Characteristics of Subjects With Schizophrenia Spectrum Disorder With and Without Antipsychotic Medication – a 10-Year Follow-Up of the Northern Finland 1966 Birth Cohort Study
Abstract Objective To estimate the prevalence of non-medicated subjects having schizophrenia spectrum disorder and to study how they differ from medicated subjects in terms of sociodemographic and illness-related variables. We also aim to find the predictors for successful antipsychotic withdrawal....
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Cambridge University Press (CUP)
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crcambridgeupr:10.1016/j.eurpsy.2011.06.009 2024-09-09T19:59:14+00:00 Characteristics of Subjects With Schizophrenia Spectrum Disorder With and Without Antipsychotic Medication – a 10-Year Follow-Up of the Northern Finland 1966 Birth Cohort Study Moilanen, J. Haapea, M. Miettunen, J. Jääskeläinen, E. Veijola, J. Isohanni, M. Koponen, H. 2011 http://dx.doi.org/10.1016/j.eurpsy.2011.06.009 https://api.elsevier.com/content/article/PII:S0924933811001143?httpAccept=text/xml https://api.elsevier.com/content/article/PII:S0924933811001143?httpAccept=text/plain https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0924933800192570 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms European Psychiatry volume 28, issue 1, page 53-58 ISSN 0924-9338 1778-3585 journal-article 2011 crcambridgeupr https://doi.org/10.1016/j.eurpsy.2011.06.009 2024-07-31T04:02:11Z Abstract Objective To estimate the prevalence of non-medicated subjects having schizophrenia spectrum disorder and to study how they differ from medicated subjects in terms of sociodemographic and illness-related variables. We also aim to find the predictors for successful antipsychotic withdrawal. Methods Data of 70 subjects with schizophrenic psychoses (mean duration of illness 10.4 years) from the Northern Finland 1966 Birth Cohort were gathered by interview at the age of 34 and from hospital records. The stability of remission was assessed by comparing hospitalization rates between non-medicated and medicated subjects over an 8.7-year additional follow-up period. Results Twenty-four (34%) subjects were currently not receiving medication. They were more often males, less often on a disability pension, more often in remission, and had better clinical outcomes. Relapses during the follow-up were equally frequent between non-medicated and medicated subjects (47% vs. 56%). Not having been hospitalised during previous 5 years before the interview predicted long-term successful antipsychotic withdrawal without relapse. Conclusions Despite a lack of precise predictors, there might be subgroup of schizophrenia spectrum subjects who do not need permanent antipsychotic medication, and a fewer previous psychiatric treatments may indicate such a subgroup. Article in Journal/Newspaper Northern Finland Cambridge University Press European Psychiatry 28 1 53 58 |
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description |
Abstract Objective To estimate the prevalence of non-medicated subjects having schizophrenia spectrum disorder and to study how they differ from medicated subjects in terms of sociodemographic and illness-related variables. We also aim to find the predictors for successful antipsychotic withdrawal. Methods Data of 70 subjects with schizophrenic psychoses (mean duration of illness 10.4 years) from the Northern Finland 1966 Birth Cohort were gathered by interview at the age of 34 and from hospital records. The stability of remission was assessed by comparing hospitalization rates between non-medicated and medicated subjects over an 8.7-year additional follow-up period. Results Twenty-four (34%) subjects were currently not receiving medication. They were more often males, less often on a disability pension, more often in remission, and had better clinical outcomes. Relapses during the follow-up were equally frequent between non-medicated and medicated subjects (47% vs. 56%). Not having been hospitalised during previous 5 years before the interview predicted long-term successful antipsychotic withdrawal without relapse. Conclusions Despite a lack of precise predictors, there might be subgroup of schizophrenia spectrum subjects who do not need permanent antipsychotic medication, and a fewer previous psychiatric treatments may indicate such a subgroup. |
format |
Article in Journal/Newspaper |
author |
Moilanen, J. Haapea, M. Miettunen, J. Jääskeläinen, E. Veijola, J. Isohanni, M. Koponen, H. |
spellingShingle |
Moilanen, J. Haapea, M. Miettunen, J. Jääskeläinen, E. Veijola, J. Isohanni, M. Koponen, H. Characteristics of Subjects With Schizophrenia Spectrum Disorder With and Without Antipsychotic Medication – a 10-Year Follow-Up of the Northern Finland 1966 Birth Cohort Study |
author_facet |
Moilanen, J. Haapea, M. Miettunen, J. Jääskeläinen, E. Veijola, J. Isohanni, M. Koponen, H. |
author_sort |
Moilanen, J. |
title |
Characteristics of Subjects With Schizophrenia Spectrum Disorder With and Without Antipsychotic Medication – a 10-Year Follow-Up of the Northern Finland 1966 Birth Cohort Study |
title_short |
Characteristics of Subjects With Schizophrenia Spectrum Disorder With and Without Antipsychotic Medication – a 10-Year Follow-Up of the Northern Finland 1966 Birth Cohort Study |
title_full |
Characteristics of Subjects With Schizophrenia Spectrum Disorder With and Without Antipsychotic Medication – a 10-Year Follow-Up of the Northern Finland 1966 Birth Cohort Study |
title_fullStr |
Characteristics of Subjects With Schizophrenia Spectrum Disorder With and Without Antipsychotic Medication – a 10-Year Follow-Up of the Northern Finland 1966 Birth Cohort Study |
title_full_unstemmed |
Characteristics of Subjects With Schizophrenia Spectrum Disorder With and Without Antipsychotic Medication – a 10-Year Follow-Up of the Northern Finland 1966 Birth Cohort Study |
title_sort |
characteristics of subjects with schizophrenia spectrum disorder with and without antipsychotic medication – a 10-year follow-up of the northern finland 1966 birth cohort study |
publisher |
Cambridge University Press (CUP) |
publishDate |
2011 |
url |
http://dx.doi.org/10.1016/j.eurpsy.2011.06.009 https://api.elsevier.com/content/article/PII:S0924933811001143?httpAccept=text/xml https://api.elsevier.com/content/article/PII:S0924933811001143?httpAccept=text/plain https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0924933800192570 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
European Psychiatry volume 28, issue 1, page 53-58 ISSN 0924-9338 1778-3585 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1016/j.eurpsy.2011.06.009 |
container_title |
European Psychiatry |
container_volume |
28 |
container_issue |
1 |
container_start_page |
53 |
op_container_end_page |
58 |
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1809930390491627520 |