Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon ( Salmo salar L.) and mice, and induces weight gain and inflammation in mice
Dietary intake of linoleic acid (LA) has increased dramatically during the twentieth century and is associated with a greater prevalence of obesity. Vegetable oils are recognised as suitable alternatives to fish oil (FO) in feed for Atlantic salmon ( Salmo salar L.) but introduce high amounts of LA...
Published in: | British Journal of Nutrition |
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Language: | English |
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Cambridge University Press (CUP)
2012
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Online Access: | http://dx.doi.org/10.1017/s0007114512003364 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114512003364 |
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crcambridgeupr:10.1017/s0007114512003364 2024-09-15T17:55:48+00:00 Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon ( Salmo salar L.) and mice, and induces weight gain and inflammation in mice Alvheim, Anita R. Torstensen, Bente E. Lin, Yu Hong Lillefosse, Haldis H. Lock, Erik-Jan Madsen, Lise Hibbeln, Joseph R. Malde, Marian K. 2012 http://dx.doi.org/10.1017/s0007114512003364 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114512003364 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 109, issue 8, page 1508-1517 ISSN 0007-1145 1475-2662 journal-article 2012 crcambridgeupr https://doi.org/10.1017/s0007114512003364 2024-08-07T04:02:36Z Dietary intake of linoleic acid (LA) has increased dramatically during the twentieth century and is associated with a greater prevalence of obesity. Vegetable oils are recognised as suitable alternatives to fish oil (FO) in feed for Atlantic salmon ( Salmo salar L.) but introduce high amounts of LA in the salmon fillet. The effect on fish consumers of such a replacement remains to be elucidated. Here, we investigate the effect of excessive dietary LA from soyabean oil (SO) on endocannabinoid levels in Atlantic salmon and mice, and study the metabolic effects in mice when SO replaces FO in feed for Atlantic salmon. Atlantic salmon were fed FO and SO for 6 months, and the salmon fillet was used to produce feed for mice. Male C57BL/6J mice were fed diets of 35 % of energy as fat based on FO- and SO-enriched salmon for 16 weeks. We found that replacing FO with SO in feed for Atlantic salmon increased LA, arachidonic acid (AA), decreased EPA and DHA, elevated the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), and increased TAG accumulation in the salmon liver. In mice, the SO salmon diet increased LA and AA and decreased EPA and DHA in the liver and erythrocyte phospholipids, and elevated 2-AG and AEA associated with increased feed efficiency, weight gain and adipose tissue inflammation compared with mice fed the FO salmon diet. In conclusion, excessive dietary LA elevates endocannabinoids in the liver of salmon and mice, and increases weight gain and counteracts the anti-inflammatory properties of EPA and DHA in mice. Article in Journal/Newspaper Atlantic salmon Salmo salar Cambridge University Press British Journal of Nutrition 109 8 1508 1517 |
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Open Polar |
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Cambridge University Press |
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crcambridgeupr |
language |
English |
description |
Dietary intake of linoleic acid (LA) has increased dramatically during the twentieth century and is associated with a greater prevalence of obesity. Vegetable oils are recognised as suitable alternatives to fish oil (FO) in feed for Atlantic salmon ( Salmo salar L.) but introduce high amounts of LA in the salmon fillet. The effect on fish consumers of such a replacement remains to be elucidated. Here, we investigate the effect of excessive dietary LA from soyabean oil (SO) on endocannabinoid levels in Atlantic salmon and mice, and study the metabolic effects in mice when SO replaces FO in feed for Atlantic salmon. Atlantic salmon were fed FO and SO for 6 months, and the salmon fillet was used to produce feed for mice. Male C57BL/6J mice were fed diets of 35 % of energy as fat based on FO- and SO-enriched salmon for 16 weeks. We found that replacing FO with SO in feed for Atlantic salmon increased LA, arachidonic acid (AA), decreased EPA and DHA, elevated the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), and increased TAG accumulation in the salmon liver. In mice, the SO salmon diet increased LA and AA and decreased EPA and DHA in the liver and erythrocyte phospholipids, and elevated 2-AG and AEA associated with increased feed efficiency, weight gain and adipose tissue inflammation compared with mice fed the FO salmon diet. In conclusion, excessive dietary LA elevates endocannabinoids in the liver of salmon and mice, and increases weight gain and counteracts the anti-inflammatory properties of EPA and DHA in mice. |
format |
Article in Journal/Newspaper |
author |
Alvheim, Anita R. Torstensen, Bente E. Lin, Yu Hong Lillefosse, Haldis H. Lock, Erik-Jan Madsen, Lise Hibbeln, Joseph R. Malde, Marian K. |
spellingShingle |
Alvheim, Anita R. Torstensen, Bente E. Lin, Yu Hong Lillefosse, Haldis H. Lock, Erik-Jan Madsen, Lise Hibbeln, Joseph R. Malde, Marian K. Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon ( Salmo salar L.) and mice, and induces weight gain and inflammation in mice |
author_facet |
Alvheim, Anita R. Torstensen, Bente E. Lin, Yu Hong Lillefosse, Haldis H. Lock, Erik-Jan Madsen, Lise Hibbeln, Joseph R. Malde, Marian K. |
author_sort |
Alvheim, Anita R. |
title |
Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon ( Salmo salar L.) and mice, and induces weight gain and inflammation in mice |
title_short |
Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon ( Salmo salar L.) and mice, and induces weight gain and inflammation in mice |
title_full |
Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon ( Salmo salar L.) and mice, and induces weight gain and inflammation in mice |
title_fullStr |
Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon ( Salmo salar L.) and mice, and induces weight gain and inflammation in mice |
title_full_unstemmed |
Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon ( Salmo salar L.) and mice, and induces weight gain and inflammation in mice |
title_sort |
dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in atlantic salmon ( salmo salar l.) and mice, and induces weight gain and inflammation in mice |
publisher |
Cambridge University Press (CUP) |
publishDate |
2012 |
url |
http://dx.doi.org/10.1017/s0007114512003364 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114512003364 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
British Journal of Nutrition volume 109, issue 8, page 1508-1517 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0007114512003364 |
container_title |
British Journal of Nutrition |
container_volume |
109 |
container_issue |
8 |
container_start_page |
1508 |
op_container_end_page |
1517 |
_version_ |
1810432023599251456 |