Dietaryl-tryptophan leaves a lasting impression on the brain and the stress response
Abstract Comparative models suggest that effects of dietary tryptophan (Trp) on brain serotonin (5-hydroxytryptamine; 5-HT) neurochemistry and stress responsiveness are present throughout the vertebrate lineage. Moreover, hypothalamic 5-HT seems to play a central role in control of the neuroendocrin...
Published in: | British Journal of Nutrition |
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Language: | English |
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Cambridge University Press (CUP)
2017
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Online Access: | http://dx.doi.org/10.1017/s0007114517001428 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114517001428 |
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crcambridgeupr:10.1017/s0007114517001428 2024-09-15T17:56:30+00:00 Dietaryl-tryptophan leaves a lasting impression on the brain and the stress response Höglund, Erik Øverli, Øyvind Andersson, Madelene Å. Silva, Patricia Laursen, Danielle Caroline Moltesen, Maria M. Krogdahl, Åshild Schjolden, Joachim Winberg, Svante Vindas, Marco A. Mayer, Ian Hillestad, Marie 2017 http://dx.doi.org/10.1017/s0007114517001428 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114517001428 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 117, issue 10, page 1351-1357 ISSN 0007-1145 1475-2662 journal-article 2017 crcambridgeupr https://doi.org/10.1017/s0007114517001428 2024-06-26T04:04:20Z Abstract Comparative models suggest that effects of dietary tryptophan (Trp) on brain serotonin (5-hydroxytryptamine; 5-HT) neurochemistry and stress responsiveness are present throughout the vertebrate lineage. Moreover, hypothalamic 5-HT seems to play a central role in control of the neuroendocrine stress axis in all vertebrates. Still, recent fish studies suggest long-term effects of dietary Trp on stress responsiveness, which are independent of hypothalamic 5-HT. Here, we investigated if dietary Trp treatment may result in long-lasting effects on stress responsiveness, including changes in plasma cortisol levels and 5-HT neurochemistry in the telencephalon and hypothalamus of Atlantic salmon. Fish were fed diets containing one, two or three times the Trp content in normal feed for 1 week. Subsequently, fish were reintroduced to control feed and were exposed to acute crowding stress for 1 h, 8 and 21 d post Trp treatment. Generally, acute crowding resulted in lower plasma cortisol levels in fish treated with 3×Trp compared with 1×Trp- and 2×Trp-treated fish. The same general pattern was reflected in telencephalic 5-HTergic turnover, for which 3×Trp-treated fish showed decreased values compared with 2×Trp-treated fish. These long-term effects on post-stress plasma cortisol levels and concomitant 5-HT turnover in the telencephalon lends further support to the fact that the extrahypothalamic control of the neuroendocrine stress response is conserved within the vertebrate lineage. Moreover, they indicate that trophic/structural effects in the brain underlie the effects of dietary Trp treatment on stress reactivity. Article in Journal/Newspaper Atlantic salmon Cambridge University Press British Journal of Nutrition 117 10 1351 1357 |
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Open Polar |
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Cambridge University Press |
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crcambridgeupr |
language |
English |
description |
Abstract Comparative models suggest that effects of dietary tryptophan (Trp) on brain serotonin (5-hydroxytryptamine; 5-HT) neurochemistry and stress responsiveness are present throughout the vertebrate lineage. Moreover, hypothalamic 5-HT seems to play a central role in control of the neuroendocrine stress axis in all vertebrates. Still, recent fish studies suggest long-term effects of dietary Trp on stress responsiveness, which are independent of hypothalamic 5-HT. Here, we investigated if dietary Trp treatment may result in long-lasting effects on stress responsiveness, including changes in plasma cortisol levels and 5-HT neurochemistry in the telencephalon and hypothalamus of Atlantic salmon. Fish were fed diets containing one, two or three times the Trp content in normal feed for 1 week. Subsequently, fish were reintroduced to control feed and were exposed to acute crowding stress for 1 h, 8 and 21 d post Trp treatment. Generally, acute crowding resulted in lower plasma cortisol levels in fish treated with 3×Trp compared with 1×Trp- and 2×Trp-treated fish. The same general pattern was reflected in telencephalic 5-HTergic turnover, for which 3×Trp-treated fish showed decreased values compared with 2×Trp-treated fish. These long-term effects on post-stress plasma cortisol levels and concomitant 5-HT turnover in the telencephalon lends further support to the fact that the extrahypothalamic control of the neuroendocrine stress response is conserved within the vertebrate lineage. Moreover, they indicate that trophic/structural effects in the brain underlie the effects of dietary Trp treatment on stress reactivity. |
format |
Article in Journal/Newspaper |
author |
Höglund, Erik Øverli, Øyvind Andersson, Madelene Å. Silva, Patricia Laursen, Danielle Caroline Moltesen, Maria M. Krogdahl, Åshild Schjolden, Joachim Winberg, Svante Vindas, Marco A. Mayer, Ian Hillestad, Marie |
spellingShingle |
Höglund, Erik Øverli, Øyvind Andersson, Madelene Å. Silva, Patricia Laursen, Danielle Caroline Moltesen, Maria M. Krogdahl, Åshild Schjolden, Joachim Winberg, Svante Vindas, Marco A. Mayer, Ian Hillestad, Marie Dietaryl-tryptophan leaves a lasting impression on the brain and the stress response |
author_facet |
Höglund, Erik Øverli, Øyvind Andersson, Madelene Å. Silva, Patricia Laursen, Danielle Caroline Moltesen, Maria M. Krogdahl, Åshild Schjolden, Joachim Winberg, Svante Vindas, Marco A. Mayer, Ian Hillestad, Marie |
author_sort |
Höglund, Erik |
title |
Dietaryl-tryptophan leaves a lasting impression on the brain and the stress response |
title_short |
Dietaryl-tryptophan leaves a lasting impression on the brain and the stress response |
title_full |
Dietaryl-tryptophan leaves a lasting impression on the brain and the stress response |
title_fullStr |
Dietaryl-tryptophan leaves a lasting impression on the brain and the stress response |
title_full_unstemmed |
Dietaryl-tryptophan leaves a lasting impression on the brain and the stress response |
title_sort |
dietaryl-tryptophan leaves a lasting impression on the brain and the stress response |
publisher |
Cambridge University Press (CUP) |
publishDate |
2017 |
url |
http://dx.doi.org/10.1017/s0007114517001428 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114517001428 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
British Journal of Nutrition volume 117, issue 10, page 1351-1357 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0007114517001428 |
container_title |
British Journal of Nutrition |
container_volume |
117 |
container_issue |
10 |
container_start_page |
1351 |
op_container_end_page |
1357 |
_version_ |
1810432699689598976 |