Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation withl-tryptophan in Atlantic cod ( Gadus morhua)
The brain monoamines serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) both play an integrative role in behavioural and neuroendocrine responses to challenges, and comparative models suggest common mechanisms for dietary modulation of transmission by these signal substances in vertebrates. Pre...
Published in: | British Journal of Nutrition |
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Cambridge University Press (CUP)
2012
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Online Access: | http://dx.doi.org/10.1017/s0007114512004345 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114512004345 |
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crcambridgeupr:10.1017/s0007114512004345 2024-09-15T17:55:27+00:00 Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation withl-tryptophan in Atlantic cod ( Gadus morhua) Basic, Dean Schjolden, Joachim Krogdahl, Åshild von Krogh, Kristine Hillestad, Marie Winberg, Svante Mayer, Ian Skjerve, Eystein Höglund, Erik 2012 http://dx.doi.org/10.1017/s0007114512004345 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114512004345 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 109, issue 12, page 2166-2174 ISSN 0007-1145 1475-2662 journal-article 2012 crcambridgeupr https://doi.org/10.1017/s0007114512004345 2024-07-31T04:04:23Z The brain monoamines serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) both play an integrative role in behavioural and neuroendocrine responses to challenges, and comparative models suggest common mechanisms for dietary modulation of transmission by these signal substances in vertebrates. Previous studies in teleosts demonstrate that 7 d of dietary administration with l -tryptophan (Trp), the direct precursor of 5-HT, suppresses the endocrine stress response. The present study investigated how long the suppressive effects of a Trp-enriched feed regimen, at doses corresponding to two, three or four times the Trp levels in commercial feed, last in juvenile Atlantic cod ( Gadus morhua ) when the fish are reintroduced to a diet with standard amino acid composition. We also wanted to determine whether Trp supplementation induced changes in brain monoaminergic neurochemistry in those forebrain structures innervated by DA- and 5-HTergic neurons, by measuring regional activity of DA and 5-HT in the lateral pallial regions (Dl) of the telencephalon and nucleus lateralis tuberis (NLT) of the hypothalamus. Dietary Trp resulted in a dose-dependent suppression in plasma cortisol among fish exposed to confinement stress on the first day following experimental diet; however, such an effect was not observed at 2 or 6 d after Trp treatment. Feeding the fish with moderate Trp doses also evoked a general increase in DA and 5-HT-ergic activity, suggesting that these neural circuits within the NLT and Dl may be indirectly involved in regulating the acute stress response. Article in Journal/Newspaper atlantic cod Gadus morhua Cambridge University Press British Journal of Nutrition 109 12 2166 2174 |
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Open Polar |
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Cambridge University Press |
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crcambridgeupr |
language |
English |
description |
The brain monoamines serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) both play an integrative role in behavioural and neuroendocrine responses to challenges, and comparative models suggest common mechanisms for dietary modulation of transmission by these signal substances in vertebrates. Previous studies in teleosts demonstrate that 7 d of dietary administration with l -tryptophan (Trp), the direct precursor of 5-HT, suppresses the endocrine stress response. The present study investigated how long the suppressive effects of a Trp-enriched feed regimen, at doses corresponding to two, three or four times the Trp levels in commercial feed, last in juvenile Atlantic cod ( Gadus morhua ) when the fish are reintroduced to a diet with standard amino acid composition. We also wanted to determine whether Trp supplementation induced changes in brain monoaminergic neurochemistry in those forebrain structures innervated by DA- and 5-HTergic neurons, by measuring regional activity of DA and 5-HT in the lateral pallial regions (Dl) of the telencephalon and nucleus lateralis tuberis (NLT) of the hypothalamus. Dietary Trp resulted in a dose-dependent suppression in plasma cortisol among fish exposed to confinement stress on the first day following experimental diet; however, such an effect was not observed at 2 or 6 d after Trp treatment. Feeding the fish with moderate Trp doses also evoked a general increase in DA and 5-HT-ergic activity, suggesting that these neural circuits within the NLT and Dl may be indirectly involved in regulating the acute stress response. |
format |
Article in Journal/Newspaper |
author |
Basic, Dean Schjolden, Joachim Krogdahl, Åshild von Krogh, Kristine Hillestad, Marie Winberg, Svante Mayer, Ian Skjerve, Eystein Höglund, Erik |
spellingShingle |
Basic, Dean Schjolden, Joachim Krogdahl, Åshild von Krogh, Kristine Hillestad, Marie Winberg, Svante Mayer, Ian Skjerve, Eystein Höglund, Erik Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation withl-tryptophan in Atlantic cod ( Gadus morhua) |
author_facet |
Basic, Dean Schjolden, Joachim Krogdahl, Åshild von Krogh, Kristine Hillestad, Marie Winberg, Svante Mayer, Ian Skjerve, Eystein Höglund, Erik |
author_sort |
Basic, Dean |
title |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation withl-tryptophan in Atlantic cod ( Gadus morhua) |
title_short |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation withl-tryptophan in Atlantic cod ( Gadus morhua) |
title_full |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation withl-tryptophan in Atlantic cod ( Gadus morhua) |
title_fullStr |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation withl-tryptophan in Atlantic cod ( Gadus morhua) |
title_full_unstemmed |
Changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation withl-tryptophan in Atlantic cod ( Gadus morhua) |
title_sort |
changes in regional brain monoaminergic activity and temporary down-regulation in stress response from dietary supplementation withl-tryptophan in atlantic cod ( gadus morhua) |
publisher |
Cambridge University Press (CUP) |
publishDate |
2012 |
url |
http://dx.doi.org/10.1017/s0007114512004345 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114512004345 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
British Journal of Nutrition volume 109, issue 12, page 2166-2174 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0007114512004345 |
container_title |
British Journal of Nutrition |
container_volume |
109 |
container_issue |
12 |
container_start_page |
2166 |
op_container_end_page |
2174 |
_version_ |
1810431743293915136 |