapillus (Neogastropoda): Mendelian inheritance inferred, based on laboratory breeding experiments

Laboratory breeding of the dog-whelk, Nucella lapillus , has established that the male-sterilizing Dumpton Syndrome (DS)—underdevelopment, or non-development (aphally), of the penis, incomplete formation (non-closure) of the vas deferens, resulting in a split prostate—can be readily observed in male...

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Published in:Journal of the Marine Biological Association of the United Kingdom
Main Author: Gibbs, P.E.
Format: Article in Journal/Newspaper
Language:English
Published: Cambridge University Press (CUP) 2005
Subjects:
Aquatic Science
Cornwall
Dog whelk
Nucella lapillus
Online Access:http://dx.doi.org/10.1017/s0025315405010969h
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0025315405010969
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record_format openpolar
spelling crcambridgeupr:10.1017/s0025315405010969h 2024-03-03T08:49:27+00:00 Male genital defect (Dumpton Syndrome) in the dog-whelk Nucella lapillus (Neogastropoda): Mendelian inheritance inferred, based on laboratory breeding experiments Gibbs, P.E. 2005 http://dx.doi.org/10.1017/s0025315405010969h https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0025315405010969 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms Journal of the Marine Biological Association of the United Kingdom volume 85, issue 1, page 143-150 ISSN 0025-3154 1469-7769 Aquatic Science journal-article 2005 crcambridgeupr https://doi.org/10.1017/s0025315405010969h 2024-02-08T08:46:37Z Laboratory breeding of the dog-whelk, Nucella lapillus , has established that the male-sterilizing Dumpton Syndrome (DS)—underdevelopment, or non-development (aphally), of the penis, incomplete formation (non-closure) of the vas deferens, resulting in a split prostate—can be readily observed in male F1 progeny. Cultivated under high ambient concentrations of the antifouling agent tributyltin (TBT), DS-carrying females can be recognized by their lesser degree of masculinization (imposex): sterilization is thereby avoided. When Dumpton females are crossed, under high ambient TBT, with individuals from a non-DS-affected population (Bude, North Cornwall) DS is absent from both sexes. Crosses of these F1 progeny result in F2 progeny exhibiting the classic DS symptoms in both sexes. A Mendelian mechanism for DS inheritance is suggested by the data. Article in Journal/Newspaper Dog whelk Nucella lapillus Cambridge University Press Cornwall ENVELOPE(-59.688,-59.688,-62.366,-62.366) Journal of the Marine Biological Association of the United Kingdom 85 1 143 150
institution Open Polar
collection Cambridge University Press
op_collection_id crcambridgeupr
language English
topic Aquatic Science
spellingShingle Aquatic Science
Gibbs, P.E.
Male genital defect (Dumpton Syndrome) in the dog-whelk Nucella lapillus (Neogastropoda): Mendelian inheritance inferred, based on laboratory breeding experiments
topic_facet Aquatic Science
description Laboratory breeding of the dog-whelk, Nucella lapillus , has established that the male-sterilizing Dumpton Syndrome (DS)—underdevelopment, or non-development (aphally), of the penis, incomplete formation (non-closure) of the vas deferens, resulting in a split prostate—can be readily observed in male F1 progeny. Cultivated under high ambient concentrations of the antifouling agent tributyltin (TBT), DS-carrying females can be recognized by their lesser degree of masculinization (imposex): sterilization is thereby avoided. When Dumpton females are crossed, under high ambient TBT, with individuals from a non-DS-affected population (Bude, North Cornwall) DS is absent from both sexes. Crosses of these F1 progeny result in F2 progeny exhibiting the classic DS symptoms in both sexes. A Mendelian mechanism for DS inheritance is suggested by the data.
format Article in Journal/Newspaper
author Gibbs, P.E.
author_facet Gibbs, P.E.
author_sort Gibbs, P.E.
title Male genital defect (Dumpton Syndrome) in the dog-whelk Nucella lapillus (Neogastropoda): Mendelian inheritance inferred, based on laboratory breeding experiments
title_short Male genital defect (Dumpton Syndrome) in the dog-whelk Nucella lapillus (Neogastropoda): Mendelian inheritance inferred, based on laboratory breeding experiments
title_full Male genital defect (Dumpton Syndrome) in the dog-whelk Nucella lapillus (Neogastropoda): Mendelian inheritance inferred, based on laboratory breeding experiments
title_fullStr Male genital defect (Dumpton Syndrome) in the dog-whelk Nucella lapillus (Neogastropoda): Mendelian inheritance inferred, based on laboratory breeding experiments
title_full_unstemmed Male genital defect (Dumpton Syndrome) in the dog-whelk Nucella lapillus (Neogastropoda): Mendelian inheritance inferred, based on laboratory breeding experiments
title_sort male genital defect (dumpton syndrome) in the dog-whelk nucella lapillus (neogastropoda): mendelian inheritance inferred, based on laboratory breeding experiments
publisher Cambridge University Press (CUP)
publishDate 2005
url http://dx.doi.org/10.1017/s0025315405010969h
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0025315405010969
long_lat ENVELOPE(-59.688,-59.688,-62.366,-62.366)
geographic Cornwall
geographic_facet Cornwall
genre Dog whelk
Nucella lapillus
genre_facet Dog whelk
Nucella lapillus
op_source Journal of the Marine Biological Association of the United Kingdom
volume 85, issue 1, page 143-150
ISSN 0025-3154 1469-7769
op_rights https://www.cambridge.org/core/terms
op_doi https://doi.org/10.1017/s0025315405010969h
container_title Journal of the Marine Biological Association of the United Kingdom
container_volume 85
container_issue 1
container_start_page 143
op_container_end_page 150
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