Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients
Abstract Objective The Temperament and Character Inventory (TCI) is commonly used in adult populations. Our aim was to explore: (1) if there are specific differences in temperament dimensions related to depression in comparison with general population, (2) if the treatment response during the acute...
Published in: | European Psychiatry |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Cambridge University Press (CUP)
2012
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1016/j.eurpsy.2010.07.006 https://api.elsevier.com/content/article/PII:S0924933810001501?httpAccept=text/xml https://api.elsevier.com/content/article/PII:S0924933810001501?httpAccept=text/plain https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0924933800258173 |
id |
crcambridgeupr:10.1016/j.eurpsy.2010.07.006 |
---|---|
record_format |
openpolar |
spelling |
crcambridgeupr:10.1016/j.eurpsy.2010.07.006 2024-06-09T07:48:32+00:00 Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients Kampman, O. Poutanen, O. Illi, A. Setälä-Soikkeli, E. Viikki, M. Nuolivirta, T. Leinonen, E. 2012 http://dx.doi.org/10.1016/j.eurpsy.2010.07.006 https://api.elsevier.com/content/article/PII:S0924933810001501?httpAccept=text/xml https://api.elsevier.com/content/article/PII:S0924933810001501?httpAccept=text/plain https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0924933800258173 en eng Cambridge University Press (CUP) https://www.cambridge.org/core/terms European Psychiatry volume 27, issue 4, page 245-249 ISSN 0924-9338 1778-3585 journal-article 2012 crcambridgeupr https://doi.org/10.1016/j.eurpsy.2010.07.006 2024-05-15T13:02:47Z Abstract Objective The Temperament and Character Inventory (TCI) is commonly used in adult populations. Our aim was to explore: (1) if there are specific differences in temperament dimensions related to depression in comparison with general population, (2) if the treatment response during the acute phase of major depressive disorder (MDD) is predictable by TCI temperament dimensions. Method Temperament profiles in 98 MDD patients were compared with a Finnish community sample. The patients were treated with serotonin selective reuptake inhibitors (SSRIs) for 6weeks and their temperament profiles were assessed at baseline and endpoint. The harm avoidance (HA) and depression scores at baseline and endpoint were modelled with path analysis. For path modelling, we tested the relationships between different temperament dimensions and depression symptoms and other clinical variables with Mancova model. Results The HA scores were significantly higher in patients both at baseline and endpoint compared to the Northern Finland 1966 Birth Cohort (NFBC). The patients, and especially males, had slightly higher reward dependency (RD) scores. HA at endpoint explained moderately the Montgomery Åsberg Depression Rating Scale (MADRS) endpoint score. HA endpoint score was strongly explained by HA baseline score. Conclusions HA is associated with risk of and treatment response to depression. Article in Journal/Newspaper Northern Finland Cambridge University Press Åsberg ENVELOPE(12.101,12.101,65.484,65.484) European Psychiatry 27 4 245 249 |
institution |
Open Polar |
collection |
Cambridge University Press |
op_collection_id |
crcambridgeupr |
language |
English |
description |
Abstract Objective The Temperament and Character Inventory (TCI) is commonly used in adult populations. Our aim was to explore: (1) if there are specific differences in temperament dimensions related to depression in comparison with general population, (2) if the treatment response during the acute phase of major depressive disorder (MDD) is predictable by TCI temperament dimensions. Method Temperament profiles in 98 MDD patients were compared with a Finnish community sample. The patients were treated with serotonin selective reuptake inhibitors (SSRIs) for 6weeks and their temperament profiles were assessed at baseline and endpoint. The harm avoidance (HA) and depression scores at baseline and endpoint were modelled with path analysis. For path modelling, we tested the relationships between different temperament dimensions and depression symptoms and other clinical variables with Mancova model. Results The HA scores were significantly higher in patients both at baseline and endpoint compared to the Northern Finland 1966 Birth Cohort (NFBC). The patients, and especially males, had slightly higher reward dependency (RD) scores. HA at endpoint explained moderately the Montgomery Åsberg Depression Rating Scale (MADRS) endpoint score. HA endpoint score was strongly explained by HA baseline score. Conclusions HA is associated with risk of and treatment response to depression. |
format |
Article in Journal/Newspaper |
author |
Kampman, O. Poutanen, O. Illi, A. Setälä-Soikkeli, E. Viikki, M. Nuolivirta, T. Leinonen, E. |
spellingShingle |
Kampman, O. Poutanen, O. Illi, A. Setälä-Soikkeli, E. Viikki, M. Nuolivirta, T. Leinonen, E. Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients |
author_facet |
Kampman, O. Poutanen, O. Illi, A. Setälä-Soikkeli, E. Viikki, M. Nuolivirta, T. Leinonen, E. |
author_sort |
Kampman, O. |
title |
Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients |
title_short |
Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients |
title_full |
Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients |
title_fullStr |
Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients |
title_full_unstemmed |
Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients |
title_sort |
temperament profiles, major depression, and response to treatment with ssris in psychiatric outpatients |
publisher |
Cambridge University Press (CUP) |
publishDate |
2012 |
url |
http://dx.doi.org/10.1016/j.eurpsy.2010.07.006 https://api.elsevier.com/content/article/PII:S0924933810001501?httpAccept=text/xml https://api.elsevier.com/content/article/PII:S0924933810001501?httpAccept=text/plain https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0924933800258173 |
long_lat |
ENVELOPE(12.101,12.101,65.484,65.484) |
geographic |
Åsberg |
geographic_facet |
Åsberg |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
European Psychiatry volume 27, issue 4, page 245-249 ISSN 0924-9338 1778-3585 |
op_rights |
https://www.cambridge.org/core/terms |
op_doi |
https://doi.org/10.1016/j.eurpsy.2010.07.006 |
container_title |
European Psychiatry |
container_volume |
27 |
container_issue |
4 |
container_start_page |
245 |
op_container_end_page |
249 |
_version_ |
1801380297213739008 |