Endogenous production of n -3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α -linolenic:linoleic ratio in Atlantic salmon ( Salmo salar )
Abstract Atlantic salmon ( Salmo salar ) possess enzymes required for the endogenous biosynthesis of n -3 long-chain PUFA (LC-PUFA), EPA and DHA, from α -linolenic acid (ALA). Linoleic acid (LA) competes with ALA for LC-PUFA biosynthesis enzymes leading to the production of n -6 LC-PUFA, including a...
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2019
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Online Access: | http://dx.doi.org/10.1017/s0007114519001946 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114519001946 |
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crcambridgeupr:10.1017/s0007114519001946 2024-05-12T08:01:19+00:00 Endogenous production of n -3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α -linolenic:linoleic ratio in Atlantic salmon ( Salmo salar ) Sprague, Matthew Xu, Gong Betancor, Monica B. Olsen, Rolf E. Torrissen, Ole Glencross, Brett D. Tocher, Douglas R. 2019 http://dx.doi.org/10.1017/s0007114519001946 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114519001946 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 122, issue 10, page 1091-1102 ISSN 0007-1145 1475-2662 Nutrition and Dietetics Medicine (miscellaneous) journal-article 2019 crcambridgeupr https://doi.org/10.1017/s0007114519001946 2024-04-18T06:54:07Z Abstract Atlantic salmon ( Salmo salar ) possess enzymes required for the endogenous biosynthesis of n -3 long-chain PUFA (LC-PUFA), EPA and DHA, from α -linolenic acid (ALA). Linoleic acid (LA) competes with ALA for LC-PUFA biosynthesis enzymes leading to the production of n -6 LC-PUFA, including arachidonic acid (ARA). We aimed to quantify the endogenous production of EPA and DHA from ALA in salmon fed from first feeding on diets that contain no EPA and DHA and to determine the influence of dietary LA and ALA:LA ratio on LC-PUFA production. Salmon were fed from first feeding for 22 weeks with three diets formulated with linseed and sunflower oils to provide ALA:LA ratios of approximately 3:1, 1:1 and 1:3. Endogenous production of n -3 LC-PUFA was 5·9, 4·4 and 2·8 mg per g fish and that of n -6 LC-PUFA was 0·2, 0·5 and 1·4 mg per g fish in salmon fed diets with ALA:LA ratios of 3:1, 1:1 and 1:3, respectively. The ratio of n -3: n -6 LC-PUFA production decreased from 27·4 to 2·0, and DHA:EPA ratio increased and EPA:ARA and DHA:ARA ratios decreased, as dietary ALA:LA ratio decreased. In conclusion, with a dietary ALA:LA ratio of 1, salmon fry/parr produced about 28 μg n -3 LC-PUFA per g fish per d, with a DHA:EPA ratio of 3·4. Production of n -3 LC-PUFA exceeded that of n -6 LC-PUFA by almost 9-fold. Reducing the dietary ALA:LA ratio reduced n -3 LC-PUFA production and EPA:ARA and DHA:ARA ratios but increased n -6 LC-PUFA production and DHA:EPA ratio. Article in Journal/Newspaper Atlantic salmon Salmo salar Cambridge University Press British Journal of Nutrition 122 10 1091 1102 |
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Open Polar |
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Cambridge University Press |
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crcambridgeupr |
language |
English |
topic |
Nutrition and Dietetics Medicine (miscellaneous) |
spellingShingle |
Nutrition and Dietetics Medicine (miscellaneous) Sprague, Matthew Xu, Gong Betancor, Monica B. Olsen, Rolf E. Torrissen, Ole Glencross, Brett D. Tocher, Douglas R. Endogenous production of n -3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α -linolenic:linoleic ratio in Atlantic salmon ( Salmo salar ) |
topic_facet |
Nutrition and Dietetics Medicine (miscellaneous) |
description |
Abstract Atlantic salmon ( Salmo salar ) possess enzymes required for the endogenous biosynthesis of n -3 long-chain PUFA (LC-PUFA), EPA and DHA, from α -linolenic acid (ALA). Linoleic acid (LA) competes with ALA for LC-PUFA biosynthesis enzymes leading to the production of n -6 LC-PUFA, including arachidonic acid (ARA). We aimed to quantify the endogenous production of EPA and DHA from ALA in salmon fed from first feeding on diets that contain no EPA and DHA and to determine the influence of dietary LA and ALA:LA ratio on LC-PUFA production. Salmon were fed from first feeding for 22 weeks with three diets formulated with linseed and sunflower oils to provide ALA:LA ratios of approximately 3:1, 1:1 and 1:3. Endogenous production of n -3 LC-PUFA was 5·9, 4·4 and 2·8 mg per g fish and that of n -6 LC-PUFA was 0·2, 0·5 and 1·4 mg per g fish in salmon fed diets with ALA:LA ratios of 3:1, 1:1 and 1:3, respectively. The ratio of n -3: n -6 LC-PUFA production decreased from 27·4 to 2·0, and DHA:EPA ratio increased and EPA:ARA and DHA:ARA ratios decreased, as dietary ALA:LA ratio decreased. In conclusion, with a dietary ALA:LA ratio of 1, salmon fry/parr produced about 28 μg n -3 LC-PUFA per g fish per d, with a DHA:EPA ratio of 3·4. Production of n -3 LC-PUFA exceeded that of n -6 LC-PUFA by almost 9-fold. Reducing the dietary ALA:LA ratio reduced n -3 LC-PUFA production and EPA:ARA and DHA:ARA ratios but increased n -6 LC-PUFA production and DHA:EPA ratio. |
format |
Article in Journal/Newspaper |
author |
Sprague, Matthew Xu, Gong Betancor, Monica B. Olsen, Rolf E. Torrissen, Ole Glencross, Brett D. Tocher, Douglas R. |
author_facet |
Sprague, Matthew Xu, Gong Betancor, Monica B. Olsen, Rolf E. Torrissen, Ole Glencross, Brett D. Tocher, Douglas R. |
author_sort |
Sprague, Matthew |
title |
Endogenous production of n -3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α -linolenic:linoleic ratio in Atlantic salmon ( Salmo salar ) |
title_short |
Endogenous production of n -3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α -linolenic:linoleic ratio in Atlantic salmon ( Salmo salar ) |
title_full |
Endogenous production of n -3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α -linolenic:linoleic ratio in Atlantic salmon ( Salmo salar ) |
title_fullStr |
Endogenous production of n -3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α -linolenic:linoleic ratio in Atlantic salmon ( Salmo salar ) |
title_full_unstemmed |
Endogenous production of n -3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α -linolenic:linoleic ratio in Atlantic salmon ( Salmo salar ) |
title_sort |
endogenous production of n -3 long-chain pufa from first feeding and the influence of dietary linoleic acid and the α -linolenic:linoleic ratio in atlantic salmon ( salmo salar ) |
publisher |
Cambridge University Press (CUP) |
publishDate |
2019 |
url |
http://dx.doi.org/10.1017/s0007114519001946 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114519001946 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
British Journal of Nutrition volume 122, issue 10, page 1091-1102 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0007114519001946 |
container_title |
British Journal of Nutrition |
container_volume |
122 |
container_issue |
10 |
container_start_page |
1091 |
op_container_end_page |
1102 |
_version_ |
1798843441326587904 |