Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial
Abstract The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these conditions. Several studies have shown a protein preload before a me...
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crcambridgeupr:10.1017/jns.2018.23 2024-10-13T14:05:57+00:00 Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial Dale, Hanna Fjeldheim Jensen, Caroline Hausken, Trygve Lied, Einar Hatlebakk, Jan Gunnar Brønstad, Ingeborg Lihaug Hoff, Dag Arne Lied, Gülen Arslan 2018 http://dx.doi.org/10.1017/jns.2018.23 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S204867901800023X en eng Cambridge University Press (CUP) http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ Journal of Nutritional Science volume 7 ISSN 2048-6790 journal-article 2018 crcambridgeupr https://doi.org/10.1017/jns.2018.23 2024-10-02T04:01:16Z Abstract The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these conditions. Several studies have shown a protein preload before a meal to be effective in lowering the postprandial glycaemic response in healthy individuals and patients with T2DM. The aim of the present study was to assess the effect of a marine protein hydrolysate (MPH) from Atlantic cod ( Gadus morhua ) on postprandial glucose metabolism in healthy, middle-aged to elderly subjects. This double-blind cross-over trial ( n 41) included two study days with 4–7 d wash-out in between. The intervention consisted of 20 mg of MPH (or casein as control) per kg body weight given before a breakfast meal. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose, insulin and plasma glucagon-like peptide 1 (GLP-1) in 20 min intervals for 180 min. In a mixed-model regression analysis, no differences were observed between MPH and control for postprandial glucose concentration (mean difference: −0·04 (95 % CI –0·17, 0·09) mmol/l; P = 0·573) or GLP-1 concentration (mean difference between geometric means: 1·02 (95 % CI 0·99, 1·06) pmol/l; P = 0·250). The postprandial insulin concentration was significantly lower after MPH compared with control (mean difference between geometric means: 1·067 (95 % CI 1·01, 1·13) mIU/l; P = 0·032). Our findings demonstrate that a single dose of MPH before a breakfast meal reduces postprandial insulin secretion, without affecting blood glucose response or GLP-1 levels, in healthy individuals. Further studies with repeated dosing and in target groups with abnormal glucose control are warranted. Article in Journal/Newspaper atlantic cod Gadus morhua Cambridge University Press Journal of Nutritional Science 7 |
institution |
Open Polar |
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Cambridge University Press |
op_collection_id |
crcambridgeupr |
language |
English |
description |
Abstract The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these conditions. Several studies have shown a protein preload before a meal to be effective in lowering the postprandial glycaemic response in healthy individuals and patients with T2DM. The aim of the present study was to assess the effect of a marine protein hydrolysate (MPH) from Atlantic cod ( Gadus morhua ) on postprandial glucose metabolism in healthy, middle-aged to elderly subjects. This double-blind cross-over trial ( n 41) included two study days with 4–7 d wash-out in between. The intervention consisted of 20 mg of MPH (or casein as control) per kg body weight given before a breakfast meal. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose, insulin and plasma glucagon-like peptide 1 (GLP-1) in 20 min intervals for 180 min. In a mixed-model regression analysis, no differences were observed between MPH and control for postprandial glucose concentration (mean difference: −0·04 (95 % CI –0·17, 0·09) mmol/l; P = 0·573) or GLP-1 concentration (mean difference between geometric means: 1·02 (95 % CI 0·99, 1·06) pmol/l; P = 0·250). The postprandial insulin concentration was significantly lower after MPH compared with control (mean difference between geometric means: 1·067 (95 % CI 1·01, 1·13) mIU/l; P = 0·032). Our findings demonstrate that a single dose of MPH before a breakfast meal reduces postprandial insulin secretion, without affecting blood glucose response or GLP-1 levels, in healthy individuals. Further studies with repeated dosing and in target groups with abnormal glucose control are warranted. |
format |
Article in Journal/Newspaper |
author |
Dale, Hanna Fjeldheim Jensen, Caroline Hausken, Trygve Lied, Einar Hatlebakk, Jan Gunnar Brønstad, Ingeborg Lihaug Hoff, Dag Arne Lied, Gülen Arslan |
spellingShingle |
Dale, Hanna Fjeldheim Jensen, Caroline Hausken, Trygve Lied, Einar Hatlebakk, Jan Gunnar Brønstad, Ingeborg Lihaug Hoff, Dag Arne Lied, Gülen Arslan Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
author_facet |
Dale, Hanna Fjeldheim Jensen, Caroline Hausken, Trygve Lied, Einar Hatlebakk, Jan Gunnar Brønstad, Ingeborg Lihaug Hoff, Dag Arne Lied, Gülen Arslan |
author_sort |
Dale, Hanna Fjeldheim |
title |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_short |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_full |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_fullStr |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_full_unstemmed |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_sort |
effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
publisher |
Cambridge University Press (CUP) |
publishDate |
2018 |
url |
http://dx.doi.org/10.1017/jns.2018.23 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S204867901800023X |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
Journal of Nutritional Science volume 7 ISSN 2048-6790 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1017/jns.2018.23 |
container_title |
Journal of Nutritional Science |
container_volume |
7 |
_version_ |
1812811984086761472 |