Gene–diet interactions on plasma lipid levels in the Inuit population
The Inuit population is often described as being protected against CVD due to their traditional dietary patterns and their unique genetic background. The objective of the present study was to examine gene–diet interaction effects on plasma lipid levels in the Inuit population. Data from the Qanuippi...
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crcambridgeupr:10.1017/s0007114512002231 2024-09-15T18:14:58+00:00 Gene–diet interactions on plasma lipid levels in the Inuit population Rudkowska, Iwona Dewailly, Eric Hegele, Robert A. Boiteau, Véronique Dubé-Linteau, Ariane Abdous, Belkacem Giguere, Yves Chateau-Degat, Marie-Ludivine Vohl, Marie-Claude 2012 http://dx.doi.org/10.1017/s0007114512002231 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114512002231 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 109, issue 5, page 953-961 ISSN 0007-1145 1475-2662 journal-article 2012 crcambridgeupr https://doi.org/10.1017/s0007114512002231 2024-07-10T04:03:23Z The Inuit population is often described as being protected against CVD due to their traditional dietary patterns and their unique genetic background. The objective of the present study was to examine gene–diet interaction effects on plasma lipid levels in the Inuit population. Data from the Qanuippitaa Nunavik Health Survey ( n 553) were analysed via regression models which included the following: genotypes for thirty-five known polymorphisms (SNP) from twenty genes related to lipid metabolism; dietary fat intake including total fat (TotFat) and saturated fat (SatFat) estimated from a FFQ; plasma lipid levels, namely total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and TAG. The results demonstrate that allele frequencies were different in the Inuit population compared with the Caucasian population. Further, seven SNP ( APOA1 − 75G/A (rs670), APOB XbAI (rs693), AGT M235T (rs699), LIPC 480C/T (rs1800588), APOA1 84T/C (rs5070), PPARG2 − 618C/G (rs10865710) and APOE 219G/T (rs405509)) in interaction with TotFat and SatFat were significantly associated with one or two plasma lipid parameters. Another four SNP ( APOC3 3238C>G (rs5128), CETP I405V (rs5882), CYP1A1 A4889G (rs1048943) and ABCA1 Arg219Lys (rs2230806)) in interaction with either TotFat or SatFat intake were significantly associated with one plasma lipid variable. Further, an additive effect of these SNP in interaction with TotFat or SatFat intake was significantly associated with higher TC, LDL-C or TAG levels, as well as with lower HDL-C levels. In conclusion, the present study supports the notion that gene–diet interactions play an important role in modifying plasma lipid levels in the Inuit population. Article in Journal/Newspaper inuit Nunavik Cambridge University Press British Journal of Nutrition 109 5 953 961 |
institution |
Open Polar |
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Cambridge University Press |
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crcambridgeupr |
language |
English |
description |
The Inuit population is often described as being protected against CVD due to their traditional dietary patterns and their unique genetic background. The objective of the present study was to examine gene–diet interaction effects on plasma lipid levels in the Inuit population. Data from the Qanuippitaa Nunavik Health Survey ( n 553) were analysed via regression models which included the following: genotypes for thirty-five known polymorphisms (SNP) from twenty genes related to lipid metabolism; dietary fat intake including total fat (TotFat) and saturated fat (SatFat) estimated from a FFQ; plasma lipid levels, namely total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and TAG. The results demonstrate that allele frequencies were different in the Inuit population compared with the Caucasian population. Further, seven SNP ( APOA1 − 75G/A (rs670), APOB XbAI (rs693), AGT M235T (rs699), LIPC 480C/T (rs1800588), APOA1 84T/C (rs5070), PPARG2 − 618C/G (rs10865710) and APOE 219G/T (rs405509)) in interaction with TotFat and SatFat were significantly associated with one or two plasma lipid parameters. Another four SNP ( APOC3 3238C>G (rs5128), CETP I405V (rs5882), CYP1A1 A4889G (rs1048943) and ABCA1 Arg219Lys (rs2230806)) in interaction with either TotFat or SatFat intake were significantly associated with one plasma lipid variable. Further, an additive effect of these SNP in interaction with TotFat or SatFat intake was significantly associated with higher TC, LDL-C or TAG levels, as well as with lower HDL-C levels. In conclusion, the present study supports the notion that gene–diet interactions play an important role in modifying plasma lipid levels in the Inuit population. |
format |
Article in Journal/Newspaper |
author |
Rudkowska, Iwona Dewailly, Eric Hegele, Robert A. Boiteau, Véronique Dubé-Linteau, Ariane Abdous, Belkacem Giguere, Yves Chateau-Degat, Marie-Ludivine Vohl, Marie-Claude |
spellingShingle |
Rudkowska, Iwona Dewailly, Eric Hegele, Robert A. Boiteau, Véronique Dubé-Linteau, Ariane Abdous, Belkacem Giguere, Yves Chateau-Degat, Marie-Ludivine Vohl, Marie-Claude Gene–diet interactions on plasma lipid levels in the Inuit population |
author_facet |
Rudkowska, Iwona Dewailly, Eric Hegele, Robert A. Boiteau, Véronique Dubé-Linteau, Ariane Abdous, Belkacem Giguere, Yves Chateau-Degat, Marie-Ludivine Vohl, Marie-Claude |
author_sort |
Rudkowska, Iwona |
title |
Gene–diet interactions on plasma lipid levels in the Inuit population |
title_short |
Gene–diet interactions on plasma lipid levels in the Inuit population |
title_full |
Gene–diet interactions on plasma lipid levels in the Inuit population |
title_fullStr |
Gene–diet interactions on plasma lipid levels in the Inuit population |
title_full_unstemmed |
Gene–diet interactions on plasma lipid levels in the Inuit population |
title_sort |
gene–diet interactions on plasma lipid levels in the inuit population |
publisher |
Cambridge University Press (CUP) |
publishDate |
2012 |
url |
http://dx.doi.org/10.1017/s0007114512002231 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114512002231 |
genre |
inuit Nunavik |
genre_facet |
inuit Nunavik |
op_source |
British Journal of Nutrition volume 109, issue 5, page 953-961 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0007114512002231 |
container_title |
British Journal of Nutrition |
container_volume |
109 |
container_issue |
5 |
container_start_page |
953 |
op_container_end_page |
961 |
_version_ |
1810452736149291008 |