Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease
Trehalose is a disaccharide, the main dietary source being mushrooms. It has been approved as an additive in the preparation of dried food. Isolated intestinal trehalase deficiency is found in 8 % of Greenlanders, but is rare elsewhere. The normal range of trehalase activity and the incidence of iso...
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Language: | English |
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Cambridge University Press (CUP)
2000
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Online Access: | http://dx.doi.org/10.1017/s0007114500000313 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114500000313 |
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crcambridgeupr:10.1017/s0007114500000313 2024-06-23T07:53:26+00:00 Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease Murray, Iain A. Coupland, Kathryn Smith, Julie A. Ansell, I. David Long, Richard G. 2000 http://dx.doi.org/10.1017/s0007114500000313 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114500000313 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms British Journal of Nutrition volume 83, issue 3, page 241-245 ISSN 0007-1145 1475-2662 journal-article 2000 crcambridgeupr https://doi.org/10.1017/s0007114500000313 2024-06-05T04:04:09Z Trehalose is a disaccharide, the main dietary source being mushrooms. It has been approved as an additive in the preparation of dried food. Isolated intestinal trehalase deficiency is found in 8 % of Greenlanders, but is rare elsewhere. The normal range of trehalase activity and the incidence of isolated trehalase deficiency in the UK have not been reported. Patients ( n 400) were investigated for suspected malabsorption. Endoscopic distal duodenal biopsies were taken for histological assessment and maltase, sucrase, lactase and trehalase estimation. Disaccharidase activities were determined by Dahlqvist's technique (). Most patients ( n 369) had normal duodenal histology. In these, square root transformation of trehalase activity produced a normal distribution. The normal range (mean ± 2 SD) was 4·79–37·12 U/g protein. One patient had an isolated borderline trehalase deficiency. The thirty-one patients with villous atrophy had significantly reduced disaccharidase activities. With ingestion of a gluten-free diet, maltase, sucrase and trehalase activities recovered to normal in most patients, whereas lactase activity did not. The normal range and very low incidence of isolated enzyme deficiency is comparable with that described in populations from the USA and mainland Europe. Activity is significantly reduced in untreated coeliac disease and recovers with treatment with a gluten-free diet. There is no place for routine determination of trehalase activity in the UK population and there should be no concern over the introduction of trehalose-containing dried foods. Article in Journal/Newspaper greenlander* Cambridge University Press British Journal of Nutrition 83 3 241 245 |
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Open Polar |
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Cambridge University Press |
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crcambridgeupr |
language |
English |
description |
Trehalose is a disaccharide, the main dietary source being mushrooms. It has been approved as an additive in the preparation of dried food. Isolated intestinal trehalase deficiency is found in 8 % of Greenlanders, but is rare elsewhere. The normal range of trehalase activity and the incidence of isolated trehalase deficiency in the UK have not been reported. Patients ( n 400) were investigated for suspected malabsorption. Endoscopic distal duodenal biopsies were taken for histological assessment and maltase, sucrase, lactase and trehalase estimation. Disaccharidase activities were determined by Dahlqvist's technique (). Most patients ( n 369) had normal duodenal histology. In these, square root transformation of trehalase activity produced a normal distribution. The normal range (mean ± 2 SD) was 4·79–37·12 U/g protein. One patient had an isolated borderline trehalase deficiency. The thirty-one patients with villous atrophy had significantly reduced disaccharidase activities. With ingestion of a gluten-free diet, maltase, sucrase and trehalase activities recovered to normal in most patients, whereas lactase activity did not. The normal range and very low incidence of isolated enzyme deficiency is comparable with that described in populations from the USA and mainland Europe. Activity is significantly reduced in untreated coeliac disease and recovers with treatment with a gluten-free diet. There is no place for routine determination of trehalase activity in the UK population and there should be no concern over the introduction of trehalose-containing dried foods. |
format |
Article in Journal/Newspaper |
author |
Murray, Iain A. Coupland, Kathryn Smith, Julie A. Ansell, I. David Long, Richard G. |
spellingShingle |
Murray, Iain A. Coupland, Kathryn Smith, Julie A. Ansell, I. David Long, Richard G. Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease |
author_facet |
Murray, Iain A. Coupland, Kathryn Smith, Julie A. Ansell, I. David Long, Richard G. |
author_sort |
Murray, Iain A. |
title |
Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease |
title_short |
Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease |
title_full |
Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease |
title_fullStr |
Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease |
title_full_unstemmed |
Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease |
title_sort |
intestinal trehalase activity in a uk population: establishing a normal range and the effect of disease |
publisher |
Cambridge University Press (CUP) |
publishDate |
2000 |
url |
http://dx.doi.org/10.1017/s0007114500000313 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114500000313 |
genre |
greenlander* |
genre_facet |
greenlander* |
op_source |
British Journal of Nutrition volume 83, issue 3, page 241-245 ISSN 0007-1145 1475-2662 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1017/s0007114500000313 |
container_title |
British Journal of Nutrition |
container_volume |
83 |
container_issue |
3 |
container_start_page |
241 |
op_container_end_page |
245 |
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1802645061202083840 |