Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status
Abstract The occurrence of thyroid disorders relies on I nutrition and monitoring of all populations is recommended. Measuring I in urine is standard but thyroglobulin in serum is an alternative. This led us to assess the reliability of studies using serum thyroglobulin compared with urinary I to as...
Published in: | British Journal of Nutrition |
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Cambridge University Press (CUP)
2017
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Online Access: | http://dx.doi.org/10.1017/s0007114517000162 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114517000162 |
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crcambridgeupr:10.1017/s0007114517000162 2024-03-03T08:45:03+00:00 Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status Andersen, Stig Noahsen, Paneeraq Westergaard, Louise Laurberg, Peter 2017 http://dx.doi.org/10.1017/s0007114517000162 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114517000162 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 117, issue 3, page 441-449 ISSN 0007-1145 1475-2662 Nutrition and Dietetics Medicine (miscellaneous) journal-article 2017 crcambridgeupr https://doi.org/10.1017/s0007114517000162 2024-02-08T08:41:11Z Abstract The occurrence of thyroid disorders relies on I nutrition and monitoring of all populations is recommended. Measuring I in urine is standard but thyroglobulin in serum is an alternative. This led us to assess the reliability of studies using serum thyroglobulin compared with urinary I to assess the I nutrition level and calculate the number of participants needed in a study with repeated data sampling in the same individuals for 1 year. Diet, supplement use and life style factors were assessed by questionnaires. We measured thyroglobulin and thyroglobulin antibodies in serum and I in urine. Participants were thirty-three Caucasians and sixty-four Inuit living in Greenland aged 30–49 years. Serum thyroglobulin decreased with rising I excretion (Kendall’s τ −0·29, P =0·005) and did not differ with ethnicity. Variation in individuals was lower for serum-thyroglobulin than for urinary I (mean individual CV: 15·1 v . 46·1 %; P <0·01). It required 245 urine samples to be 95 % certain of having a urinary I excretion within 10 % of the true mean of the population. For serum-thyroglobulin the same precision required 206 samples. In an individual ten times more samples were needed to depict I deficiency when using urinary I excretion compared with serum-thyroglobulin. In conclusion, more participants are need to portray I deficiency in a population when using urinary I compared with serum-thyroglobulin, and about ten times more samples are needed in an individual. Adding serum-thyroglobulin to urinary I may inform surveys of I nutrition by allowing subgroup analysis with similar reliability. Article in Journal/Newspaper Greenland inuit Cambridge University Press Greenland British Journal of Nutrition 117 3 441 449 |
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English |
topic |
Nutrition and Dietetics Medicine (miscellaneous) |
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Nutrition and Dietetics Medicine (miscellaneous) Andersen, Stig Noahsen, Paneeraq Westergaard, Louise Laurberg, Peter Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status |
topic_facet |
Nutrition and Dietetics Medicine (miscellaneous) |
description |
Abstract The occurrence of thyroid disorders relies on I nutrition and monitoring of all populations is recommended. Measuring I in urine is standard but thyroglobulin in serum is an alternative. This led us to assess the reliability of studies using serum thyroglobulin compared with urinary I to assess the I nutrition level and calculate the number of participants needed in a study with repeated data sampling in the same individuals for 1 year. Diet, supplement use and life style factors were assessed by questionnaires. We measured thyroglobulin and thyroglobulin antibodies in serum and I in urine. Participants were thirty-three Caucasians and sixty-four Inuit living in Greenland aged 30–49 years. Serum thyroglobulin decreased with rising I excretion (Kendall’s τ −0·29, P =0·005) and did not differ with ethnicity. Variation in individuals was lower for serum-thyroglobulin than for urinary I (mean individual CV: 15·1 v . 46·1 %; P <0·01). It required 245 urine samples to be 95 % certain of having a urinary I excretion within 10 % of the true mean of the population. For serum-thyroglobulin the same precision required 206 samples. In an individual ten times more samples were needed to depict I deficiency when using urinary I excretion compared with serum-thyroglobulin. In conclusion, more participants are need to portray I deficiency in a population when using urinary I compared with serum-thyroglobulin, and about ten times more samples are needed in an individual. Adding serum-thyroglobulin to urinary I may inform surveys of I nutrition by allowing subgroup analysis with similar reliability. |
format |
Article in Journal/Newspaper |
author |
Andersen, Stig Noahsen, Paneeraq Westergaard, Louise Laurberg, Peter |
author_facet |
Andersen, Stig Noahsen, Paneeraq Westergaard, Louise Laurberg, Peter |
author_sort |
Andersen, Stig |
title |
Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status |
title_short |
Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status |
title_full |
Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status |
title_fullStr |
Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status |
title_full_unstemmed |
Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status |
title_sort |
reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status |
publisher |
Cambridge University Press (CUP) |
publishDate |
2017 |
url |
http://dx.doi.org/10.1017/s0007114517000162 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114517000162 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_source |
British Journal of Nutrition volume 117, issue 3, page 441-449 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0007114517000162 |
container_title |
British Journal of Nutrition |
container_volume |
117 |
container_issue |
3 |
container_start_page |
441 |
op_container_end_page |
449 |
_version_ |
1792500567431446528 |