Association between trans -fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age
Dietary exposure to trans -fatty acids (TFA) is likely to be high among Canadian Inuit; yet no data are available on the physiological effects of TFA in this population. The purpose of the present study was to assess the association between TFA and plasma lipid profiles in Inuit men and women living...
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Cambridge University Press (CUP)
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Online Access: | http://dx.doi.org/10.1017/s0007114509297182 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114509297182 |
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crcambridgeupr:10.1017/s0007114509297182 2024-03-03T08:45:51+00:00 Association between trans -fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age Counil, Emilie Julien, Pierre Lamarche, Benoit Château-Degat, Marie-Ludivine Ferland, Annie Dewailly, Eric 2009 http://dx.doi.org/10.1017/s0007114509297182 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114509297182 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 102, issue 5, page 766-776 ISSN 0007-1145 1475-2662 Nutrition and Dietetics Medicine (miscellaneous) journal-article 2009 crcambridgeupr https://doi.org/10.1017/s0007114509297182 2024-02-08T08:27:24Z Dietary exposure to trans -fatty acids (TFA) is likely to be high among Canadian Inuit; yet no data are available on the physiological effects of TFA in this population. The purpose of the present study was to assess the association between TFA and plasma lipid profiles in Inuit men and women living in Nunavik (Québec, Canada). In a cross-sectional, population-based survey, a total of 795 Nunavik Inuit eligible participants gave a blood sample. Exposure to TFA was assessed by their relative proportion in erythrocyte membrane. We performed multiple regression analysis using plasma lipids or their linear combinations as the dependent variables and TFA as the main predictor, adjusting for potential confounders. The associations varied markedly between the sexes and according to age. In men ( n 357, aged 36·3 ( sd 14·3) years, TFA 1·24 ( sd 0·54) %), TFA tended to be negatively associated with HDL-cholesterol (HDL-C), apoA1 and LDL particle size, and positively associated with non-HDL-C, LDL-cholesterol (LDL-C), apoB100, the apoB100:apoA1 ratio and the ratios of total cholesterol (TC), LDL-C and TAG to HDL-C. No such trends were observed in women ( n 438, aged 37·0 ( sd 14·1) years, TFA 1·16 ( sd 0·54) %), except for HDL-C and apoA1 in women aged 50 years and more. These results suggest that TFA could raise the risk of CHD in Inuit men at least through their physiological effects on plasma lipids. The differential associations reported in pre- and postmenopausal women need to be reproduced in other populations and in experimental studies addressing the influence of sex hormones in response to dietary fats. Article in Journal/Newspaper inuit Nunavik Cambridge University Press Canada Nunavik British Journal of Nutrition 102 5 766 776 |
institution |
Open Polar |
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Cambridge University Press |
op_collection_id |
crcambridgeupr |
language |
English |
topic |
Nutrition and Dietetics Medicine (miscellaneous) |
spellingShingle |
Nutrition and Dietetics Medicine (miscellaneous) Counil, Emilie Julien, Pierre Lamarche, Benoit Château-Degat, Marie-Ludivine Ferland, Annie Dewailly, Eric Association between trans -fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
topic_facet |
Nutrition and Dietetics Medicine (miscellaneous) |
description |
Dietary exposure to trans -fatty acids (TFA) is likely to be high among Canadian Inuit; yet no data are available on the physiological effects of TFA in this population. The purpose of the present study was to assess the association between TFA and plasma lipid profiles in Inuit men and women living in Nunavik (Québec, Canada). In a cross-sectional, population-based survey, a total of 795 Nunavik Inuit eligible participants gave a blood sample. Exposure to TFA was assessed by their relative proportion in erythrocyte membrane. We performed multiple regression analysis using plasma lipids or their linear combinations as the dependent variables and TFA as the main predictor, adjusting for potential confounders. The associations varied markedly between the sexes and according to age. In men ( n 357, aged 36·3 ( sd 14·3) years, TFA 1·24 ( sd 0·54) %), TFA tended to be negatively associated with HDL-cholesterol (HDL-C), apoA1 and LDL particle size, and positively associated with non-HDL-C, LDL-cholesterol (LDL-C), apoB100, the apoB100:apoA1 ratio and the ratios of total cholesterol (TC), LDL-C and TAG to HDL-C. No such trends were observed in women ( n 438, aged 37·0 ( sd 14·1) years, TFA 1·16 ( sd 0·54) %), except for HDL-C and apoA1 in women aged 50 years and more. These results suggest that TFA could raise the risk of CHD in Inuit men at least through their physiological effects on plasma lipids. The differential associations reported in pre- and postmenopausal women need to be reproduced in other populations and in experimental studies addressing the influence of sex hormones in response to dietary fats. |
format |
Article in Journal/Newspaper |
author |
Counil, Emilie Julien, Pierre Lamarche, Benoit Château-Degat, Marie-Ludivine Ferland, Annie Dewailly, Eric |
author_facet |
Counil, Emilie Julien, Pierre Lamarche, Benoit Château-Degat, Marie-Ludivine Ferland, Annie Dewailly, Eric |
author_sort |
Counil, Emilie |
title |
Association between trans -fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_short |
Association between trans -fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_full |
Association between trans -fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_fullStr |
Association between trans -fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_full_unstemmed |
Association between trans -fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_sort |
association between trans -fatty acids in erythrocytes and pro-atherogenic lipid profiles among canadian inuit of nunavik: possible influences of sex and age |
publisher |
Cambridge University Press (CUP) |
publishDate |
2009 |
url |
http://dx.doi.org/10.1017/s0007114509297182 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114509297182 |
geographic |
Canada Nunavik |
geographic_facet |
Canada Nunavik |
genre |
inuit Nunavik |
genre_facet |
inuit Nunavik |
op_source |
British Journal of Nutrition volume 102, issue 5, page 766-776 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0007114509297182 |
container_title |
British Journal of Nutrition |
container_volume |
102 |
container_issue |
5 |
container_start_page |
766 |
op_container_end_page |
776 |
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1792501508032430080 |