Studies of experimental rhinovirus type 2 infections in polar isolation and in England
SUMMARY After five months of total isolation a wintering party of seventeen British Antarctic Survey (BAS) personnel was inoculated under double blind conditions with placebo, or rhinovirus type 2 which had been propagated in tissue culture. The clinical and virological responses of these subjects w...
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Cambridge University Press (CUP)
1976
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crcambridgeupr:10.1017/s0022172400055303 2024-09-15T17:42:22+00:00 Studies of experimental rhinovirus type 2 infections in polar isolation and in England Holmes, M. J. Reed, Sylvia E. Stott, E. J. Tyrrell, D. A. J. 1976 http://dx.doi.org/10.1017/s0022172400055303 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0022172400055303 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms Journal of Hygiene volume 76, issue 3, page 379-393 ISSN 0022-1724 journal-article 1976 crcambridgeupr https://doi.org/10.1017/s0022172400055303 2024-08-07T04:03:28Z SUMMARY After five months of total isolation a wintering party of seventeen British Antarctic Survey (BAS) personnel was inoculated under double blind conditions with placebo, or rhinovirus type 2 which had been propagated in tissue culture. The clinical and virological responses of these subjects were compared with those of volunteers in England who received a similar dose of the same strain. The virus used was apparently partly attenuated for man; at the dosage used its effects in England were similar to a smaller dose of an unattenuated strain, but in the Antarctic it caused relatively severe infections. Both the symptoms and the laboratory evidence of virus infection appeared to be more pronounced in the BAS subjects than in the volunteers in England who received the same challenge. In the former group the infection readily spread to those who were originally given placebo. In the BAS subjects serum antibody titres were well maintained during the isolation period but a significant fall in nasal immunoglobulin concentration was recorded during the 5 months of isolation after the virus challenge. Possible mechanisms for the increased sensitivity to rhinovirus of subjects who have been totally isolated in a small closed community are discussed. Article in Journal/Newspaper Antarc* Antarctic British Antarctic Survey Cambridge University Press Journal of Hygiene 76 3 379 393 |
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Open Polar |
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Cambridge University Press |
op_collection_id |
crcambridgeupr |
language |
English |
description |
SUMMARY After five months of total isolation a wintering party of seventeen British Antarctic Survey (BAS) personnel was inoculated under double blind conditions with placebo, or rhinovirus type 2 which had been propagated in tissue culture. The clinical and virological responses of these subjects were compared with those of volunteers in England who received a similar dose of the same strain. The virus used was apparently partly attenuated for man; at the dosage used its effects in England were similar to a smaller dose of an unattenuated strain, but in the Antarctic it caused relatively severe infections. Both the symptoms and the laboratory evidence of virus infection appeared to be more pronounced in the BAS subjects than in the volunteers in England who received the same challenge. In the former group the infection readily spread to those who were originally given placebo. In the BAS subjects serum antibody titres were well maintained during the isolation period but a significant fall in nasal immunoglobulin concentration was recorded during the 5 months of isolation after the virus challenge. Possible mechanisms for the increased sensitivity to rhinovirus of subjects who have been totally isolated in a small closed community are discussed. |
format |
Article in Journal/Newspaper |
author |
Holmes, M. J. Reed, Sylvia E. Stott, E. J. Tyrrell, D. A. J. |
spellingShingle |
Holmes, M. J. Reed, Sylvia E. Stott, E. J. Tyrrell, D. A. J. Studies of experimental rhinovirus type 2 infections in polar isolation and in England |
author_facet |
Holmes, M. J. Reed, Sylvia E. Stott, E. J. Tyrrell, D. A. J. |
author_sort |
Holmes, M. J. |
title |
Studies of experimental rhinovirus type 2 infections in polar isolation and in England |
title_short |
Studies of experimental rhinovirus type 2 infections in polar isolation and in England |
title_full |
Studies of experimental rhinovirus type 2 infections in polar isolation and in England |
title_fullStr |
Studies of experimental rhinovirus type 2 infections in polar isolation and in England |
title_full_unstemmed |
Studies of experimental rhinovirus type 2 infections in polar isolation and in England |
title_sort |
studies of experimental rhinovirus type 2 infections in polar isolation and in england |
publisher |
Cambridge University Press (CUP) |
publishDate |
1976 |
url |
http://dx.doi.org/10.1017/s0022172400055303 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0022172400055303 |
genre |
Antarc* Antarctic British Antarctic Survey |
genre_facet |
Antarc* Antarctic British Antarctic Survey |
op_source |
Journal of Hygiene volume 76, issue 3, page 379-393 ISSN 0022-1724 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0022172400055303 |
container_title |
Journal of Hygiene |
container_volume |
76 |
container_issue |
3 |
container_start_page |
379 |
op_container_end_page |
393 |
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1810488915336888320 |