Toxic effects of dietary hydrolysed lipids: anin vivostudy on fish larvae
We have previously described that fish larvae absorb a larger fraction of dietary monoacylglycerol than TAG. To investigate how dietary hydrolysed lipids affect a vertebrate at early life stages over time, we fed Atlantic cod ( Gadus morhua ) larvae six diets with different degrees of hydrolysed lip...
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Online Access: | http://dx.doi.org/10.1017/s000711451200284x https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S000711451200284X |
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crcambridgeupr:10.1017/s000711451200284x 2024-05-19T07:37:06+00:00 Toxic effects of dietary hydrolysed lipids: anin vivostudy on fish larvae Sæle, Øystein Nordgreen, Andreas Olsvik, Pål A. Hjelle, Jan I. Harboe, Torstein Hamre, Kristin 2012 http://dx.doi.org/10.1017/s000711451200284x https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S000711451200284X en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 109, issue 6, page 1071-1081 ISSN 0007-1145 1475-2662 journal-article 2012 crcambridgeupr https://doi.org/10.1017/s000711451200284x 2024-05-02T06:50:53Z We have previously described that fish larvae absorb a larger fraction of dietary monoacylglycerol than TAG. To investigate how dietary hydrolysed lipids affect a vertebrate at early life stages over time, we fed Atlantic cod ( Gadus morhua ) larvae six diets with different degrees of hydrolysed lipids for 30 d. The different diets had no effect on growth, but there was a positive correlation between the level of hydrolysed lipids in the diets and mortality. Important genes in lipid metabolism, such as PPAR , farnesoid X receptor ( FXR ) and stearoyl-CoA desaturase ( SCD ), were regulated by the different diets. Genes involved in the oxidative stress response did not respond to the increased lipid hydrolysation in the diets. However, enterocyte damage was observed in animals fed diets with 2·7 % NEFA (diet 3) or more. It is thus possible that mortality was due to infections and/or osmotic stress due to the exposure of the subepithelial tissue. In contrast to earlier experiments showing a positive effect of dietary hydrolysed lipids, we have demonstrated a toxic effect of dietary NEFA on Atlantic cod larvae. Toxicity is not acute but needs time to accumulate. Article in Journal/Newspaper atlantic cod Gadus morhua Cambridge University Press British Journal of Nutrition 109 6 1071 1081 |
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Open Polar |
collection |
Cambridge University Press |
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crcambridgeupr |
language |
English |
description |
We have previously described that fish larvae absorb a larger fraction of dietary monoacylglycerol than TAG. To investigate how dietary hydrolysed lipids affect a vertebrate at early life stages over time, we fed Atlantic cod ( Gadus morhua ) larvae six diets with different degrees of hydrolysed lipids for 30 d. The different diets had no effect on growth, but there was a positive correlation between the level of hydrolysed lipids in the diets and mortality. Important genes in lipid metabolism, such as PPAR , farnesoid X receptor ( FXR ) and stearoyl-CoA desaturase ( SCD ), were regulated by the different diets. Genes involved in the oxidative stress response did not respond to the increased lipid hydrolysation in the diets. However, enterocyte damage was observed in animals fed diets with 2·7 % NEFA (diet 3) or more. It is thus possible that mortality was due to infections and/or osmotic stress due to the exposure of the subepithelial tissue. In contrast to earlier experiments showing a positive effect of dietary hydrolysed lipids, we have demonstrated a toxic effect of dietary NEFA on Atlantic cod larvae. Toxicity is not acute but needs time to accumulate. |
format |
Article in Journal/Newspaper |
author |
Sæle, Øystein Nordgreen, Andreas Olsvik, Pål A. Hjelle, Jan I. Harboe, Torstein Hamre, Kristin |
spellingShingle |
Sæle, Øystein Nordgreen, Andreas Olsvik, Pål A. Hjelle, Jan I. Harboe, Torstein Hamre, Kristin Toxic effects of dietary hydrolysed lipids: anin vivostudy on fish larvae |
author_facet |
Sæle, Øystein Nordgreen, Andreas Olsvik, Pål A. Hjelle, Jan I. Harboe, Torstein Hamre, Kristin |
author_sort |
Sæle, Øystein |
title |
Toxic effects of dietary hydrolysed lipids: anin vivostudy on fish larvae |
title_short |
Toxic effects of dietary hydrolysed lipids: anin vivostudy on fish larvae |
title_full |
Toxic effects of dietary hydrolysed lipids: anin vivostudy on fish larvae |
title_fullStr |
Toxic effects of dietary hydrolysed lipids: anin vivostudy on fish larvae |
title_full_unstemmed |
Toxic effects of dietary hydrolysed lipids: anin vivostudy on fish larvae |
title_sort |
toxic effects of dietary hydrolysed lipids: anin vivostudy on fish larvae |
publisher |
Cambridge University Press (CUP) |
publishDate |
2012 |
url |
http://dx.doi.org/10.1017/s000711451200284x https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S000711451200284X |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
British Journal of Nutrition volume 109, issue 6, page 1071-1081 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s000711451200284x |
container_title |
British Journal of Nutrition |
container_volume |
109 |
container_issue |
6 |
container_start_page |
1071 |
op_container_end_page |
1081 |
_version_ |
1799476335412772864 |