Tissue sterol composition in Atlantic salmon ( Salmo salar L.) depends on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content
Abstract The aim of the study was to investigate how the dietary sterol composition, including cholesterol, phytosterol:cholesterol ratio and phytosterols, affect the absorption, biliary excretion, retention, tissue storage and distribution of cholesterol and individual phytosterols in Atlantic salm...
Published in: | British Journal of Nutrition |
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Language: | English |
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Cambridge University Press (CUP)
2018
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Online Access: | http://dx.doi.org/10.1017/s0007114517003853 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114517003853 |
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crcambridgeupr:10.1017/s0007114517003853 2024-09-09T19:30:25+00:00 Tissue sterol composition in Atlantic salmon ( Salmo salar L.) depends on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content Sissener, Nini H. Rosenlund, Grethe Stubhaug, Ingunn Liland, Nina S. 2018 http://dx.doi.org/10.1017/s0007114517003853 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114517003853 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 119, issue 6, page 599-609 ISSN 0007-1145 1475-2662 journal-article 2018 crcambridgeupr https://doi.org/10.1017/s0007114517003853 2024-06-26T04:04:16Z Abstract The aim of the study was to investigate how the dietary sterol composition, including cholesterol, phytosterol:cholesterol ratio and phytosterols, affect the absorption, biliary excretion, retention, tissue storage and distribution of cholesterol and individual phytosterols in Atlantic salmon ( Salmo salar L.). A feeding trial was conducted at two different temperatures (6 and 12°C), using nine different diets with varying contents of phytosterols, cholesterol and phytosterol:cholesterol ratio. Cholesterol retention values were clearly dependent on dietary cholesterol, and showed that fish fed cholesterol levels <1000 mg/kg feed produced considerable quantities of cholesterol de novo . Despite this production, cholesterol content increased with increasing dietary cholesterol in liver, plasma, bile, muscle, adipose tissue and whole fish at 12°C, and in plasma, bile and whole fish at 6°C. The tissue sterol composition generally depended on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content in itself. Campesterol and brassicasterol appeared to be the phytosterols with the highest intestinal absorption in Atlantic salmon. There was a high biliary excretion of campesterol, but not of brassicasterol, which accumulated in tissues and particularly in adipose tissue, with 2-fold-higher retention at 12°C compared with 6°C. Campesterol had the second highest retention of the phytosterols in the fish, but with no difference between the two temperatures. Other phytosterols had very low retention. Although brassicasterol retention decreased with increasing dietary phytosterols, campesterol retention decreased with increasing dietary cholesterol, indicating differences in the uptake mechanisms for these two sterols. Article in Journal/Newspaper Atlantic salmon Salmo salar Cambridge University Press British Journal of Nutrition 119 6 599 609 |
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Open Polar |
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Cambridge University Press |
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crcambridgeupr |
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English |
description |
Abstract The aim of the study was to investigate how the dietary sterol composition, including cholesterol, phytosterol:cholesterol ratio and phytosterols, affect the absorption, biliary excretion, retention, tissue storage and distribution of cholesterol and individual phytosterols in Atlantic salmon ( Salmo salar L.). A feeding trial was conducted at two different temperatures (6 and 12°C), using nine different diets with varying contents of phytosterols, cholesterol and phytosterol:cholesterol ratio. Cholesterol retention values were clearly dependent on dietary cholesterol, and showed that fish fed cholesterol levels <1000 mg/kg feed produced considerable quantities of cholesterol de novo . Despite this production, cholesterol content increased with increasing dietary cholesterol in liver, plasma, bile, muscle, adipose tissue and whole fish at 12°C, and in plasma, bile and whole fish at 6°C. The tissue sterol composition generally depended on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content in itself. Campesterol and brassicasterol appeared to be the phytosterols with the highest intestinal absorption in Atlantic salmon. There was a high biliary excretion of campesterol, but not of brassicasterol, which accumulated in tissues and particularly in adipose tissue, with 2-fold-higher retention at 12°C compared with 6°C. Campesterol had the second highest retention of the phytosterols in the fish, but with no difference between the two temperatures. Other phytosterols had very low retention. Although brassicasterol retention decreased with increasing dietary phytosterols, campesterol retention decreased with increasing dietary cholesterol, indicating differences in the uptake mechanisms for these two sterols. |
format |
Article in Journal/Newspaper |
author |
Sissener, Nini H. Rosenlund, Grethe Stubhaug, Ingunn Liland, Nina S. |
spellingShingle |
Sissener, Nini H. Rosenlund, Grethe Stubhaug, Ingunn Liland, Nina S. Tissue sterol composition in Atlantic salmon ( Salmo salar L.) depends on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content |
author_facet |
Sissener, Nini H. Rosenlund, Grethe Stubhaug, Ingunn Liland, Nina S. |
author_sort |
Sissener, Nini H. |
title |
Tissue sterol composition in Atlantic salmon ( Salmo salar L.) depends on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content |
title_short |
Tissue sterol composition in Atlantic salmon ( Salmo salar L.) depends on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content |
title_full |
Tissue sterol composition in Atlantic salmon ( Salmo salar L.) depends on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content |
title_fullStr |
Tissue sterol composition in Atlantic salmon ( Salmo salar L.) depends on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content |
title_full_unstemmed |
Tissue sterol composition in Atlantic salmon ( Salmo salar L.) depends on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content |
title_sort |
tissue sterol composition in atlantic salmon ( salmo salar l.) depends on the dietary cholesterol content and on the dietary phytosterol:cholesterol ratio, but not on the dietary phytosterol content |
publisher |
Cambridge University Press (CUP) |
publishDate |
2018 |
url |
http://dx.doi.org/10.1017/s0007114517003853 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114517003853 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
British Journal of Nutrition volume 119, issue 6, page 599-609 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0007114517003853 |
container_title |
British Journal of Nutrition |
container_volume |
119 |
container_issue |
6 |
container_start_page |
599 |
op_container_end_page |
609 |
_version_ |
1809899394377449472 |